An in vitro evaluation of antimicrobial activity of a fast-setting endodontic material

Ji, Mengzhen; Chi, Yaqi; Wang, Ye; Xiong, Kaixin; Chen, Xuan; Zou, Ling

doi:10.1038/s41598-022-20454-7

Cited by 8 publications

(5 citation statements)

References 29 publications

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“…Our results agree with a previous study 40 , which found no bacterial inhibition zones around Biodentine against E. faecalis in the agar diffusion test. However, the direct contact method detected antibacterial activity against the same bacteria, confirming the influence of the in vitro testing method on antibacterial results for the same bacterial strain and cement.…”

Section: Asdj Ain Shams Dental Journalsupporting

confidence: 93%

“…While many direct contact test studies have found several dental materials effective against planktonic cultured bacteria, they could not show their effectiveness against biofilm microorganisms and infected dentine. 40,41 Fluoride-releasing dental materials are assumed to be effective in caries control, this assumption is still contraversial. 10 The combined antibacterial and fluoride release qualities with its remineralization potential added to Biodentine may improve its clinical performance, especially in the recent conservative techniques that recommend incomplete caries removal, leading to increased bacterial load and remaining infected dentine.…”

Section: Asdj Ain Shams Dental Journalmentioning

confidence: 99%

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Antibacterial behavior of calcium fluoride-modified tricalcium silicate cement against different oral bacterial strains

Elbanna,

Elmesellawy,

El-Refai

2024

Ain Shams Dental Journal

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Aim: This study aimed to evaluate the effect of adding CaF2 to Biodentine on its antibacterial behavior against Streptococcus mutans, Lactobacillus acidophilus, and Enterococcus faecalis strains and the fluoride release. Materials and methods:The study included three main groups: unmodified Biodentine, 5% wt CaF2-modified Biodentine, and 10% wt CaF2-modified Biodentine. The antibacterial activity of the tested cement was evaluated against the three bacterial strains through direct contact and agar diffusion tests. Fluoride release in deionized water at different intervals (1 day, one week, and one month) was assessed using ICP-MS. Results: The direct contact test revealed that the different experimental biodentine groups had lower optical density than the bacteria groups after one day, which was confirmed at seven days. The 10% group showed a significantly higher antibacterial effect against S. mutans and L. acidophilus than the other biodentine groups. The agar diffusion test showed significant differences between groups regarding Streptococcus mutans and Lactobacillus acidophilus. The positive control group had significantly higher inhibition zone values than the 5% CaF2-modified and unmodified Biodentine groups. The 10% CaF2-modified group showed no statistically significant difference compared to the positive control. For Enterococcus faecalis, the positive control exhibited a significantly higher value than other groups. None of the experimental groups showed inhibition zones against Enterococcus faecalis. Conclusions: Adding 10% CaF2 to Biodentine could improve its antibacterial effect against S. mutans and L. acidophilus. However, its effectiveness against Enterococcus faecalis is questionable. The addition of 10% CaF2 also offers fluoridereleasing qualities to Biodentine.

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Section: Asdj Ain Shams Dental Journalsupporting

confidence: 93%

Section: Asdj Ain Shams Dental Journalmentioning

confidence: 99%

Antibacterial behavior of calcium fluoride-modified tricalcium silicate cement against different oral bacterial strains

Elbanna,

Elmesellawy,

El-Refai

2024

Ain Shams Dental Journal

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“…However others found no statistically significant difference in antifungal efficacy for C. albicans between ProRoot MTA, and Biodentine [53] . In contrast, other authors found no difference in antibacterial activity against E. faecalis between them [52,54,55] .…”

Section: Methodsmentioning

confidence: 80%

Antibacterial Potential of Pulp Capping Materials

Dimitrova

2024

non-met. mater. sci.

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A critical analysis of the antibacterial effect of the main representatives of calcium silicate cements (CSCs) was made. An analysis of the most frequently used methods for screening the antibacterial activity of materials has been made. The inhibitory activity of CSCs against major types of microorganisms such as Candia albicans, E. faecalis, and strains streptococcus was evaluated and compared. The antibacterial effects of CSCs are not yet well and completely known because no evidence compares the antibacterial properties of bioceramic materials with a uniform methodological approach. It is important to provide standardization of testing methods for evaluating the antibacterial potential of the materials and different bacterial strains. To this stage, there are no reproducible and standardized methods for evaluating of antibacterial activity of CSCs.

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“…MTA has been shown to possess antibacterial activity against various microorganisms commonly found in dental infections, including E. faecalis , Streptococcus mutans , and S. aureus . [ 21 ]…”

Section: Discussionmentioning

confidence: 99%

Comparative evaluation of the antimicrobial activity of NeoPutty MTA and modified NeoPutty MTA: An in vitro study

Acharya,

Gurunathan,

Sahoo

et al. 2023

JISPCD

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Aim: Mineral trioxide aggregate (MTA) is a relatively new versatile dental material. MTA has many advantages as well as disadvantages. To reduce most of the drawbacks of MTA, a premixed bioceramic MTA, NeoPutty MTA, was introduced in 2020. In this study, we assessed the antimicrobial activity of the newer MTA, NeoPutty MTA. We modified NeoPutty MTA and compared both against Enterococcus faecalis, Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. Materials and Methods: Using the agar diffusion method, NeoPutty MTA was tested for antibacterial activity against the above-mentioned microorganisms. A base layer of Petri plates was done using Muller–Hinton agar for S. aureus, E. coli, and P. aeruginosa and brain heart infusion agar for E. faecalis. A total of 32 plates were employed; the plates were divided randomly into four test groups having eight plates each, so microorganisms were tested eight times. Three cavities were made in agar and filled with freshly mixed materials after 24 h. A pour plate seeded the microorganisms. The plates were pre-incubated for 2 h at room temperature and incubated at 37°C for 24 h. An independent observer measured the inhibition zone diameters. Results: NeoPutty MTA, when tested alone, did not show much antibacterial activity against E. faecalis, S. aureus, and E. coli but had significant antimicrobial activity against P. aeruginosa when used at different concentrations. Modified NeoPutty (NeoPutty with antibiotics added individually) showed significant antibacterial activity against these microorganisms, as seen by the zone of inhibition of these bacteria. Conclusion: Modified NeoPutty with antibiotics has a better antimicrobial effect than NeoPutty MTA.

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An in vitro evaluation of antimicrobial activity of a fast-setting endodontic material

Cited by 8 publications

References 29 publications

Antibacterial behavior of calcium fluoride-modified tricalcium silicate cement against different oral bacterial strains

Antibacterial behavior of calcium fluoride-modified tricalcium silicate cement against different oral bacterial strains

Antibacterial Potential of Pulp Capping Materials

Comparative evaluation of the antimicrobial activity of NeoPutty MTA and modified NeoPutty MTA: An in vitro study

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