An In situ Forming Hydrogel Based on Photo-Induced Hydrogen Bonding

Zhang, Jingyan; Wang, Shifeng; Zhao, Zeren; Si, Dong; Zhou, Haijun; Yang, Ming‐Chang

doi:10.1007/s13233-020-8153-6

Cited by 8 publications

(10 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Consequently, PNIPAm-PAm block copolymers with thiocarbonylthio end groups were obtained. The key for synthesizing architecturally diverse polymers via the approach lies in the retention of the thiocarbonylthio polymer chain end throughout the polymerization. , The PET-RAFT polymerization process is gentle and without intense exothermic, so there is no need for cooling during the synthesis of PNIPAm. ,,,, On the other hand, PET-RAFT polymerization enabled temporal/spatial control over the polymerization process. , Thus, the polymerization process can be started or stopped by turning the light source on or off during hydrogel preparation. This is particularly important in dealing with the interface between hydrogel layers, where the temporal/spatial control can allow continued growth of the second layer directly upon the first layer.…”

Section: Resultsmentioning

confidence: 99%

“…40,41 The PET-RAFT polymerization process is gentle and without intense exothermic, so there is no need for cooling during the synthesis of PNIPAm. 22,28,29,42,43 On the other hand, PET-RAFT polymerization enabled temporal/spatial control over the polymerization process. 21,44 Thus, the polymerization process can be started or stopped by turning the light source on or off during hydrogel preparation.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Versatile Bilayer Hydrogel for Wound Dressing through PET-RAFT Polymerization

et al. 2022

View full text Add to dashboard Cite

Multifunctional hydrogel-based wound dressings have been explored for decades due to their huge potential in multifaceted medical intervention to wound healing. However, it is usually not easy to fabricate a single hydrogel with all of the desirable functions at one time. Herein, a bilayer model with an outer layer for hydrogel wound dressing was proposed. The inner layer (Hm-PNn) was a hybrid hydrogel prepared by N-isopropylacrylamide and chitosan-N-2-hydroxypropyl trimethylammonium chloride (HACC), and the outer layer (PVAo-PAmp) was prepared by polyvinyl alcohols and acrylamide. The two hydrogel layers of the bilayer model were covalently connected with excellent interfacial strength by photoinduced electron/energy transfer-reversible addition-fragmentation chain transfer (PET-RAFT) polymerization. The outer layer exposed to the ambient environment exhibited good stretchability and toughness, while the inner-layer hydrogel adhered to the skin exhibited excellent softness, antibacterial activity, thermoresponsivity, and biocompatibility. In particular, the inner layer of a hydrogel demonstrated excellent antibacterial capability toward both Staphylococcus aureus as Gram-positive bacteria and Escherichia coli as Gram-negative bacteria. Cell cytotoxicity showed that the cell viability of all Hm-PNn layer hydrogels exceeds 80%, confirming that the hydrogels bear excellent biocompatibility. In vivo experimental results indicated that the Hm-PNn/PVAo-PAmp bilayer hydrogel has a significant effect on the acceleration of wound healing, which was demonstrated in a full-thickness skin defect model showing improved collagen disposition and granulation tissue thickness. With these results, the established multifunctional bilayer hydrogel exhibits potential as an excellent wound dressing for wound healing applications, especially for open and infected traumas.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Versatile Bilayer Hydrogel for Wound Dressing through PET-RAFT Polymerization

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Electrospray ionization mass spectrometry (ESI-MS) analysis incorporated with high performance liquid chromatography (HPLC) measurements well confirmed the photocleavability of the released o-NB group accompanied by the production of a nitroso moiety. 61,62 With 30 mW/cm 2 LED light irradiation, the absorbance intensity of the GelMA-NBNAGA solution nearly stabilized in about 1 min, indicating that the photoinduced reaction had almost accomplished, which was much faster than ∼20 min under 1.2 mW/cm 2 LED light irradiation discussed before. 62 So, in the following discussion, 3 min irradiation-induced GelMA-NBNAGA hydrogels were chosen for performance tests.…”

Section: Dn (%)mentioning

confidence: 73%

“…60 In our previous reports, it was successfully utilized as a pendant hydrophobic group of NAGA to shield the strong dual-hydrogen bonding effect of the hydrophilic dual-amide motifs, named, N′-(2-nitrobenzyl)-N-acryloyl glycinamide (NBNAGA). 61,62 Under 365 nm irradiation, the o-NB groups on side chains were released, accompanied by nitroso side products. The "uncaged" dual-amide motifs with excellent hydrophilicity, therefore, constituted the inter-or intrachain dual-hydrogen bonds besides some single hydrogen bonds, which greatly reinforced the H-bonding among side chains (Scheme 1).…”

Section: Introductionmentioning

confidence: 99%

One-Step Physical and Chemical Dual-Reinforcement with Hydrophobic Drug Delivery in Gelatin Hydrogels for Antibacterial Wound Healing

An,

Wang,

Ning

et al. 2024

ACS Omega

Self Cite

View full text Add to dashboard Cite

Gelatin-based bioadhesives, especially methacrylated gelatin (GelMA), have emerged as superior alternatives to sutureless wound closure. Nowadays, their mechanical improvement and therapeutic delivery, particularly for hydrophobic antibiotics, have received ever-increasing interest. Herein, a reinforced gelatin-based hydrogel with a hydrophobic drug delivery property for skin wound treatment was reported. First, photosensitive monomers of N′-(2-nitrobenzyl)-N-acryloyl glycinamide (NBNAGA) were grafted onto GelMA via Michael addition, namely, GelMA-NBNAGA. Second, gelation of the GelMA-NBNAGA solution was accomplished in a few seconds under one step of ultraviolet (UV) light irradiation. Multiple effects were realized simultaneously, including chemical cross-linking initiated by lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP), physical cross-linking of uncaged dual hydrogen bonding, and hydrophobic drug release along with o-NB group disintegration. The mechanical properties of the dual-reinforcement hydrogels were verified to be superior to those only with a chemical or physical single-cross-linked network. The hydrophobic anticancer doxorubicin (DOX) and antibiotic rifampicin (Rif) were successfully charged into the hydrogels, separately. The in vitro antimicrobial tests confirmed the antibacterial activity of the hydrogels against Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacteria. The in vivo wound-healing assessment in mice further assured their drug release and efficacy. Therefore, this NBNAGA-modified GelMA hydrogel has potential as a material in skin wound dressing with a hydrophobic antibiotic on-demand delivery.

show abstract

“…Specifically, injectable conductive hydrogels can be formed after intramyocardial or intrapericardial injection through in situ crosslinking of pre-polymers containing conductive materials based on various reactions, such as photo-crosslinking, click reactions, Schiff base reactions, and Michael reactions. 84 , 85 Wang et al designed an injectable conductive hydrogel via in situ polymerization of tetraaniline-polyethylene glycol (TA-PEG) and thiolated hyaluronic acid (HA-SH) via Michael addition. 86 Adipose-derived stem cells (ADSCs) and lipofectamine nanocomplexes containing plasmid DNA-eNOs (endothelial nitric oxide synthase) were loaded into the gels and subsequently injected into the infarcted heart.…”

Section: Conductive Hydrogels For Cardiac Repairmentioning

confidence: 99%

Nanomaterial-Based Electrically Conductive Hydrogels for Cardiac Tissue Repair

Lee¹,

Kim²,

Lee³

2022

IJN

View full text Add to dashboard Cite

Cardiovascular disease is one of major causes of deaths, and its incidence has gradually increased worldwide. For cardiovascular diseases, several therapeutic approaches, such as drugs, cell-based therapy, and heart transplantation, are currently employed; however, their therapeutic efficacy and/or practical availability are still limited. Recently, biomaterial-based tissue engineering approaches have been recognized as promising for regenerating cardiac function in patients with cardiovascular diseases, including myocardial infarction (MI). In particular, materials mimicking the characteristics of native cardiac tissues can potentially prevent pathological progression and promote cardiac repair of the heart tissues post-MI. The mechanical (softness) and electrical (conductivity) properties of biomaterials as non-biochemical cues can improve the cardiac functions of infarcted hearts by mitigating myocardial cell death and subsequent fibrosis, which often leads to cardiac tissue stiffening and high electrical resistance. Consequently, electrically conductive hydrogels that can provide mechanical strength and augment the electrical activity of the infarcted heart tissue are considered new functional materials capable of mitigating the pathological progression to heart failure and stimulating cardiac regeneration. In this review, we highlight nanomaterial-incorporated hydrogels that can induce cardiac repair after MI. Nanomaterials, including carbon-based nanomaterials and recently discovered two-dimensional nanomaterials, offer great opportunities for developing functional conductive hydrogels owing to their excellent electrical conductivity, large surface area, and ease of modification. We describe recent results using nanomaterial-incorporated conductive hydrogels as cardiac patches and injectable hydrogels for cardiac repair. While further evaluations are required to confirm the therapeutic efficacy and toxicity of these materials, they could potentially be used for the regeneration of other electrically active tissues, such as nerves and muscles.

show abstract

An In situ Forming Hydrogel Based on Photo-Induced Hydrogen Bonding

Cited by 8 publications

References 40 publications

Versatile Bilayer Hydrogel for Wound Dressing through PET-RAFT Polymerization

Versatile Bilayer Hydrogel for Wound Dressing through PET-RAFT Polymerization

One-Step Physical and Chemical Dual-Reinforcement with Hydrophobic Drug Delivery in Gelatin Hydrogels for Antibacterial Wound Healing

Nanomaterial-Based Electrically Conductive Hydrogels for Cardiac Tissue Repair

Contact Info

Product

Resources

About