An Inclusion Compound of the Anticonvulsant Sodium Valproate into α-Cyclodextrin: Physico-Chemical Characterization

Characterization and Comparison of the Solid State Inclusion Compounds of alfa-, beta-Cyclodextrins and its 2-Hydroxypropyl Derivatives with Uracil and 5-fluorouracil

“…As can be seen in figures 1 and 2, the DSC curve of pure αCD shows a broad endothermic peak between 34 and 130 o C corresponding to its dehydration and reorganization and a thermal effect starting at 298 o C which is attributed to a melting -decomposition process of αCD, [8]. For βCD the loss of water emerged between 50 and 110 o C and the small peak at around the temperature of 240 o C corresponds to an irreversible solid-solid phase transition which is finally followed by a degradation process starting at around the temperature of 290 o C. This thermal behavior of βCD is consistent with literature, [9,10].…”

Physicochemical Characterization of Cyclodextrin–Drug Interactions in the Solid State and the Effect of Water on These Interactions

“…In addition, they listed and discussed in detail the PXRD data of several parent CDs with and without water. Apparently, different numbers of water molecules can influence the molecular arrangements of α‐, β‐, and γ‐CD in their respective hydrates . In the past, intermolecular interactions between CDs and guest molecules have been extensively investigated .…”

“…Apparently, different numbers of water molecules can influence the molecular arrangements of "-, $-, and (-CD in their respective hydrates. 43,[52][53][54][55][56][57][58][59][60] In the past, intermolecular interactions between CDs and guest molecules have been extensively investigated. 43,61 The formation of inclusion complexes is driven by noncovalent interactions, such as van der Waals and hydrogen bonding, as discussed in the introduction.…”

P-Dimethylaminobenzaldehyde semicarbazone: The bonding abilities of imine nitrogen atom

“…The aryl semicarbazones show inter alia the anticonvulsant activity [9][10][11]. It is believed that the interaction mechanism at the binding site is related to the presence and properties of hydrogen-bonding area and hydrophobic binding site, as well as the presence of electron-rich atom/group attached at the para position of the aryl ring and electron donor moiety.…”