An in-vivo pilot study into the effects of FDG-mNP in cancer in mice

Aras, Ömer; Pearce, Gillian; Watkins, Adam; Nurili, Fuad; Medine, E. Ilker; Guldu, Ozge Kozgus; Tekin, Volkan; Wong, John; Ma, Xianghong; Ting, Richard; Ünak, Perıhan; Akın, Oğuz

doi:10.1371/journal.pone.0202482

Cited by 9 publications

(23 citation statements)

References 18 publications

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“…The FT-IR spectra confirmed the peaks at around 3369 cm -1 from O-H stretching and 550 cm -1 from the Fe-O band of MNPs (Figure 3). Results are agree with our previous data [8,10,14,21]. The difference between lines is even more significant since an increased absorbance time is expected to cause more cell death.…”

Section: Structural Properties Of Mnps and Fdg-mnpssupporting

confidence: 92%

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Hepton

Harper

et al. 2021

Asian J. Nanosci. Mater.

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Iron nanoparticles (MNPs) are known to induce membrane damage and apoptosis of cancer cells. In our study we determined whether FDG coupled with iron oxide magnetic nanoparticles can exert the same destructive effect on cancer cells. This research study presents data involving NIC-H727 human lung, bronchus epithelial cells exposed to conjugated fluorodeoxyglucose conjugated with iron-oxide magnetic nanoparticles and indocyanine green (ICG) dye (FDG-MNP-ICG), with and without the application of a magnetic field. Cell viability inferred from MTT assay revealed that FDG-MNPs had no significant toxicity towards noncancerous NIC-H727 human lung, bronchus epithelial cells. However, percentage cell death was much higher using a magnetic field, for the concentration of FDG-MNP-ICC used in our experiments. Magnetic field was able to destroy cells containing MNPs, while MNPs alone had significantly lower effects. Additionally, MNPs alone in these low concentrations had less adverse effects on healthy (non-target) cells.

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Section: Structural Properties Of Mnps and Fdg-mnpssupporting

confidence: 92%

“…MNPs were synthesized, coated in silica, and fabricated with TEOS (tetraethyl orthosilicate). These modified MNPs were then conjugated with [ 19 F]FDG, optically labelled with ICG (indocyanine green) and characterized similarly as described in our previous reports [8,10,12,21].…”

Section: Synthesis and Characterization Of Mnps And Fdg-mnpsmentioning

confidence: 99%

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Hepton

Harper

et al. 2021

Asian J. Nanosci. Mater.

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“…Overall, the structural properties of synthesized mNPs and FDG-mNPs are in line with findings from previous studies [7,14,15,16].…”

Section: Structural Properties Of Mnps and Fdg-mnpssupporting

confidence: 90%

“…The modified mNPs were conjugated with nonradiactive F using NaF. mNPs and FDG-mNPs characterized similarly as described in our previous reports [10,14,15,16]. Briefly, the hydrodynamic diameter of mNPs or FDG-mNPs was measured using DLS.…”

Section: Synthesis and Characterization Of Fdg-mnpsmentioning

confidence: 99%

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Budiyo

Horsnzky

et al. 2021

Asian J. Nanosci. Mater.

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We present a report regarding the cytotoxic effects of iron-based magnetic nanoparticles conjugated with fluorodeoxyglucose (FDG-mNPs) on the viability of NCI-H727 and SH-SY5Y cancer cells. MTT assays were performed to determine cell viability in treated cancer cells grown under standard 2D culture conditions. FDG-mNP concentrations of 0.075 mg/mL, 0.15 mg/mL, and 0.3 mg/mL decreased mean cell viability of NCI-H727 cells to 92.5%, 82.9%, and 75% respectively. FDG-mNPs was also shown to have a detrimental effect on the viability of SY5Y cells: a decrease of 5.7%, 18.6%, and 36.4% was found for SY5Y cells treated with 0.075 mg/mL, 0.15 mg/mL, and 0.3 mg/mL concentrations of FDG-mNPs, respectively. When NCI-H727 and SH-SY5Y cancer cells were grown as 3D spheroids, morphology was visibly changed and the number of viable cells was decerased in spheroids treated with FDG-mNPs compared with untreated spheroids. The results of our study demonstrated that FDG-mNP has toxic effects on NCI-H7272 and SY5Y cancer cells, and we conclude that conjugated FDG-mNPs are promising in the development of clinical applications for the destruction of cancer cells.

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“…Kuantum noktaları, demir dahil olmak üzere inorganik nanopartiküller oksit nanopartiküller, altın nanoyapılar ve dönüştürme nanofosforları (5,6,7,8,9,10,11),…”

Section: Birden Fazla Görüntüleme Sisteminde Kullanılabilen Görüntüleunclassified

Imaging Probes Used in Multiple Imaging System (Dual Modality Probes)

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ÖzNowadays, with the increasing interest in personalized medicine and translational research, the need to develop disease-specific nanoprobes has arisen, leading to the development of systems that simultaneously perform multiple imaging such as positron emission tomography (PET)/computerized tomography (CT), single photon emission computerized tomography (SPECT)/CT or SPECT/magnetic resonance imaging (MRI), and PET/MRI in the biomedical field. These systems revealed the need to develop new molecular systems or nanotechnological drugs capable of performing multiple functions that could give the same image. Thus, the emergence of hybrid cameras combining the MRI with SPECT or PET in the multi-module hybrid technology has aroused increased attention to the development of multimodality imaging probes. As a result, the need to develop diseasespecific nanoprobes has arisen with the increasing interest in personalized medicine and translational research, and focus to radionuclides labeled nanoparticles of PET/SPECT has increased in the biomedical field. The biggest challenges are: the development of easy-to-use, high-throughput radiolabeling strategies to improve the imaging stability, increased sensitivity for early stage sensitivity for the disease, and the optimization of in vivo pharmacokinetics. The aim of this article is to briefly summarize the main applications of imaging probes that can be used in the multiple mode (dualmode) system for different systems such as cardiovascular imaging, lung diagnosis, and tumor therapy.

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An in-vivo pilot study into the effects of FDG-mNP in cancer in mice

Cited by 9 publications

References 18 publications

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Imaging Probes Used in Multiple Imaging System (Dual Modality Probes)

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