An Inactivated Cell-Culture Vaccine against Yellow Fever

Monath, Thomas P.; Fowler, Elizabeth; Johnson, Casey; Balser, John; Morin, Merribeth J.; Sisti, Maggie; Trent, Dennis W.

doi:10.1056/nejmoa1009303

Cited by 99 publications

(66 citation statements)

References 12 publications

(11 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The development of an inactivated vaccine would be a solution for the immunosuppressed individuals. However, killed vaccines may have disadvantages as risk of incomplete inactivation, change in immunogenic properties of the virus, and the use of multiple doses [158,159]. The relationship between vaccines and autoimmunity is bidirectional.…”

Section: Discussionmentioning

confidence: 99%

Vaccination and autoimmune diseases: is prevention of adverse health effects on the horizon?

et al. 2017

View full text Add to dashboard Cite

Autoimmune diseases, including multiple sclerosis and type 1 diabetes mellitus, affect about 5% of the worldwide population. In the last decade, reports have accumulated on various autoimmune disorders, such as idiopathic thrombocytopenia purpura, myopericarditis, primary ovarian failure, and systemic lupus erythematosus (SLE), following vaccination. In this review, we discuss the possible underlying mechanisms of autoimmune reactions following vaccinations and review cases of autoimmune diseases that have been correlated with vaccination. Molecular mimicry and bystander activation are reported as possible mechanisms by which vaccines can cause autoimmune reactions. The individuals who might be susceptible to develop these reactions could be especially not only those with previous post-vaccination phenomena and those with allergies but also in individuals who are prone to develop autoimmune diseases, such as those with a family history of autoimmunity or with known autoantibodies, and the genetic predisposed individuals.Further research is encouraged into the direct associations between vaccines and autoimmune conditions, and the biological mechanisms behind them.

show abstract

Section: Discussionmentioning

confidence: 99%

Vaccination and autoimmune diseases: is prevention of adverse health effects on the horizon?

et al. 2017

View full text Add to dashboard Cite

show abstract

“…One approach is using inactivated YF 17D virus, which showed good immunogenicity in pre-clinical and clinical studies 43 ; and we are also following this trend by producing the Envelope E protein in plants, in collaboration with the Fraunhofer Institute in the US. Some challenges being tackled at this stage are the improvement of antigen expression and the study of its immunogenicity using new adjuvants.…”

Section: Perspectivesmentioning

confidence: 99%

Serious adverse events associated with yellow fever vaccine

Martins

Leal²,

Homma³

2015

Human Vaccines & Immunotherapeutics

View full text Add to dashboard Cite

“…There is no consensus on the titration conferring immunity. However, the values used as positive, i.e., values more than 10 are well accepted in the literature 10,11,19,21,22 .…”

Section: Discussionmentioning

confidence: 99%

“…The samples were tested in serial dilutions (range, 1:05-1:640) and compared to an average of 20 plaque-forming units of yellow fever virus. Seropositivity was considered when the titer was above or equal to 1:10, whereas when the titer was below 1:10, seronegativity was considered 10,11 .…”

Section: Clinical-serological Surveymentioning

confidence: 99%

Serologic assessment of yellow fever immunity in the rural population of a yellow fever-endemic area in Central Brazil

Machado

Vasconcelos

Silva

et al. 2013

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

Introduction:The yellow fever epidemic that occurred in 1972/73 in Central Brazil surprised the majority of the population unprotected. A clinical-epidemiological survey conducted at that time in the rural area of 19 municipalities found that the highest (13.8%) number of disease cases were present in the municipality of Luziânia, State of Goiás. Methods: Thirty-eight years later, a new seroepidemiological survey was conducted with the aim of assessing the degree of immune protection of the rural population of Luziânia, following the continuous attempts of public health services to obtain vaccination coverage in the region. A total of 383 volunteers, aged between 5 and 89 years and with predominant rural labor activities (75.5%), were interviewed. The presence of antibodies against the yellow fever was also investigated in these individuals, by using plaque reduction neutralization test, and correlated to information regarding residency, occupation, epidemiological data and immunity against the yellow fever virus. Results: We found a high (97.6%) frequency of protective titers (>1:10) of neutralizing antibodies against the yellow fever virus; the frequency of titers of 1:640 or higher was 23.2%, indicating wide immune protection against the disease in the study population. The presence of protective immunity was correlated to increasing age. Conclusions: This study reinforces the importance of surveys to address the immune state of a population at risk for yellow fever infection and to the surveillance of actions to control the disease in endemic areas.

show abstract

An Inactivated Cell-Culture Vaccine against Yellow Fever

Cited by 99 publications

References 12 publications

Vaccination and autoimmune diseases: is prevention of adverse health effects on the horizon?

Vaccination and autoimmune diseases: is prevention of adverse health effects on the horizon?

Serious adverse events associated with yellow fever vaccine

Serologic assessment of yellow fever immunity in the rural population of a yellow fever-endemic area in Central Brazil

Contact Info

Product

Resources

About