An improvement of [11C]acetate synthesis—non-radioactive contaminants by irradiation-induced species emanating from the [11C]carbon dioxide production target

Roeda, Dirk; Dolle, Frédéric; Crouzel, C.

doi:10.1016/s0969-8043(02)00224-5

Cited by 32 publications

(21 citation statements)

References 3 publications

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“…HCC was diagnosed according to the criteria of the International Working Party (14). 18 F-FDG and 11 C-Acetate PET/CT 11 C-acetate was synthesized using a fully automated custommade radiochemistry module based on the solid-phase extraction method of Roeda et al (15). 18 F-FDG was synthesized at our hospital using an automated radiochemistry module (Chemical Process Control Unit; CTI/Siemens).…”

Section: Imaging Studies and Biopsymentioning

confidence: 99%

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A Prospective Evaluation of¹⁸F-FDG and¹¹C-Acetate PET/CT for Detection of Primary and Metastatic Hepatocellular Carcinoma

Park¹,

Kim²,

Kim³

et al. 2008

J Nucl Med

252

237

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Because 18 F-FDG PET has insufficient sensitivity for the detection of hepatocellular carcinoma (HCC), 11 C-acetate PET has been proposed as another technique for this use. We prospectively evaluated the value of PET/CT using these 2 tracers for the detection of primary and metastatic HCC. Methods: One hundred twelve patients (99 with HCC, 13 with cholangiocellular carcinoma) underwent biopsy and 18 F-FDG and 11 C-acetate PET/CT. Results: The overall sensitivities of 18 F-FDG, 11 C-acetate, and dual-tracer PET/CT in the detection of 110 lesions in 90 patients with primary HCC were 60.9%, 75.4%, and 82.7%, respectively. Elevated serum a-fetoprotein levels, an advanced tumor stage, portal vein tumor thrombosis, large tumors, and multiple tumors were significantly associated with positive 18 F-FDG PET/CT results. Uptake of 11 C-acetate was associated with large and multiple tumors. For 18 F-FDG, the sensitivities according to tumor size (1-2, 2-5, and $5 cm) were 27.2%, 47.8%, and 92.8%, respectively; for 11 C-acetate, these respective values were 31.8%, 78.2%, and 95.2%. 18 F-FDG was more sensitive in the detection of poorly differentiated HCC. Overall survival was lower in patients with 18 F-FDG PET/CT positive for all indexed lesions than in those with FDG negative or partially positive through the entire follow-up period. In analysis based on biopsied lesions, the sensitivity of 18 F-FDG PET/CT was 64.4% for primary HCC and 84.4% for 11 C-acetate PET/CT. The overall sensitivities of 18 F-FDG, 11 C-acetate, and dual-tracer PET/CT for 35 metastatic HCCs were 85.7%, 77.0%, and 85.7%, respectively. There was no significant difference in the sensitivity of tracers according to metastatic tumor size, location, or differentiation. Conclusion: The addition of 11 C-acetate to 18 F-FDG PET/CT increases the overall sensitivity for the detection of primary HCC but not for the detection of extrahepatic metastases. 18 F-FDG, 11 C-acetate, and dual-tracer PET/CT have a low sensitivity for the detection of small primary HCC, but 18 F-FDG PET/CT has a relatively high sensitivity for the detection of extrahepatic metastases of HCC.

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Section: Imaging Studies and Biopsymentioning

confidence: 99%

“…Twenty milligrams of furosemide were administered intravenously within 10 min of the 18 F-FDG injection, and then 500 mL of water were given. 18 F-FDG (444-740 MBq [12][13][14][15][16][17][18][19][20]) was injected intravenously 4 h after 11 C-acetate PET/CT. Patients were encouraged to rest during the 18 F-FDG uptake period.…”

Section: Imaging Studies and Biopsymentioning

confidence: 99%

A Prospective Evaluation of¹⁸F-FDG and¹¹C-Acetate PET/CT for Detection of Primary and Metastatic Hepatocellular Carcinoma

Park¹,

Kim²,

Kim³

et al. 2008

J Nucl Med

252

237

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“…ACE synthesis is more often based on the method of Roeda et al [49], which leads to the creation of a compound with a short half-life (20.38 min). Patient management is easy as no fasting or particular preparation is required; the physiological uptake organs are the pancreas, bowel, kidneys and spleen.…”

Section: C-acetate (Ace)mentioning

confidence: 99%

FDG and other radiopharmaceuticals in the evaluation of liver lesions

Grassi

Morigi

Nanni

et al. 2014

Clin Transl Imaging

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Liver nodules are common findings in medical practice, both in patients with and in those without chronic liver disease. These lesions have to be interpreted according to clinical history and biochemical findings. Conventional imaging (US, CT and MRI) is still the gold standard for evaluating liver nodules, while diagnostic flowcharts do not currently include PET/CT. Since the 1990s many studies have been conducted to assess a possible role for FDG PET or PET/ CT in several liver pathologies. According to the literature, FDG PET (and later PET/CT) could be useful in detecting, staging and grading hepatocellular carcinoma, often leading to a change in therapy, and may even detect intrahepatic cholangiocarcinoma with adequate sensitivity. Moreover, FDG can allow more accurate staging of hepatic involvement deriving from other tumors (often underestimated by conventional imaging) and, therefore, more appropriate therapy in affected patients. Finally, FDG PET can also be used to evaluate 90 Y microsphere therapy response. Other conditions (e.g., primary hepatic lymphoma when conventional imaging is inconclusive) may benefit from the use of FDG PET/CT, while benign lesions (e.g., focal nodular hyperplasia) show low FDG avidity. As regards non-FDG tracers, choline and acetate (ACE) have been evaluated in comparison with FDG and found to show good efficacy in detecting and staging wellor moderately differentiated HCC. However, their sensitivity in poorly differentiated HCC is very low, suggesting that dualtracer investigation (FDG and choline/FDG and ACE) could be useful when non-invasive grading is required. Despite promising results, PET evaluation of liver nodules still seems to be far from routine application, mostly because of costrelated issues.

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“…No-carrier-added [ 11 C]carbon dioxide (see above) was released from the liquid-argon-cooled trap by warming up the latter to room temperature. A helium gas stream, dried by passage through a phosphorus pentoxide drying column (20 Method A: SmI 2 (0.1 M in THF, 300 ml) was added to the above LiEt 3 B-[ 11 C]formate complex in THF, while briefly bubbling helium gas through the mixture via the inlet needle assured homogeneity. Immediately thereafter, aqueous NaOH (0.2 N, 300 ml) was added and the reaction vial was lifted out of the cooling bath and left to stand for 1 min.…”

Section: [ 11 C]formatementioning

confidence: 99%

“…Method B: No-carrier-added [ 11 C]acetate was produced using our routine [ 11 C]acetate synthesis apparatus 20 which delivers this product on an anion exchange cartridge (Chromfix 1 PS-OH). Instead of the habitual elution with citrate buffer, the radioactivity was eluted from the cartridge with aqueous Na 2 CO 3 (0.2 N) in two fractions of 300 ml.…”

Section: Attemptedmentioning

confidence: 99%

[¹¹C]Methanol production by a fast and mild aqueous‐phase reduction of [¹¹C]formic acid with samarium diiodide

Roeda

Dollé

2006

Labelled Comp Radiopharmac

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An improvement of [11C]acetate synthesis—non-radioactive contaminants by irradiation-induced species emanating from the [11C]carbon dioxide production target

Cited by 32 publications

References 3 publications

A Prospective Evaluation of¹⁸F-FDG and¹¹C-Acetate PET/CT for Detection of Primary and Metastatic Hepatocellular Carcinoma

A Prospective Evaluation of¹⁸F-FDG and¹¹C-Acetate PET/CT for Detection of Primary and Metastatic Hepatocellular Carcinoma

FDG and other radiopharmaceuticals in the evaluation of liver lesions

[¹¹C]Methanol production by a fast and mild aqueous‐phase reduction of [¹¹C]formic acid with samarium diiodide

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An improvement of [11C]acetate synthesis—non-radioactive contaminants by irradiation-induced species emanating from the [11C]carbon dioxide production target

Cited by 32 publications

References 3 publications

A Prospective Evaluation of18F-FDG and11C-Acetate PET/CT for Detection of Primary and Metastatic Hepatocellular Carcinoma

A Prospective Evaluation of18F-FDG and11C-Acetate PET/CT for Detection of Primary and Metastatic Hepatocellular Carcinoma

FDG and other radiopharmaceuticals in the evaluation of liver lesions

[11C]Methanol production by a fast and mild aqueous‐phase reduction of [11C]formic acid with samarium diiodide

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Product

Resources

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A Prospective Evaluation of¹⁸F-FDG and¹¹C-Acetate PET/CT for Detection of Primary and Metastatic Hepatocellular Carcinoma

A Prospective Evaluation of¹⁸F-FDG and¹¹C-Acetate PET/CT for Detection of Primary and Metastatic Hepatocellular Carcinoma

[¹¹C]Methanol production by a fast and mild aqueous‐phase reduction of [¹¹C]formic acid with samarium diiodide