Abstract:An autonomous endogenous time-keeping is ubiquitous across many living organisms known as circadian clock when it has a period of about 24 hours. Interestingly, the fundamental design principle with a network of interconnected negative and positive feedback loops is conserved through evolution, although the molecular components differ. Filamentous fungus Neurospora crassa is a well established chrono-genetics model organism to investigate the underlying mechanisms. The core negative feedback loop of the clock … Show more
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