An in vitro and in silico approach to cholinesterase inhibitory and antioxidant effects of the methanol extract, furanocoumarin fraction, and major coumarins of Angelica officinalis L. fruits

Şenol, Fatma Sezer; Skalicka-Woźniak, Krystyna; Khan, Mahmud Tareq Hassan; Orhan, İlkay Erdoğan; Şener, Bilge; Głowniak, Kazimierz

doi:10.1016/j.phytol.2011.08.016

Cited by 67 publications

(56 citation statements)

References 26 publications

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“…For instance, some coumarins are shown to have a strong impact on the central nervous system, acting as anxiolytics or acetylcholinesterase inhibitors (Budzyń ska et al, 2013;Senol et al, 2011). Psoralen, when activated by UVA radiation, interferes with DNA and cellular replication, and thus can be used in disorders associated with increased cell division (psoriasis) or induction of pigmentation (vitiligo) as PUVA therapy (Conforti et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Bioactivity-guided isolation of antimicrobial coumarins from Heracleum mantegazzianum Sommier & Levier (Apiaceae) fruits by high-performance counter-current chromatography

et al. 2015

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Section: Introductionmentioning

confidence: 99%

Bioactivity-guided isolation of antimicrobial coumarins from Heracleum mantegazzianum Sommier & Levier (Apiaceae) fruits by high-performance counter-current chromatography

et al. 2015

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“…At present, cholinesterase inhibitors are one of the most prescribed drug classes for AD treatment (Senol et al 2011); however, these drugs cause many side effects (Dunn et al 2000;Alfirevic et al 2007). In consequence, finding new sources for the safest and most effective drugs against this disease becomes relevant.…”

Section: Discussionmentioning

confidence: 99%

“…AD is a progressive disease leading to the degeneration of cholinergic neurons, loss of cholinergic neurotransmission, and the formation of abnormal aggregates of bamyloid (Ab) protein fragments throughout the brain (Senol et al 2011). Although neuronal loss is the main neuropathologic feature underlying the symptoms of AD, the accumulation of Ab may initiate the inflammatory process , as well as the production of reactive oxygen species (ROS) and oxidative injury (Wollen 2010).…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory, antioxidant and anti-acetylcholinesterase activities of Bouvardia ternifolia: potential implications in Alzheimer’s disease

et al. 2015

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Bouvardia ternifolia has been used medicinally to treat inflammation. In the present study, we investigate the anti-Alzheimer's potential effect of the hydroalcoholic extract of B. ternifolia through evaluation of anti-inflammatory and antioxidant activities, quantification of the percentage inhibition of acetylcholinesterase activity, protection effect against β-amyloid fibrillar-induce neurotoxicity, and the identification of the main constituents. Our results show that B. ternifolia extract and ethyl acetate fraction induced anti-inflammatory effects by reducing inflammation by >70 %, while antioxidant test revealed significant IC50 values for flavonoid content fraction (30.67 ± 2.09 μg/ml) and ethyl acetate fraction (42.66 ± 0.93 μg/ml). The maximum inhibition of acetylcholinesterase was exhibited by scopoletin content fraction (38.43 ± 3.94 %), while ethyl acetate fraction exerted neuroprotective effect against β-amyloid peptide (83.97 ± 5.03 %). Phytochemical analysis, showed the presence of 3-O-quercetin glucopyranoside (415 mg/g), rutin (229.9 mg/g), ursolic and oleanolic acid (54 and 20.8 mg/g respectively), 3-O-quercetin rhamnopyranoside (12.8 mg/g), chlorogenic acid (9.5 mg/g), and scopoletin (1.38 mg/g). Our findings support the use of B. ternifolia since the extract induced significant neuroprotection against β-amyloid peptide, anti-inflammatory, antioxidant and anti-acetylcholinesterase effects that could be attributed to its contents of polyphenols, coumarins, and triterpenes, and encourage further studies for development of this extract as therapeutic agent in treatment of Alzheimer's disease.

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“…Imperatorin was isolated from the fruits of Angelica archangelica (Hofm) by column chromatography [39]. Imperatorin at final concentrations of 50 μM, 100 μM, 150 μM, and 200 μM, and cisplatin (Sigma) at final concentrations of 2 μM, and 5 μM were used in the experiments.…”

Section: Methodsmentioning

confidence: 99%

Cell death in HeLa cells upon imperatorin and cisplatin treatment

Jakubowicz-Gil¹,

Paduch²,

Ulz³

et al. 2012

Folia Histochem Cytobiol.

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Abstract:There is growing evidence that commonly applied chemotherapy regimens can be improved by introducing new, specific, active and low side-effect drugs, or by combining substances to obtain the required clinical effect. The aim of the present study was to investigate the effects of imperatorin and cisplatin, applied separately or in combination, on apoptosis, necrosis and autophagy induction in the human cervical carcinoma cell line (HeLa). Imperatorin appeared to be a potent autophagy inducer, rather than a necrotic or apoptotic one. In contrast, cisplatin induced mainly apoptosis and necrosis after 6 h and 24 h, while longer incubation resulted only in necrosis induction. When HeLa cells were incubated with both drugs, autophagy appeared most frequently, although to a smaller extent than that observed after imperatorin administered alone. At the molecular level, autophagy was correlated with the presence of the cleaved form of microtubule-associated protein 1 light chain LC3 -LC3II. It was also accompanied by the inhibition of heat shock proteins Hsp27 and Hsp72 expression. Our results indicate that imperatorin alone, or in combination with cisplatin, is mainly an autopahgy

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An in vitro and in silico approach to cholinesterase inhibitory and antioxidant effects of the methanol extract, furanocoumarin fraction, and major coumarins of Angelica officinalis L. fruits

Cited by 67 publications

References 26 publications

Bioactivity-guided isolation of antimicrobial coumarins from Heracleum mantegazzianum Sommier & Levier (Apiaceae) fruits by high-performance counter-current chromatography

Bioactivity-guided isolation of antimicrobial coumarins from Heracleum mantegazzianum Sommier & Levier (Apiaceae) fruits by high-performance counter-current chromatography

Anti-inflammatory, antioxidant and anti-acetylcholinesterase activities of Bouvardia ternifolia: potential implications in Alzheimer’s disease

Cell death in HeLa cells upon imperatorin and cisplatin treatment

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