An in vitro comparison of effect on fracture strength, pH and calcium ion diffusion from various biomimetic materials when used for repair of simulated root resorption defects

Abstract

Aim:The aim of this study was to compare the effect on fracture strength, pH and calcium ion diffusion from mineral trioxide aggregate (MTA) Fillapex, iRoot SP, and Ultracal when used for repair of simulated root resorption defects.Materials and Methods:Three sets of 40 teeth each were used, and biomechanical preparation was done. Resorption cavity was made at 5 mm from the apex. Teeth were filled with different experimental materials. In control group, saline was used. Samples of fracture resistance were stored in an incubator for 3 months and then subjected to the universal testing machine. To evaluate the pH and calcium ion release were checked at 1 day and 1, 2, 3, and 4 weeks intervals. Data were recorded and statistical analysis done by one-way analysis of variance followed by post-hoc Tukey test.Results:Highest fracture resistance was seen in MTA Fillapex followed by iRoot SP, control, and then Ultracal group. Teeth filled with iRoot SP showed highest pH and calcium ion release followed by MTA Fillapex and Ultracal group.Conclusion:Bioceramic sealers showed high pH, calcium ion release, and good root reinforcement potential. Initial dressing of calcium hydroxide followed by obturation with Gutta-percha and bioceramic sealer may be considered as an alternative treatment modality for inflammatory resorption.

In Vivo Comparative Evaluation of Periapical Healing in Response to a Calcium Silicate and Calcium Hydroxide Based Endodontic Sealers

“…Diffusion of calcium and hydroxyl ions from a material depends on such characteristics. Such finding is in agreement with Chetna Dudeja et al, [ 23 ], where teeth filled with iRoot SP showed higher pH and calcium ion release when compared with a calcium hydroxide based sealer (Ultracal).…”

Composition and physicochemical properties of calcium silicate based sealers: A review article

“…EndoSequence BC Sealer has also been shown to have high pH (>11) ( 38 ). iRoot SP showed more pH value than MTA Fillapex ( 52 ).…”

“…Calcium release of MTA Fillapex was superior than guttaflow ( 50 ) and inferior than iRoot SP ( 52 ). EndoSequence BC Sealer had high tendency to release calcium ions than AH plus sealer ( 38 ).…”

“…Dudeja stated that initial dressing of calcium hydroxide followed by obturation with Gutta-percha and iRootSP and MTA Fillapex sealers may be considered as an alternative treatment modality for inflammatory resorption and it is beneficial when compared to the long-term calcium hydroxide application ( 52 ). The reason for this phenomenon is calcium ion release performed by bioceramic sealers.…”

The emerging role of extracellular Ca2+ in osteo/odontogenic differentiation and the involvement of intracellular Ca2+ signaling: From osteoblastic cells to dental pulp cells and odontoblasts

“…Li, Cao, Fan, & Xu, 2015). These improvements may be, in part, due to osteo/odontogenic differentiation of human DPCs induced by the higher levels of Ca 2+ released from MTA (Dudeja, Kumari, Singh, & Taneja, 2015) and mobilization of Ca 2+ , silicon, and strontium ions via the activation of Ca 2+ channels (e.g., CaSR) and MAPK pathways (J. M. Kim et al, 2017;Mizumachi et al, 2017;Wu et al, 2014). Furthermore, H. Zhang, Shen, Ruse, and Haapasalo (2009) over a 28-day period at pH 7.0, while at pH 5.5 these levels dropped significantly, by 24%, after 21 days (Natale et al, 2015).…”