An In Vivo Rat Study of Bioresorbable Mg-2Zn-2Ga Alloy Implants

Abstract

In the present study, pins made from the novel Mg-2Zn-2Ga alloy were installed within the femoral bones of six Wistar rats. The level of bioresorption was assessed after 1, 3, and 6 months by radiography, histology, SEM, and EDX. Significant bioresorption was evident after 3 months, and complete dissolution of the pins occurred at 6 months after the installation. No pronounced gas cavities could be found at the pin installation sites throughout the postoperative period. The animals’ blood parameters showed no signs of inflammation or toxication. These findings are sufficiently encouraging to motivate further research to broaden the experimental coverage to increase the number of observed animals and to conduct tests involving other, larger animals.

Mg alloys with antitumor and anticorrosion properties for orthopedic oncology: A review from mechanisms to application strategies

“… 38 Moreover, Mg alloys are biodegradable osteosynthesis materials and can degrade progressively in the physiological environment and be replaced by new bone finally, obviating the need of secondary surgery to remove residual parts after bone healing, which could effectively reduce medical costs and patient suffering. 39–41 Many innovative Mg-based products have been developed, including intramedullary nail, scaffold, artificial bandage, etc., which significantly promote new bone formation in the repair of bone defects. 42–45 Mg ions released from such biomaterials could upregulating the expression of calcitonin gene-related peptide (CGRP) and vascular endothelial growth factor (VEGF), which finally accelerate defect bone regeneration.…”