An Inception Cohort Study Assessing the Role of Pneumococcal and other Bacterial Pathogens in Children with Influenza and ILI and a Clinical Decision Model for Stringent Antibiotic Use

Tief, Franziska; Hoppe, Christian; Seeber, Lea; Obermeier, Patrick; Chen, Xi; Karsch, Katharina; Mühlhans, Susann; Adamou, Eleni; Conrad, Tim; Béresniak, Ariel; Schweiger, Brunhilde; Adam, Thomas C.; Rath, Barbara

doi:10.3851/imp3034

Cited by 16 publications

(42 citation statements)

References 54 publications

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“…The validation project was conducted from March 2012–August 2014 in the context of quality management (QM) programs at the Charité Department of Pediatrics in collaboration with the Robert Koch Institute in Berlin, Germany, as described previously (Rath et al, 2013, Chen et al, 2014, Karsch et al, 2015, Obermeier et al, 2016, Tief et al, 2016). Infants and children (0–18 years of age) presenting to the ED or hospitalized with suspected vaccine-preventable diseases (e.g.…”

Section: Methodsmentioning

confidence: 99%

Educating parents about the vaccination status of their children: A user-centered mobile application

Seeber

Conrad

Hoppe

et al. 2017

Preventive Medicine Reports

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Parents are often uncertain about the vaccination status of their children. In times of vaccine hesitancy, vaccination programs could benefit from active patient participation. The Vaccination App (VAccApp) was developed by the Vienna Vaccine Safety Initiative, enabling parents to learn about the vaccination status of their children, including 25 different routine, special indication and travel vaccines listed in the WHO Immunization Certificate of Vaccination (WHO-ICV). Between 2012 and 2014, the VAccApp was validated in a hospital-based quality management program in Berlin, Germany, in collaboration with the Robert Koch Institute. Parents of 178 children were asked to transfer the immunization data of their children from the WHO-ICV into the VAccApp. The respective WHO-ICV was photocopied for independent, professional data entry (gold standard). Demonstrating the status quo in vaccine information reporting, a Recall Group of 278 parents underwent structured interviews for verbal immunization histories, without the respective WHO-ICV. Only 9% of the Recall Group were able to provide a complete vaccination status; on average 39% of the questions were answered correctly. Using the WHO-ICV with the help of the VAccApp resulted in 62% of parents providing a complete vaccination status; on average 95% of the questions were answered correctly. After using the VAccApp, parents were more likely to remember key aspects of the vaccination history. User-friendly mobile applications empower parents to take a closer look at the vaccination record, thereby taking an active role in providing accurate vaccination histories. Parents may become motivated to ask informed questions and to keep vaccinations up-to-date.

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Section: Methodsmentioning

confidence: 99%

Educating parents about the vaccination status of their children: A user-centered mobile application

Seeber

Conrad

Hoppe

et al. 2017

Preventive Medicine Reports

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“…The ViVI Score mobile application provides a uniform approach to defining ad hoc disease severity at any given time point, based on extensive literature review as well as WHO Criteria for uncomplicated and complicated influenza . The ViVI Score consists of nine unweighted symptoms/items reflecting uncomplicated disease (DSU1‐9) plus 13 weighted items reflecting complicated disease (DSC 1‐13) resulting in overall scores ranging from 0‐48 . Data formats and terminologies are fully compliant with Clinical Data Interchange Standards Consortium (CDISC) and regulatory requirements …”

Section: Methodsmentioning

confidence: 99%

“…The severity assessments were performed by independent QI staff in patients with influenza‐like illness (ILI), at the time of initial presentation to the emergency room (ER)/hospital, that is prior to any treatment decisions . Assessments included the ViVI Disease Severity Score, the ViVI Risk Factor Score (consisting of 16 unweighted items) and three simple yes/no questions regarding planned treatment with antibiotics and/or antivirals and the patient's current flu vaccination status.…”

Section: Methodsmentioning

confidence: 99%

“…For example, mortality appears to be higher in Eastern Europe, for reasons yet unknown . Improved understanding of regional differences will require validated, standardized disease severity measures . Standardized severity measures will allow cross‐cohort comparison and a precision medicine approach to managing individual influenza infections in different risk groups .…”

Section: Introductionmentioning

confidence: 99%

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Partnering for enhanced digital surveillance of influenza‐like disease and the effect of antivirals and vaccines (PEDSIDEA)

Rath

Maltezou

Papaevangelou

et al. 2019

Influenza Resp Viruses

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Background Standardised clinical outcome measures are urgently needed for the surveillance of influenza and influenza‐like illness (ILI) based on individual patient data (IPD). Objectives We report a multicentre prospective cohort using a predefined disease severity score in routine care. Patients/Methods The Vienna Vaccine Safety initiative (ViVI) Disease Severity Score (“ViVI Score”) was made available as an android‐based mobile application to three paediatric hospitals in Berlin and Athens between 2013 and 2016. Healthcare professionals assessed ILI patients at the point of care including severity, risk factors and use of antibiotics/antivirals/vaccines. RT‐PCR for influenza A/B viruses was performed at the Hellenic Pasteur Institute and the Robert Koch Institute. PCR testing was blinded to severity scoring and vice versa. Results A total of 1615 children aged 0‐5 years (54.4% males) were assessed at the three sites. The mean age was 1.7 years (SD 1.5; range 0‐5.9). The success rate (completion of the scoring without disruption to the ER workflow) was 100%. ViVI Disease Severity Scores ranged from 0 to 35 (mean 13.72). Disease severity in the Berlin Cohort was slightly higher (mean 15.26) compared to the Athens Cohorts (mean 10.86 and 11.13). The administration of antibiotics was most prevalent in the Berlin Cohort, with 41.2% on antibiotics (predominantly cefuroxime) as opposed to only 0.5% on neuraminidase inhibitors. Overall, Risk‐adjusted ViVI Scores were significantly linked to the prescription of both, antibiotics and antivirals. Conclusions The Risk‐adjusted ViVI Score enables a precision medicine approach to managing ILI in multicentre settings. Using mobile applications, severity data will be obtained in real time with important implications for the evaluation of antiviral/vaccine use.

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“…Эта проблема изучается многими исследователями, особенно у детей [22,23]. При этом подчеркива-ется, что вирусные инфекции дыхательных ин-фекций встречаются очень часто, а их проявления варьируют от простой простуды до угрожающих жизни инфекционных заболеваний [24][25][26].…”

Section: респираторные коинфекции с позиций бактериально вирусных взаunclassified

Viral and bacterial coinfection as a global problem of modern medicine

Балмасова

Петровна²,

Malova

et al. 2018

Vestn. Ross. univ. družby nar., Ser. Med.

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1Московский государственный медико-стоматологический университет им. А.И.Евдокимова, Москва, Россия; 2 Российский университет дружбы народов, Москва, РоссияКоинфекции в современном мире приобретают все большее медико-социальное значение не только в связи с их широкой распространенностью, но и потому, что до настоящего времени не сформировано надежного методологиче-ского подхода ни к их клинической оценке, ни к лечению и профилактике. В основе такого методологического под-хода должно лежать знание о механизмах взаимодействия патогенных микроорганизмов друг с другом -прямых и/или опосредованных иммунной системой. Наиболее частыми патогенами при коинфицировании служат бактерии и вирусы, ассоциация которых не только способствует более тяжелому течению инфекционного процесса, но и значительно повыша-ет частоту его осложнений и летальных исходов. В данном обзоре на примере респираторных инфекций, опухолевых процессов, ассоциантов вируса иммунодефицита человека рассматриваются формы взаимодействия патогенов при бакте-риально-вирусных коинфекциях, показывающие их высокое разнообразие. В числе механизмов взаимодействия коинфи-цирующих агентов особое внимание уделяется влиянию вирусов на токсинообразование бактерий, а бактерий -на ин-фекционность вирусов. Коинфицирующие микроорганизмы способствуют сочетанному преодолению ими эпителиального барьера, могут взаимовыгодно модифицировать функции клеток иммунной системы и способствовать ускользанию этих патогенов от иммунного ответа. Установлено, что экспрессия генов целого ряда онкогенных вирусов и ВИЧ регулируется эпигеномными изменениями, вызванными бактериями, что приводит к канцерогенному эффекту. Показано, что разно-образие бактериально-вирусных взаимодействий при коинфицировании не только вызывает необходимость новых под-ходов к их своевременному распознаванию и контролю, но и порождает новые биотехнологии и стратегии борьбы с ко-инфицированием, развитию которых во всем мире уделяется огромное внимание.Ключевые слова: коинфекция, вирусно-бактериальные взаимодействия, респираторные инфекции, канцерогенез, ВИЧ-ассоциированные бактерии, лечение и профилактика коинфекций Ответственный за переписку: Балмасова Ирина Петровна, доктор медицинских наук, профессор. Московский государственный медико-стоматологи-ческий университет им. А.И. Евдокимова, 127473, г. Москва,

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An Inception Cohort Study Assessing the Role of Pneumococcal and other Bacterial Pathogens in Children with Influenza and ILI and a Clinical Decision Model for Stringent Antibiotic Use

Cited by 16 publications

References 54 publications

Educating parents about the vaccination status of their children: A user-centered mobile application

Educating parents about the vaccination status of their children: A user-centered mobile application

Partnering for enhanced digital surveillance of influenza‐like disease and the effect of antivirals and vaccines (PEDSIDEA)

Viral and bacterial coinfection as a global problem of modern medicine

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