An in vitro model to monitor natural killer cell effector functions against breast cancer cells derived from human tumor tissue

Beelen, Nicky A.; Ehlers, Femke A. I.; Kooreman, Loes; Bos, Gerard M.J.; Wieten, Lotte

doi:10.1016/bs.mcb.2022.05.001

Cited by 1 publication

(1 citation statement)

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“…Natural killer (NK) cells are an important subset of innate immune cells that are found to be essential for tumor immunosurveillance ( 129 ). One study showed that NETs might inhibit the function of NK cells by upregulating LGAS9 and CEACAM1 genes, which are negative regulators for NK cells in patients with COVID-19 ( 130 ).…”

Section: Nets In Immune Cellsmentioning

confidence: 99%

Neutrophil extracellular traps in tumor progression and immunotherapy

Yan

Sun

et al. 2023

Front. Immunol.

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Tumor immunity is a growing field of research that involves immune cells within the tumor microenvironment. Neutrophil extracellular traps (NETs) are neutrophil-derived extracellular web-like chromatin structures that are composed of histones and granule proteins. Initially discovered as the predominant host defense against pathogens, NETs have attracted increasing attention due to they have also been tightly associated with tumor. Excessive NET formation has been linked to increased tumor growth, metastasis, and drug resistance. Moreover, through direct and/or indirect effects on immune cells, an abnormal increase in NETs benefits immune exclusion and inhibits T-cell mediated antitumor immune responses. In this review, we summarize the recent but rapid progress in understanding the pivotal roles of NETs in tumor and anti-tumor immunity, highlighting the most relevant challenges in the field. We believe that NETs may be a promising therapeutic target for tumor immunotherapy.

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Section: Nets In Immune Cellsmentioning

confidence: 99%