An In Vitro and In Vivo Investigation of the Antimetastatic Effects of a Chinese Medicinal Decoction, Erxian Decoction, on Human Ovarian Cancer Models

Chu, Ellie S.M.; Sze, Stephen Cho Wing; Cheung, Ho Pan; Liu, Qing; Ng, Tzi Bun; Tong, Yao

doi:10.1177/1534735412464519

Cited by 13 publications

(7 citation statements)

References 42 publications

(47 reference statements)

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“…While a previous study showed EXD to have anti-inflammatory activity [ 34 ], the present study suggested the pathways to include the Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, and Fc epsilon RI signaling pathway [ 70 – 72 ]. This findings were consistent with previous studies on EXD antimetastatic activity in a human ovarian cancer model [ 73 ] and its antiangiogenic properties [ 61 ].…”

Section: Discussionsupporting

confidence: 93%

Network pharmacological identification of active compounds and potential actions of Erxian decoction in alleviating menopause-related symptoms

Wang

Tong

et al. 2015

Chin Med

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BackgroundErxian decoction (EXD) is used to treat menopause-related symptoms in Chinese medicine. This study aims to identify the bioactive compounds and potential actions of EXD by network pharmacological analysis.MethodsTwo databases, the Traditional Chinese Medicine Systems Pharmacology database and TCM Database@Taiwan, were used to retrieve literature of phytochemicals of EXD. STITCH 4.0 and the Comparative Toxicogenomics Database were used to search for compound–protein and compound–gene interactions, respectively. DAVID Bioinformatics Resources 6.7 and Cytoscape 3.01 with Jepetto plugin software were used to perform a network pharmacological analysis of EXD.ResultsA total of 721 compounds were identified in EXD, of which 155 exhibited 2,656 compound–protein interactions with 1,963 associated proteins determined by STITCH4.0 database, and of which 210 had 14,893 compound–gene interactions with 8,536 associated genes determined by Comparative Toxicogenomics Database. Sixty three compounds of EXD followed the Lipinski’s Rule with OB ≥30% and DL index ≥0.18, of which 20 related to 34 significant pathway- or 12 gene- associated with menopause.ConclusionsTwenty compounds were identified by network pharmacology as potential effective ingredients of EXD for relieving menopause with acceptable oral bioavailability and druggability.Electronic supplementary materialThe online version of this article (doi:10.1186/s13020-015-0051-z) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 93%

Network pharmacological identification of active compounds and potential actions of Erxian decoction in alleviating menopause-related symptoms

Wang

Tong

et al. 2015

Chin Med

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“…For centuries, PAC has been utilized solely or in combination with other medicines for the clinical treatment of various diseases, and used to produce drugs such as Huangbai capsule, Zhi-bai-di-huang pills, Huang-lian-jie-du decoction, Er-miao pills, Er-xian decoction, Si-miao pills, etc. [8,9,10,11].…”

Section: Introductionmentioning

confidence: 99%

A New Method for Simultaneous Determination of Phenolic Acids, Alkaloids and Limonoids in Phellodendri Amurensis Cortex

et al. 2019

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Phellodendri Amurensis Cortex (PAC) is a well-known herbal medicine in China with complex components, but the previous research has mostly focused on its alkaloids analysis. For the first time, a simpler and more efficient method was proposed in this paper to simultaneously determine the content of three different kinds of compounds—phenolic acids, alkaloids and limonoids—in PAC. The phenolic acids included 3-O-feruloylquinic acid, 4-O-feruloylquinic acid and syringin. The alkaloids include magnoflorine, phellodendrine, jatrorrhizine, palmatine and berberine, while the limonoids include obaculactone and obacunone. An approach combining multi-wavelength and HPLC-DAD was used in this study due to the great difference in maximum absorption wavelength of the various components. Four wavelengths at 215, 275, 280 and 310 nm, respectively, were chosen for monitoring. It has been indicated through appropriate tests that this approach is of high accuracy, good repeatability and stability and provides a scientific basis for the quality assessment of PAC and associated derivatives. In addition, the chromatographic fingerprints method combined with multivariate statistical analysis chosen in this study was proved to be effective and reasonable for an accurate classification of 33 batches of samples collected from different locations.

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“…Detailed knowledge of the pharmacological effects of combinations of phytochemicals, however, is limited. There is a large literature on herbal combinations used in traditional Chinese medicine in both the laboratory and clinic [61–63], but the quality of older clinical trials is generally low. Additionally, laboratory studies of herbal medicines often use concentrations far higher than are clinically achievable.…”

Section: Methodsmentioning

confidence: 99%

Designing a broad-spectrum integrative approach for cancer prevention and treatment

Block

Gyllenhaal

Lowe

et al. 2015

Seminars in Cancer Biology

238

191

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Targeted therapies and the consequent adoption of “personalized” oncology have achieved notable successes in some cancers; however, significant problems remain with this approach. Many targeted therapies are highly toxic, costs are extremely high, and most patients experience relapse after a few disease-free months. Relapses arise from genetic heterogeneity in tumors, which harbor therapy-resistant immortalized cells that have adopted alternate and compensatory pathways (i.e., pathways that are not reliant upon the same mechanisms as those which have been targeted). To address these limitations, an international task force of 180 scientists was assembled to explore the concept of a low-toxicity “broad-spectrum” therapeutic approach that could simultaneously target many key pathways and mechanisms. Using cancer hallmark phenotypes and the tumor microenvironment to account for the various aspects of relevant cancer biology, interdisciplinary teams reviewed each hallmark area and nominated a wide range of high-priority targets (74 in total) that could be modified to improve patient outcomes. For these targets, corresponding low-toxicity therapeutic approaches were then suggested; many of which were phytochemicals. Proposed actions on each target and all of the approaches were further reviewed for known effects on other hallmark areas and the tumor microenvironment. Potential contrary or procarcinogenic effects were found for 3.9% of the relationships between targets and hallmarks, and mixed evidence of complementary and contrary relationships was found for 7.1%. Approximately 67% of the relationships revealed potentially complementary effects, and the remainder had no known relationship. Among the approaches, 1.1% had contrary, 2.8% had mixed and 62.1% had complementary relationships. These results suggest that a broad-spectrum approach should be feasible from a safety standpoint. This novel approach has potential to help us address disease relapse, which is a substantial and longstanding problem, so a proposed agenda for future research is offered.

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An In Vitro and In Vivo Investigation of the Antimetastatic Effects of a Chinese Medicinal Decoction, Erxian Decoction, on Human Ovarian Cancer Models

Cited by 13 publications

References 42 publications

Network pharmacological identification of active compounds and potential actions of Erxian decoction in alleviating menopause-related symptoms

Network pharmacological identification of active compounds and potential actions of Erxian decoction in alleviating menopause-related symptoms

A New Method for Simultaneous Determination of Phenolic Acids, Alkaloids and Limonoids in Phellodendri Amurensis Cortex

Designing a broad-spectrum integrative approach for cancer prevention and treatment

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