An in vivo study of the host tissue response to subcutaneous implantation of PLGA- and/or porcine small intestinal submucosa-based scaffolds

Kim, Moon Suk; Ahn, Hyun Hee; Shin, Yu Na; Cho, Mi Hee; Khang, Gilson; Lee, Hai Bang

doi:10.1016/j.biomaterials.2007.08.014

Cited by 190 publications

(124 citation statements)

References 35 publications

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“…[4][5][6][7][8]). Although PLA has been approved for these applications [4,9], several studies have also shown that contact of some of the PLA based products with human body is associated with biocompatibility problems including inducing nodules and foreign-body granulomas [10] and post-implantation inflammation [11]. PLA hydrophobicity has also been shown to affect cell attachment, viability and proliferation [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Bioactive albumin functionalized polylactic acid membranes for improved biocompatibility

Nyanhongo

Rodríguez

Prasetyo

et al. 2013

Reactive and Functional Polymers

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Section: Introductionmentioning

confidence: 99%

Bioactive albumin functionalized polylactic acid membranes for improved biocompatibility

Nyanhongo

Rodríguez

Prasetyo

et al. 2013

Reactive and Functional Polymers

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“…SIS can provide structural support, and thus stimulates rapid host tissue ingrowth and, ultimately, new bone formation [26,27]. Despite the good results obtained using SIS, limited studies have investigated the SIS sponge as a biomaterial for bone regeneration.…”

Section: Discussionmentioning

confidence: 99%

Osteoinductive potential of small intestinal submucosa/ demineralized bone matrix as composite scaffolds for bone tissue engineering

et al. 2010

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Background: Demineralized bone matrix (DBM) is extensively used in orthopedic, periodontal, and maxillofacial application and investigated as a material to induce new bone formation. Small intestinal submucosa (SIS) derived from the submucosa layer of porcine intestine has widely utilized as biomaterial with minimum immune response. Objectives: Determine the osteoinductive potential of SIS, DBM, SIS/DBM composites in the in vitro cell culture and in vivo animal bioassays for bone tissue engineering. Materials and methods: Human periosteal (HPO) cells were treated in the absence or presence SIS, DBM, and SIS/DBM. Cell proliferation was examined by direct cell counting. Osteoblast differentiation of the HPO cells was analyzed with alkaline phosphatase activity assay. The Wistar rat muscle implant model was used to evaluate the osteoinductive potential of SIS, DBM, and SIS/DBM composites. Results: HPO cells could differentiate along osteogenic lineage when treated with either DBM or SIS/DBM. SIS/ DBM had a tendency to promote more cellular proliferation and osteoblast differentiation than the other treatments. In Wistar rat bioassay, SIS showed no new bone formation and the implants were surrounded by fibrous tissues. DBM demonstrated new bone formation along the edge of old DBM particles. SIS/DBM composite exhibited high osteoinductivity, and the residual SIS/DBM was surrounded by osteoid-like matrix and newly formed bone. Conclusion: DBM and SIS/DBM composites could retain their osteoinductive capability. SIS/DBM scaffolds may provide an alternative approach for bone tissue engineering.

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“…SIS is an acellular, naturally occurring collagenous extracellular matrix material derived from the submucosa of porcine small intestine that has been reported to contain various bioactive molecules [7]. An SIS sponge manufactured from SIS can provide a three-dimensional structural scaffold, and thus support rapid host tissue ingrowth [10,28] and, ultimately, new bone formation. Despite the good results obtained using SIS, few studies have evaluated the SIS sponge as a scaffold for repairing shaped bones.…”

Section: Discussionmentioning

confidence: 99%

“…Small intestine submucosa (SIS), derived from the submucosal layer of porcine intestine, is an acellular, naturally occurring collagenous extracellular matrix material [7][8][9][10][11]. SIS consists of types I and III collagens, which together comprise greater than 90% of the total collagen content, and small amounts of types IV, V and VI collagens.…”

Section: Introductionmentioning

confidence: 99%

Small intestine submucosa sponge for in vivo support of tissue-engineered bone formation in the presence of rat bone marrow stem cells

et al. 2010

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An in vivo study of the host tissue response to subcutaneous implantation of PLGA- and/or porcine small intestinal submucosa-based scaffolds

Cited by 190 publications

References 35 publications

Bioactive albumin functionalized polylactic acid membranes for improved biocompatibility

Bioactive albumin functionalized polylactic acid membranes for improved biocompatibility

Osteoinductive potential of small intestinal submucosa/ demineralized bone matrix as composite scaffolds for bone tissue engineering

Small intestine submucosa sponge for in vivo support of tissue-engineered bone formation in the presence of rat bone marrow stem cells

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