An in vitro-in vivo investigation of oral bioadhesive controlled release furosemide formulations

Santus, Giancarlo; Lazzarini, C.; Bottoni, G; Sandefer, Erik P.; Page, Richard C.; Döll, W; Ryo, U. Yun; Digenis, George A.

doi:10.1016/s0939-6411(97)00100-8

Cited by 55 publications

(29 citation statements)

References 14 publications

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“…Therefore different approaches have been proposed to retain the dosage form in the stomach. These include bioadhesive systems (Santus, et al 1997), swelling and expanding systems (Deshpande et al 1996) and floating systems (Menon et al 1994). In some cases, gastro retention is achieved by concomitant administration of drugs or excipientswhich slow the motility of GIT (Moes 1994).…”

Section: Introductionmentioning

confidence: 99%

Cefuroxime axetil loaded gastroretentive floating tabletsbased on hydrophilic polymers: preparation and in vitro evaluation

Mohapatra

KumarKar²,

Mohapatra³

et al. 2012

Braz. arch. biol. technol.

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Section: Introductionmentioning

confidence: 99%

Cefuroxime axetil loaded gastroretentive floating tabletsbased on hydrophilic polymers: preparation and in vitro evaluation

Mohapatra

KumarKar²,

Mohapatra³

et al. 2012

Braz. arch. biol. technol.

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“…Several approaches are currently used to retain the dosage form in the stomach. These include bioadhesive systems [5], swelling and expanding systems [6,7], floating systems [8,9], and other delayed gastric emptying devices [10,11]. The principle of floating preparation offers a simple and practical approach to achieve increased gastric residence time for the dosage form and sustained drug release.…”

Section: Introductionmentioning

confidence: 99%

Microencapsulation of Verapamil Hydrochloride: A Novel Approach for Gastric Retention Using Different Polymers

P¹,

Patel²,

R³

2012

Med Chem

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The aim of the present investigation was to prepare and evaluate gastroretentive floating microspheres of Verapamil hydrochloride that would retain the drug in stomach and continuously release the drug in controlled manner up to a predetermined time. Floating microspheres were prepared by emulsion solvent evaporation technique. In the present investigation three polymers were used in various concentrations; Methocel K4M, Methocel K15M and Methocel K100M. In vitro performance was evaluated by the usual pharmacopoeial and other tests such as particle size analysis, drug entrapment efficiency, flow properties, in vitro floatability studies, in vivo floatability studies in dog, in vitro drug release studies, stability studies etc. Results showed that the mixing ratio of components in the organic phase affected the size, size distribution, yield, drug content, floating time and drug release of microspheres. In most cases good in vitro floating behavior was observed and a broad variety of drug release pattern could be achieved by variation of the drug, polymer and solvent ratio.

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“…The suggested adult oral dosage of ranitidine is 150 mg twice daily or 300 mg once daily. The effective treatment of erosive esophagitis requires administration of 150 mg of ranitidine 4 times a day [2]. For the short term symptomatic relief of heartburn or non-ulcer dyspepsia a dose of 120 mg up to twice daily is suggested [3].…”

Section: Introductionmentioning

confidence: 99%

An Emerging Trend in Tablet Technology:- Floating Tablets of Ranitidine HCl .

Khemariya¹,

Mishra²,

Shukla³

et al. 2010

Int j Drug delivery

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The rationale of this research was to prepare a gastroretentive drug delivery system of Ranitidine HCL. Floating Drug delivery system used to target drug release in the stomach or to the upper part of the intestine. The oral delivery of Ranitidine is tested by preparing a non-disintegrating floating dosage form, which increase its absorption in the stomach by increasing the drug's gastric residence time. The polymer PVC and Sodium bicarbonate was used as the gas-generating agents. Sodium bicarbonate causes the tablets to floats for more then 24hr. The prepared tablets were evaluated on their physicochemical properties and drug release characters. In-vitro release studies indicate that the Ranitidine release form the floating dosage form was uniform followed zero order release. A combination of sodium bicarbonate (70mg) and citric acid (15mg) was found to achieve Optimum in vitro buoyancy. The tablets with methocel K100 were found to float for longer duration of time as compared to formulations containing methocel K15M. The drug release from the tablets was sufficiently sustained.

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An in vitro-in vivo investigation of oral bioadhesive controlled release furosemide formulations

Cited by 55 publications

References 14 publications

Cefuroxime axetil loaded gastroretentive floating tabletsbased on hydrophilic polymers: preparation and in vitro evaluation

Cefuroxime axetil loaded gastroretentive floating tabletsbased on hydrophilic polymers: preparation and in vitro evaluation

Microencapsulation of Verapamil Hydrochloride: A Novel Approach for Gastric Retention Using Different Polymers

An Emerging Trend in Tablet Technology:- Floating Tablets of Ranitidine HCl .

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