An increase in joy after two weeks is more specific of later antidepressant response than a decrease in sadness

Gorwood, Philip; Demyttenare, K.; Vaïva, Guillaume; Llorca, Pierre Michel; Baylé, Franck; Courtet, Philippe

doi:10.1016/j.jad.2015.06.019

Cited by 12 publications

(6 citation statements)

References 47 publications

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“…more predictive of a good antidepressant outcome than early changes in negative mood. 21,22 The correlations between positive affect, negative affect, hedonic tone, and the independent LAPS variables give some interesting results: the highest correlations with cognitive functioning, overall functioning, meaningful life, and happiness are with positive affect, and these correlations are always higher than with negative affect (between 0.63 and 0.78 versus between -0.42 and -0.66). The highly positive correlation between cognitive functioning and positive affect (R = 0.66) is remarkable.…”

Section: Discussionmentioning

confidence: 99%

Is there enough “interest in and pleasure in” the concept of depression? The development of the Leuven Affect and Pleasure Scale (LAPS)

2017

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This preliminary report suggests that the LAPS offers a comprehensive assessment of negative and positive affect, of hedonic tone, and of independent variables (cognitive functioning, overall functioning, meaningful life, and happiness). Clinically relevant differences in subscores were found in 3 groups of subjects with variable levels of depression (healthy subjects, mildly depressed subjects, and severely depressed inpatients).

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Section: Discussionmentioning

confidence: 99%

Is there enough “interest in and pleasure in” the concept of depression? The development of the Leuven Affect and Pleasure Scale (LAPS)

2017

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“…Structurally redirecting attention to positive (rather than neutral) features and stimulating positive emotions may thus be an efficient antidote for depressive symptoms such as lack of positive emotions, abundance of negative emotions, and negative attentional biases. In line with this argument, several studies suggest that increases in positive emotions are more important in predicting recovery from depression than decreases in negative emotions (Geschwind et al, 2011;Gorwood et al, 2015).…”

Section: A Stronger Focus On Positive Emotions?mentioning

confidence: 87%

Positivity pays off: Clients’ perspectives on positive compared with traditional cognitive behavioral therapy for depression.

Geschwind¹,

Bosgraaf²,

Bannink³

et al. 2020

Psychotherapy

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“…Many markers may serve as predictors of treatment response. For example, a prior study demonstrated that an increase in joy after 2 weeks of treatment is strongly specific for later antidepressant response and remission in MDD (Gorwood et al 2015a ). Gorwood et al found that motivation is the most impaired in depressed patients, responds best to treatment and shows the best predictive value for antidepressant treatment response in the Multidimensional Assessment of Thymic States (MAThyS) rating scales (Gorwood et al 2015b ).…”

Section: Discussionmentioning

confidence: 99%

“…Predicting a prognosis in an early phase of antidepressant treatment may facilitate an effort to find an appropriate drug for individuals with MDD at the earliest opportunity (Nakajima et al 2010 ). Previous studies have demonstrated that early changes in joy, motivation, depressive symptoms, plasma catecholamine metabolites, repeated cortisol awakening response, quantitative electroencephalography biomarkers after a short time of ADM (e.g., 2 weeks) could predict eventual antidepressant treatment outcomes in depressed patients (Beck et al 2015 ; Gorwood et al 2015a , b ; Hunter et al 2010 ; Sakurai et al 2013 ; Ueda et al 2002 ; Vermeiden et al 2015 ). Furthermore, evidence from neuroimaging studies suggests that interhemispheric asynchrony and disrupted network topological configurations could also serve as pretreatment predictors of early antidepressant response in MDD (Hou et al 2016a , b ).…”

Section: Introductionmentioning

confidence: 99%

Variance of the global signal as a pretreatment predictor of antidepressant treatment response in drug-naïve major depressive disorder

Zhu

Cai

Yuan

et al. 2018

Brain Imaging and Behavior

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Several behavioral and neuroimaging markers could be used to predict eventual antidepressant medication (ADM) outcomes in patients with major depressive disorder (MDD). However, these predictors are either subjective or complex, which has limited their clinical use. Thus, we aimed to identify an objective and easy-to-get marker to predict early therapeutic efficacy. Forty-seven drug-naïve patients with MDD and 47 age-, gender- and education-matched healthy controls underwent resting-state functional magnetic resonance imaging (fMRI) scans. We calculated the variable coefficient (VC) of the global signal for each subject. Baseline Hamilton Rating Scale for Depression (HRSD) score and that after 2 weeks of ADM were assessed for patients. Although there was no difference in VC between patients with MDD and healthy controls, we found a significant positive correlation between the VC and the decline rate of HRSD scores in the patients. Compared with the non-responding depression (NRD) group, the treatment-responsive depression (TRD) group had a higher VC. Receiver operator characteristic curve analysis revealed that the VC exhibited a good ability to differentiate TRD from NRD. In addition, the linear and logistic regression analyses showed that the VC was a significant predictor of the decline rate of HRSD scores and the antidepressant treatment response. These findings suggest that variance of the global signal may serve as a useful marker to help clinicians find an appropriate drug for individuals with MDD at the earliest opportunity and then further to facilitate personalized therapy.

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An increase in joy after two weeks is more specific of later antidepressant response than a decrease in sadness

Cited by 12 publications

References 47 publications

Is there enough “interest in and pleasure in” the concept of depression? The development of the Leuven Affect and Pleasure Scale (LAPS)

Is there enough “interest in and pleasure in” the concept of depression? The development of the Leuven Affect and Pleasure Scale (LAPS)

Positivity pays off: Clients’ perspectives on positive compared with traditional cognitive behavioral therapy for depression.

Variance of the global signal as a pretreatment predictor of antidepressant treatment response in drug-naïve major depressive disorder

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