“… 23 For sure, medical history, physical examination, and US features must be interpreted altogether (in doubtful cases) 23 . Last, detailed characterization of the sonographic pattern of the MTrP is paramount for the differential diagnosis, that is, with regard to intramuscular neoformations originating from muscular, 24 connective, 25 neural, 26 or vascular 27,28 tissues. Of note, such pathologies may show some sonographic “red flags” such as irregular edges infiltrating the surrounding tissues, localized mass effect with compression of the nearby structures, mixed inner echotexture with alternation of solid and fluid components due to necrotic foci, intralesional calcifications, and atypical perfusion pattern in color/power Doppler imaging 24–28 …”