An in vivo evaluation of bonding ability of comprehensive antibacterial adhesive system incorporating MDPB

Imazato, Satoshi; Tay, Franklin R.; Kaneshiro, Andrea V.; Takahashi, Yusuke; Ebisu, Shigeyuki

doi:10.1016/j.dental.2006.01.005

Cited by 120 publications

(128 citation statements)

References 16 publications

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“…The mechanical properties of the carrier material may deteriorate, and the materials released may be toxic if not properly controlled (8,9). To overcome the disadvantages of agent-releasing composites, some researchers have reported finishing several resin-based restorations with a composite resin, which is incorporated with a type of quaternary ammonium salt monomer, methacryloyloxydodecyl pyridinium bromide (MDPB), which exhibits antibacterial activities without leach-out of the incorporated monomer from the material (10)(11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

Antibacterial effects of three experimental quaternary ammonium salt (QAS) monomers on bacteria associated with oral infections

et al. 2008

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The aim of this study was to test the antibacterial effects of three experimental quaternary ammonium salt monomers in order to evaluate their potential applications as dental materials. In vitro susceptibility testing of the monomers was performed by the broth dilution method on bacteria associated with oral infections: Streptococcus mutans ATCC 25175, Actinomyces viscosus ATCC 15987, Staphylococcus aureus ATCC 29213 and Lactobacillus casei ATCC 393. The time-kill kinetics of the monomer with relatively higher antibacterial activity against S. mutans were also investigated. It was found that all the tested bacteria strains were susceptible to the three monomers, among which methacryloxylethyl cetyl ammonium chloride (DMAE-CB) exhibited the lowest minimal inhibitory concentrations, ranging from 1.2 to 4.8 µg/ml. The time-kill curve showed that DMAE-CB achieved 99.44% killing at 19.2 µg/ml (4 times the minimal bactericidal concentration) against S. mutans after 1 min and 100% killing within 10 min of contact. This result indicates that the quaternary ammonium salt monomer DMAE-CB may be a candidate antibacterial agent for incorporation into dental restorative materials. (J. Oral Sci. 50, [323][324][325][326][327] 2008) Keywords: quaternary ammonium salt; antibacterial effect; oral pathogenic bacteria; monomer; dental material.

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Section: Introductionmentioning

confidence: 99%

Antibacterial effects of three experimental quaternary ammonium salt (QAS) monomers on bacteria associated with oral infections

et al. 2008

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“…In particular, 12-methacryloyloxydodecylpyridinium bromide (MDPB) has been incorporated into dental adhesives [16][17][18] , resulting in the successful commercialization of the world's first antibacterial dental adhesive system 13) . The combined use of CPtN with antibacterial adhesives containing quaternary ammonium-based monomers may enhance their clinical usefulness by improving bonding properties and biocompatibility, thereby contributing to durable restoration.…”

Section: Introductionmentioning

confidence: 99%

Assessment of bactericidal effects of quaternary ammonium-based antibacterial monomers in combination with colloidal platinum nanoparticles

Izutani

Imazato

et al. 2012

Dent. Mater. J.

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Pretreatment of dentin using colloidal platinum nanoparticles (CPtN) can enhance the bond strength of dentin adhesives. However, the combination of CPtN, which is negatively charged, with cationic monomer-containing adhesive may reduce the antibacterial activity of the original material. Thus, the purpose of this study was to assess the effect of CPtN on the bactericidal activity of two cationic antibacterial monomers, 12-methacryloyloxydodecylpyridinium bromide (MDPB) and methacryloxylethyl cetyl dimethyl ammonium chloride (DMAE-CB). The rapid killing effects of the two monomers against planktonic or attached Streptococcus mutans in the presence or absence of CPtN were examined by viable cell counts. The measurement of minimum inhibitory and bactericidal concentrations demonstrated that CPtN up to 2.5 mM has no antibacterial activity. In the absence of CPtN, rapid killing of both planktonic and attached Streptococcus mutans were achieved by the two cationic monomers. Combination with 0.1 mM CPtN did not reduce the bactericidal effects of the two monomers, indicating that CPtN may be used as a pretreatment with antibacterial adhesives.

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“…4,5,6,7 The results of the present study indicate that METAC is a promising antibacterial agent when added to an adhesive system.…”

Section: Discussionmentioning

confidence: 70%

“…2,3 Thus, antibacterial agents have been added to adhesive systems as an effective dental treatment strategy. 4,5,6,7 The use of antibacterial agents leads to inactivation of bacteria and may hamper dental caries progression. 8 Furthermore, the antibacterial property of adhesive systems could bring an additional benefit to the conservative management of carious Fabrício Mezzomo COLLARES (a) Vicente Castelo Branco LEITUNE (a) Patrícia FRANKEN (a) Clarissa Fatturi PAROLLO (b) Fabrício Aulo OGLIARI (c) Susana Maria Werner SAMUEL (a) lesions 9,10,11 by improving the success and longevity of restorations.…”

Section: Introductionmentioning

confidence: 99%

Influence of addition of [2-(methacryloyloxy)ethyl]trimethylammonium chloride to an experimental adhesive

et al. 2017

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Influence of addition of [2-(methacryloyloxy)ethyl] trimethylammonium chloride to an experimental adhesiveAbstract: The aim of this study was to develop an experimental adhesive with addition of [2-(methacryloyloxy)ethyl]trimethylammonium chloride (METAC) and to evaluate its mechanical and biological properties and its in vitro antibacterial activity. An experimental adhesive resin was formulated with Bis-GMA, TEGDMA, and HEMA. The antibacterial monomer was added at concentrations of 1%, 2.5%, and 5% (METAC groups). A group without METAC addition was used as control. The experimental adhesives were evaluated as to their antibacterial potential against Streptococcus mutans, degree of conversion, and softening in ethanol for 2 hours. The data were analyzed by one-way ANOVA, Tukey's post-hoc test, and the paired Student's t-test (significance level of 0.05). METAC showed antibacterial activity against S. mutans at all concentrations (p < 0.05). There was no statistical difference across METAC groups (p > 0.05). The 1%, 2.5%, and 5% groups yielded the highest mean values for degree of conversion (p < 0.05). The 1% group did not differ from the control group (p > 0.05). There was no statistical difference in baseline microhardness values (p > 0.05) and microhardness values after immersion in ethanol were lower than at baseline for all groups (p < 0.05). There was no statistical difference in the reduction of Knoop hardness number (KHN) after immersion in ethanol for any of the groups (p > 0.05). The results of the present study indicate that METAC is a promising antibacterial agent when added to an adhesive system.

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An in vivo evaluation of bonding ability of comprehensive antibacterial adhesive system incorporating MDPB

Cited by 120 publications

References 16 publications

Antibacterial effects of three experimental quaternary ammonium salt (QAS) monomers on bacteria associated with oral infections

Antibacterial effects of three experimental quaternary ammonium salt (QAS) monomers on bacteria associated with oral infections

Assessment of bactericidal effects of quaternary ammonium-based antibacterial monomers in combination with colloidal platinum nanoparticles

Influence of addition of [2-(methacryloyloxy)ethyl]trimethylammonium chloride to an experimental adhesive

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