An Incentive-Based Program Coupled with Sildenafil Provides Enhanced Success of Smoking Cessation Associated with an Accelerated Loss of CT Assessed Smoking-Associated Lung Density (Inflammation) and Improved DLCO

Liu, Y.; Comellas, A.P.; Kaczka, David W.; Motahari, A.; Lee, C.; Gerke, Alicia K.; Wilson, Jeffrey S.; Salisbury, Sue Ellen; O'Connel-Moore, D.; Philibert, Robert A.; Hoffman, Eric A.

doi:10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a7556

Cited by 3 publications

(2 citation statements)

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“…The 39 subjects who participated in this study were part of a 90-day incentive-based smoking cessation program (National Clinical Trials NCT02682147) whose overarching purpose was to understand the relationship between smoking cessation and pulmonary inflammation [ 14 ]. Each potential participant, who was alerted to the study by a series of advertisements to patients and staff of the University of Iowa, had to complete a brief online survey in which they reported smoking at least 10 cigarettes per day with a total of five or more pack-years of lifetime consumption in order to qualify for the study.…”

Section: Methodsmentioning

confidence: 99%

The Reversion of the Epigenetic Signature of Coronary Heart Disease in Response to Smoking Cessation

Philibert

Moody

Philibert

et al. 2023

Genes

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Coronary heart disease (CHD) is the leading cause of death worldwide. However, current diagnostic tools for CHD, such as coronary computed tomography angiography (CCTA), are poorly suited for monitoring treatment response. Recently, we have introduced an artificial-intelligence-guided integrated genetic–epigenetic test for CHD whose core consists of six assays that determine methylation in pathways known to moderate the pathogenesis of CHD. However, whether methylation at these six loci is sufficiently dynamic to guide CHD treatment response is unknown. To test that hypothesis, we examined the relationship of changes in these six loci to changes in cg05575921, a generally accepted marker of smoking intensity, using DNA from a cohort of 39 subjects undergoing a 90-day smoking cessation intervention and methylation-sensitive digital PCR (MSdPCR). We found that changes in epigenetic smoking intensity were significantly associated with reversion of the CHD-associated methylation signature at five of the six MSdPCR predictor sites: cg03725309, cg12586707, cg04988978, cg17901584, and cg21161138. We conclude that methylation-based approaches could be a scalable method for assessing the clinical effectiveness of CHD interventions, and that further studies to understand the responsiveness of these epigenetic measures to other forms of CHD treatment are in order.

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Section: Methodsmentioning

confidence: 99%

The Reversion of the Epigenetic Signature of Coronary Heart Disease in Response to Smoking Cessation

Philibert

Moody

Philibert

et al. 2023

Genes

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“…The study protocol was part of a larger effort to understand the effects of smoking on pulmonary inflammation [ 22 ]. The protocol included one intake visit and three consecutive monthly follow-up visits.…”

Section: Methodsmentioning

confidence: 99%

Alcohol Use Intensity Decreases in Response to Successful Smoking Cessation Therapy

Philibert

Dawes

Philibert

et al. 2021

Genes

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Smokers frequently drink heavily. However, the effectiveness of smoking cessation therapy for those with comorbid alcohol abuse is unclear, and the content of smoking cessation programs often does not address comorbid alcohol consumption. In order to achieve a better understanding of the relationship between changes in rate of smoking to the change in intensity of alcohol consumption, and the necessity for alcohol-specific programming for dual users, we quantified cigarette and alcohol consumption in 39 subjects undergoing a 3-month contingency management smoking cessation program using recently developed DNA methylation tools. Intake alcohol consumption, as quantified by the Alcohol T Score (ATS), was highly correlated with cg05575921 smoking intensity (adjusted R2 = 0.49) with 19 of the 39 subjects having ATS scores indicative of Heavy Alcohol Consumption. After 90 days of smoking cessation therapy, ATS values decreased with the change in ATS score being highly correlated with change in cg05575921 smoking intensity (adjusted R2 = 0.60), regardless of whether or not the subject managed to completely quit smoking. We conclude that alcohol consumption significantly decreases in response to successful smoking cessation. Further studies to determine whether targeted therapy focused on comorbid alcohol use increases the success of smoking cessation in those with dual use should be explored.

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Bridging the Task Barriers: Online Knowledge Distillation Across Tasks for Semi-supervised Mediastinal Segmentation in CT

Chaudhary,

Hosseini,

Barr

et al. 2023

Machine Learning in Medical Imaging

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An Incentive-Based Program Coupled with Sildenafil Provides Enhanced Success of Smoking Cessation Associated with an Accelerated Loss of CT Assessed Smoking-Associated Lung Density (Inflammation) and Improved DLCO

Cited by 3 publications

References 0 publications

The Reversion of the Epigenetic Signature of Coronary Heart Disease in Response to Smoking Cessation

The Reversion of the Epigenetic Signature of Coronary Heart Disease in Response to Smoking Cessation

Alcohol Use Intensity Decreases in Response to Successful Smoking Cessation Therapy

Bridging the Task Barriers: Online Knowledge Distillation Across Tasks for Semi-supervised Mediastinal Segmentation in CT

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