“…It was demonstrated that GI environment and transit time have a strong impact on in vivo dissolution and exposure of itraconazole, a class II drug (Abuhelwa, Mudge, Hayes, Upton, & Foster, ). It was disclosed that biorelevant dissolution media are important for anticipating the in vivo response of products co‐administered with aqueous and nonaqueous vehicle (Mercuri, Fares, Bresciani, & Fotaki, ). Model validation and percent predictability error (%PE) estimated for C max and AUC were held within the acceptable range (<10%) of FDA guidelines and thus proving the predictability of level A correlation for quetiapine, lidocaine, and divalproex (De Lima & De Campos, 2016; Dutta, Qiu, Samara, Cao, & Granneman, ; Kondamudi, Tirumalasetty, Malayandi, Mutalik, & Pillai, ).…”