An In Vitro Patient-Specific Biological Model of the Cerebral Artery Reproduced with a Membranous Configuration for Simulating Endovascular Intervention

Abstract

We propose an in vitro patient-specific anatomical model of the human cerebral artery and its simulation of endovascular intervention, a potent treatment modality for cerebrovascular diseases. Our proposed model reproduces the 3-dimensional vasculature lumen, using computed tomography (CT) and magnetic resonance (MR) fluoroscopic information, within a thin artery-like membranous configuration having material properties close to arterial tissue. This cerebral arterial model reproduces an exceedingly realistic surgical feel, dynamic vascular deformation and, other important aspects involving endovascular intervention, realizing a highly realistic surgical simulation. We also propose another vasculature model that reproduces the subarachnoid space around the cerebral arteries. This version simulates endovascular intervention realistically. The model is compatible with current major imaging modalities such as CT, MR, and transcranial Doppler (TDC), and should provide effective platforms for applications, such as diagnosis, surgical planning, medical training, hemodynamic analysis and medical system development and evaluation, especially surgical robots.

The hemodynamic study for growth factor evaluation of rupture cerebral aneurysm followed up for five years

“…To verify the accuracy of the computer fluid dynamics data, experiments were conducted in an in vitro environment using a silicone blood vessel model in membrane configuration; it was constructed using the technique proposed by Ikeda et al [8]. The membrane model was built from 3D geometry data obtained by scanning the cerebral arteries of a patient.…”

Retinal vessel model fabricated on a curved surface structure for a simulation of microcannulation

“…Basically, two types of surgical simulators exist: a computer-based virtual reality (VR) simulator [11][12][13][14][15], and a mock-up simulator made of artificial materials [16][17][18][19][20]. Once electronic data from the target parts are acquired, the VR simulator can construct the target parts with high reproducibility.…”

“…Several studies have already been published discussing mock-up simulators for various sections of blood vessels [17][18][19][20]. For large vessels (in mm) such as the coronary artery or arteries in the brain, such simulators can benefit from 3D printing technology.…”

“…For large vessels (in mm) such as the coronary artery or arteries in the brain, such simulators can benefit from 3D printing technology. To simulate catheterization surgery, Ikeda et al fabricated a millimeter-sized 3D vessel model made of polydimethylsiloxane (PDMS) using the lost-wax method [17,18]. However, fabricating a model of fine vessels of size below 100 μm (e.g., retinal vessels) is difficult with this method.…”

Catheter Insertion Reference Trajectory Construction Method Using Photoelastic Stress Analysis for Quantification ofRespect for TissueDuring Endovascular Surgery Simulation

“…Then merging to softer and transparent materials, models of human vasculature were built from corrosion cast of vascular lumen of diseased human specimen (Gailloud et al 1997). More advanced modeling techniques are based on silicone elastomer, and enable DICOM data fusion, reproduce the human vasculature lumen with 13 mm of accuracy, have an elastic modulus of 2 MPa (human vasculature elastic modulus: 1-3 MPa), and its friction coefficient can be set at 0.042 (Ikeda et al 2005). These simulators offer the advantage that enable to insert any standard intravascular devices into the silicone vasculature, and offer a realistic representation of the interaction between these devices, human blood vessel morphology, and flow circulation.…”