An in vitro release study of 5-fluoro-uracil (5-FU) from swellable poly-(2-hydroxyethyl methacrylate) (PHEMA) nanoparticles

Abstract

Nanomaterials are at the leading edge of the rapidly developing field of nanotechnology. The use of nanoparticles as drug delivery vehicles for anticancer therapeutics has great potential to revolutionize the future of cancer therapy. The present paper concerns both the optimizations of anticancer drug loading and its release from polymeric nanoparticles. The major aim of this study was to design poly (HEMA) nanoparticles as swelling controlled drug release system for anticancer drug. The prepared nanoparticles were characterized by Infra-Red (IR) Spectra, Particle size Analysis, and Scanning Electron Microscopy (SEM). The nanoparticles were loaded with widely used anticancer drug, 5-Fluorouracil, and controlled release of drug was investigated to observe the effects of various parameters such as percent loading of the drug, chemical architecture of the nanocarriers, pH, temperature, and nature of release media on the release profiles. The chemical stability of 5-Fluorouracil (5-FU) was also tested in phosphate buffer saline (PBS) (pH = 7.4) and release was studied in various simulated biological fluids. The prepared nanoparticles could provide a possible pathway for controlled and targeted delivery of anticancer drug, thus causing lower side effects and higher efficacy.

Nanocrystalline hydroxyapatite and zinc-doped hydroxyapatite as carrier material for controlled delivery of ciprofloxacin

“…It proved moderately effective in killing both gram-positive and gram-negative bacteria (Norris et al 2005). Ultrasonically controlled release of ciprofloxacin is also achieved by pHEMA hydrogels (Chouhan and Bajpal 2009). Poly-(2-hydroxyethyl methacrylate) is used for the delivery of 5-fluro-uracil (Vijayakumar and Jain 2007).…”

Optimizing the Process Parameters for Encapsulation of Linamarin into PLGA Nanoparticles Using Double Emulsion Solvent Evaporation Technique

“…1−3 Targeting cancer cells is a major goal for most researchers who aim to convey a sufficient and controlled dose of drug to the tumor. 4 Linamarin (Fig. 1), a cyanogenic glycoside (2-β-D-glucopyranosyloxy-2-methylpropanenitrile), is found in cassava (Manihot esculenta Crantz) root cortex and parenchyma and has good water solubility.…”

Sodium alginate–polyvinyl alcohol–bovin serum albumin coated Fe3O4 nanoparticles as anticancer drug delivery vehicle: Doxorubicin loading and in vitro release study and cytotoxicity to HepG2 and L02 cells

“…The observed increase in the released amount of drug can be clarified by the point that with increasing temperature, the network chains also undergo quicker reduction because of an improved kinetic energy and therefore simplify the water sorption process [81]. The increase in drug release can be credited to the point that on rising temperature the hydrogen bonds between…”