2017
DOI: 10.1016/j.exppara.2017.03.005
|View full text |Cite
|
Sign up to set email alerts
|

An in silico functional annotation and screening of potential drug targets derived from Leishmania spp. hypothetical proteins identified by immunoproteomics

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

0
6
0

Year Published

2018
2018
2024
2024

Publication Types

Select...
9

Relationship

1
8

Authors

Journals

citations
Cited by 17 publications
(7 citation statements)
references
References 96 publications
0
6
0
Order By: Relevance
“…Computational analysis in combination with immunoproteomic approaches has led to the screening and identification of new drug targets based on their localization and biological functions [165]. In silico approaches have also been proven to be efficacious in determining the serological significance of leishmanial antigens with tandem repeat domains [166].…”
Section: Modulation Of the Leishmania Proteome Profilementioning
confidence: 99%
See 1 more Smart Citation
“…Computational analysis in combination with immunoproteomic approaches has led to the screening and identification of new drug targets based on their localization and biological functions [165]. In silico approaches have also been proven to be efficacious in determining the serological significance of leishmanial antigens with tandem repeat domains [166].…”
Section: Modulation Of the Leishmania Proteome Profilementioning
confidence: 99%
“…In silico approaches have also been proven to be efficacious in determining the serological significance of leishmanial antigens with tandem repeat domains [166]. A combination of immunoproteomic approaches along with in silico predictions led to the search for new drug targets according to their localization and biological functions [165].…”
Section: Modulation Of the Leishmania Proteome Profilementioning
confidence: 99%
“…In the amastigote extract, four hypothetical and 17 known proteins were identified. From these, virulence factors, such as leucine-rich repeat protein (Mukherjee et al ., 2016), diagnosis markers, such as enolase (Duarte et al ., 2017), vaccine candidates, such as eukaryotic initiation factor 4a (Maspi et al ., 2015), and drug targets, such as calpain-like cysteine peptidase (Chávez-Fumagalli et al ., 2017) were recognized.…”
Section: Resultsmentioning
confidence: 99%
“…In addition, among these candidates, seven were identified as hypothetical proteins [ 17 ]. To predict their subcellular localization and functional annotation, an experimental strategy was employed as described [ 64 ]. Briefly, FASTA sequences of the proteins were retrieved from the UniProt database [ 65 ], and PSORTb 3.0 [ 66 ], PSLpred [ 67 ], CELLO [ 68 ], and WolfPsort [ 69 ] servers were used to predict the subcellular localization of the molecules.…”
Section: Methodsmentioning
confidence: 99%