An in silico structural approach to characterize human and rainbow trout estrogenicity of mycotoxins: Proof of concept study using zearalenone and alternariol

Dellafiora, Luca; Oswald, Isabelle P.; Dorne, Jean‐Lou; Galaverna, Gianni; Battilani, Paola; Dall’Asta, Chiara

doi:10.1016/j.foodchem.2019.126088

Cited by 22 publications

(26 citation statements)

References 48 publications

(55 reference statements)

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“…Also, the low estrogenicity of alternariol in trout has been characterized here for the first time (Dellafiora et al, 2020). Inter-species differences in their toxicokinetic and toxicodynamic may occur depending on evolution of taxa-specific traits.…”

Section: Toxicodynamic: An Example Of An In Silico Structural Approachmentioning

confidence: 73%

Mycotoxin mixtures in food and feed: holistic, innovative, flexible risk assessment modelling approach:

Battilani¹,

Palumbo²,

Giorni³

et al. 2020

EFS3

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Mycotoxins are toxic compounds mainly produced by fungi of the genera Aspergillus, Penicillium and Fusarium. They are present, often as mixtures, in many feed and food commodities including cereals, fruits and vegetables. Their ubiquitous presence represents a major challenge to the health and well being of humans and animals. Hundreds of compounds are listed as possible mycotoxins occurring in raw and processed materials destined for human food and animal feed. In this study, mycotoxins of major toxicological relevance to humans and target animal species were investigated in a range of crops of interest (and their derived products). Extensive Literature Searches (ELSs) were undertaken for data collection on: (i) ecology and interaction with host plants of mycotoxin producing fungi, mycotoxin production, recent developments in mitigation actions of mycotoxins in crop chains (maize, small grains, rice, sorghum, grapes, spices and nuts), (ii) analytical methods for native, modified and co-occurring mycotoxins (iii) toxicity, toxicokinetics, toxicodynamics and biomarkers relevant to humans and animals (poultry, suidae (pig, wild boar), bovidae (sheep, goat, cow, buffalo), rodents (rats, mice) and others (horses, dogs), (iv) modelling approaches and key reference values for exposure, hazard and risk modelling. Comprehensive databases were created using EFSA templates and were stored in the MYCHIF platform. A range of approaches were implemented to explore the modelling of external and internal exposure as well as dose-response of mycotoxins in chicken and pigs. In vitro toxicokinetic and in vivo toxicity databases were exploited, both for single compounds and mixtures. However, large data gaps were identified particularly with regards to absence of common statistical and study designs within the literature and constitute an obstacle for the harmonisation of internal exposure and dose-response modelling. Finally, risk characterisation was also performed for humans as well as for two animal species (i.e. pigs and chicken) using available tools for the modelling of internal dose and a component-based approach for selected mycotoxins mixtures.© European Food Safety Authority, 2020 MYCHIF www.efsa.europa.eu/publications 2 EFSA Supporting publication 2020: EN-1757

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Section: Toxicodynamic: An Example Of An In Silico Structural Approachmentioning

confidence: 73%

Mycotoxin mixtures in food and feed: holistic, innovative, flexible risk assessment modelling approach:

Battilani¹,

Palumbo²,

Giorni³

et al. 2020

EFS3

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“…Acute toxicity with AOH is low, however, genotoxic and oestrogenic effects have been reported in vitro [ 115 ]. In fish, Dellafiora et al [ 116 ] reported low oestrogenic activity of AOH on trout in silico.…”

Section: Discussionmentioning

confidence: 99%

Co-Occurrence and Levels of Mycotoxins in Fish Feeds in Kenya

Mwihia

Lyche

Mbuthia

et al. 2020

Toxins

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This study determined the presence, levels and co-occurrence of mycotoxins in fish feeds in Kenya. Seventy-eight fish feeds and ingredients were sampled from fish farms and fish feed manufacturing plants and analysed for 40 mycotoxins using high-performance liquid chromatography-high resolution mass spectrometry. Twenty-nine (73%) mycotoxins were identified with 76 (97%) samples testing positive for mycotoxins presence. Mycotoxins with the highest prevalences were enniatin B (91%), deoxynivalenol (76%) and fumonisin B1 (54%) while those with the highest maximum levels were sterigmatocystin (<30.5–3517.1 µg/kg); moniliformin (<218.9–2583.4 µg/kg) and ergotamine (<29.3–1895.6 µg/kg). Mycotoxin co-occurrence was observed in 68 (87%) samples. Correlations were observed between the fumonisins; enniatins B and zearalenone and its metabolites. Fish dietary exposure estimates ranged between <0.16 and 43.38 µg/kg body weight per day. This study shows evidence of mycotoxin presence and co-occurrence in fish feeds and feed ingredients in Kenya. Fish exposure to these levels of mycotoxins over a long period of time may lead to adverse health effects due to their possible additive, synergistic or antagonist toxic effects. Measures to reduce fish feed mycotoxin contamination should be taken to avoid mycotoxicosis in fish and subsequently in humans and animals through residues.

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“…The demonstrated properties of ZEN offer the possibility of its practical use, but the application of ZEN on a larger scale should be monitored due to the potential environmental risk (Videmann et al 2008;Gajecka et al 2012;Gao et al 2018;Dellafiora et al 2020). Although zearalenone with toxic properties is present in the environment, it poses a potential risk to animal and human health only if it is absorbed in large quantities or during the long-term exposure (Zinedine et al 2007).…”

Section: Discussionmentioning

confidence: 99%

The Interaction Effect of Drought and Exogenous Application of Zearalenone on the Physiological, Biochemical Parameters and Yield of Legumes

Dziurka

Maksymowicz

Ostrowska

et al. 2020

J Plant Growth Regul

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The effectiveness of exogenously applied zearalenone (ZEN) in alleviating water deficiency stress of pea (Pisum sativum L.) and yellow lupine (Lupinus luteus L.) was analyzed in the pot experiment. ZEN was applied in the form of spraying in the flowering phase on the first day of induced drought. The effectiveness of ZEN was evaluated based on physiological (electrolyte leakage, greenness, and photosystem II activity) and biochemical (protein, proline, ascorbic acid contents, and antioxidant enzyme activity) parameters after 14 days of drought. The yield and yield quality defined as yield components, total protein, fats, sugars, and antioxidants (tocopherols and β-carotene) were measured in newly formed seeds. ZEN residue in the seeds was analyzed employing UHPLC-MS/MS to exclude its accumulation. The results showed the possibility of reducing the effects of drought stress through the use of ZEN. It was manifested by increased cell membranes stability and antioxidant enzyme activity and above all ZEN increased crop yield, compared to untreated plants. ZEN modified seed composition by inducing the accumulation of fats and antioxidants. There was no accumulation of exogenous ZEN in seeds.

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An in silico structural approach to characterize human and rainbow trout estrogenicity of mycotoxins: Proof of concept study using zearalenone and alternariol

Cited by 22 publications

References 48 publications

Mycotoxin mixtures in food and feed: holistic, innovative, flexible risk assessment modelling approach:

Mycotoxin mixtures in food and feed: holistic, innovative, flexible risk assessment modelling approach:

Co-Occurrence and Levels of Mycotoxins in Fish Feeds in Kenya

The Interaction Effect of Drought and Exogenous Application of Zearalenone on the Physiological, Biochemical Parameters and Yield of Legumes

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