Abstract:Background
Tumorigenesis is a complex and multistep process characterized by the progressive acquisition of various hallmarks, including unlimited proliferation, resistance to apoptosis, and increased invasiveness and metastasis. However, the molecular mechanisms underlying tumorigenesis remain poorly understood.
Methods
An in vivo genome-wide CRISPR–Cas9 screen was employed to identify tumor suppressor genes (TSG). The expression correlation analysis for candidate TSGs was performed in normal and cancer cel… Show more
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