An inclusive study of recent advancements in Alzheimer's disease: A comprehensive review

Singh, Sukanya; Mahajan, Mitali; Kumar, Dhawal; Singh, Kunika; Chowdhary, Mehvish; Amit,

doi:10.1016/j.npep.2023.102369

Cited by 4 publications

(2 citation statements)

References 129 publications

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“…AChE and BuChE are the two most important enzymes responsible for acetylcholine hydrolysis. In a normal brain, BuChE is primarily found in glial cells, but in an AD brain, BuChE activity rises by 40-90%, resulting in a decrease in ACh activity [127]. Rivastigmine is CNS selective and therefore has fewer side effects on the peripheral nervous system.…”

Section: Acetylcholinesterase Inhibitors (Acheis)mentioning

confidence: 99%

“…They found that rats with an oral infection of Porphyromonas gingivalis had worse spatial memory; significantly more alveolar bone loss; significantly higher levels of proinflammatory factors in cerebrospinal fluid, serum, and hippocampus; and more P-Tau staining of the CA1 hippocampal regions. Via q-PCR quantification, they identified the presence of RgpA and Kgp gingipain genes in the rat hippocampus [127,153]. Kantarci et al investigated the status of alveolar bone loss and changes in neuroinflammatory responses in AD model mice and wild-type (WT) mice by placing silk ligatures at the maxillary second molar in mice to cause oral bacterial colonization and induce periodontitis.…”

Section: Study Of the Correlation Between Periodontitis And Admentioning

confidence: 99%

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Advances in the Study of the Pathology and Treatment of Alzheimer’s Disease and Its Association with Periodontitis

Tang,

Sun,

Yang

et al. 2023

Life

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Alzheimer’s disease (AD) has become one of the leading causes of health problems in the elderly, and studying its causes and treatments remains a serious challenge for researchers worldwide. The two main pathological features of Alzheimer’s disease are the extracellular deposition of β-amyloid (Aβ) to form senile plaques and the intracellular aggregation of hyperphosphorylated Tau protein to form neurofibrillary tangles (NFTs). Researchers have proposed several hypotheses to elucidate the pathogenesis of AD, but due to the complexity of the pathophysiologic factors involved in the development of AD, no effective drugs have been found to stop the progression of the disease. Currently, the mainstay drugs used to treat AD can only alleviate the patient’s symptoms and do not have a therapeutic effect. As researchers explore interactions among diseases, much evidence suggests that there is a close link between periodontitis and AD, and that periodontal pathogenic bacteria can exacerbate Aβ deposition and Tau protein hyperphosphorylation through neuroinflammatory mechanisms, thereby advancing the pathogenesis of AD. This article reviews recent advances in the pathogenesis of AD, available therapeutic agents, the relevance of periodontitis to AD, and mechanisms of action.

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Section: Acetylcholinesterase Inhibitors (Acheis)mentioning

confidence: 99%

Section: Study Of the Correlation Between Periodontitis And Admentioning

confidence: 99%

Advances in the Study of the Pathology and Treatment of Alzheimer’s Disease and Its Association with Periodontitis

Tang,

Sun,

Yang

et al. 2023

Life

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Exploring the Impacts of Angelica purpurascens Extracts on Anticholinergic, Antidiabetic, Antibacterial Potential, and Antioxidant Capacity

Topal,

Yılmaz

2024

Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi

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In Kars-Sarıkamış-Soğanlı, Angelica purpurascens (A. purpurascens) emerges as a promising natural antioxidant source. Extracts from its leaves, branches, and flowers underwent thorough bioanalytical assessments. The leaf extract exhibited the highest concentrations of herbal flavonoids (45.22 µg QE/mg extract) and total phenolics (28.96 µg GAE/mg extract). Branch extracts demonstrated significant enzymatic activity against AChE and BChE with IC50 values of 37.26 mg/mL and 9.08 mg/mL respectively. The flower extract displayed notable antibacterial properties. This study sheds light on the therapeutic potential of A. purpurascens ethanol extracts, suggesting benefits for Alzheimer’s, cell damage-induced diseases, and diabetes mellitus. It pioneers new enzymatic and antioxidant insights and contributes to understanding this abundant Türkiye species. A. purpurascens holds promise for pharmaceutical exploration, offering potential solutions for challenging health conditions

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Is Effective Recruitment Strategy Critical to Assess Brain Cognitive Function of Super Agers in Rural West Texas

Brownell,

Sehar,

Kshirsagar

et al. 2024

ADR

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Our commentary aims to elucidate the importance of participant recruitment strategy in healthy brain aging study, particularly in rural West Texas, where more than 50% of the population are Hispanics and Latinos. The objective of our health aging study is to investigate the possible influence of biological, sociodemographic, and lifestyle factors on the occurrence of chronic diseases and dementia in the aging populations of West Texas. The success of this initiative is, in large part, reliant on high-quality, effective recruitment of participants. To that end, we propose an increase in our strategic recruitment efforts for both healthy, cognitively superior agers as well as those with mild cognitive impairment and patients with Alzheimer’s disease in rural west Texas. We discussed, multi-advertising approaches, including ads in the local newspapers, local TV Channels and poster boards in senior centers.

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An inclusive study of recent advancements in Alzheimer's disease: A comprehensive review

Cited by 4 publications

References 129 publications

Advances in the Study of the Pathology and Treatment of Alzheimer’s Disease and Its Association with Periodontitis

Advances in the Study of the Pathology and Treatment of Alzheimer’s Disease and Its Association with Periodontitis

Exploring the Impacts of Angelica purpurascens Extracts on Anticholinergic, Antidiabetic, Antibacterial Potential, and Antioxidant Capacity

Is Effective Recruitment Strategy Critical to Assess Brain Cognitive Function of Super Agers in Rural West Texas

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