An In Vivo Accelerated Developmental Myelination Model for Testing Promyelinating Therapeutics

Abstract

of NeuroScience Associates for preparing the stained MBP sections, performing quantitative image analysis and facilitating the use of this staining technique in this study. In addition, we thank Rob Donoho from Sword Diagnostics for guidance using resonance Raman spectroscopy to enhance ELISA sensitivity. We thank Pippa Loupe, Simon Tout, Jessica Alexander and Aric Orbach at Teva Pharmaceuticals for critically reviewing the manuscript. We are also grateful to Elen Rosler who shared the unpublished pilot study results of which made this model possible. Finally we are profoundly grateful to the late Dr. Ben Barres for his unending scientific support through the years at the Myelin Repair Foundation and at Teva R&D-particularly for his discovery of the novel role of thyroid hormone in controlling the timing of oligodendrocyte differentiation in development-the basis of our in vitro screening assays and the original concept of this in vivo model.