An improved Re/W separation protocol for preparation of carrier-free186Re

Zhu, Zihua; Wang, X. Y.; Wu, Yan; Liu, Y. F.

doi:10.1007/bf02035266

Cited by 9 publications

(3 citation statements)

References 7 publications

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“…Previously published investigations of high specific activity 186 Re production have utilized the 186 W(p,n) 186 Re or 186 W(d,2n) 186 Re reactions (Alekseev and Lazarev, 2006;Bonardi et al, 2010;Fassbender et al, 2013;Shigeta et al, 1996;Zhang et al, 2001;Zhang et al, 1999). It was concluded from those investigations that activation of 186 W by deuterons was preferred over protons as: (1) production yields are at least three time higher (Zhang et al, 2001), (2) the 186 Re radionuclidic purity is higher and remains higher (Alekseev and Lazarev, 2006;Zhu et al, 1997), and (3) lower quantities of enriched 186 W material are required for the irradiations. This latter point is important as it results in lower costs and facilitates chemical isolation of 186 Re from the target material (Bonardi et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

“…The overall goal of this investigation was to demonstrate that production-levels of high specific activity 186 Re can be obtained via the (d,2n) reaction using thick W targets. Prior reported studies have used a variety of target materials for production of 186 Re, including W metal (Bonardi et al, 2010;Zhang et al, 2001;Zhang et al, 1999), WO 3 (Fassbender et al, 2013;Moustapha et al, 2006;Shigeta et al, 1996), Al 2 (WO 4 ) 3 (Zhu et al, 1997), and W carbides (Richards et al, 2015). However, those studies were limited to "thin" target bombardments or thick target investigations using only natural abundance target 3 material.…”

Section: Introductionmentioning

confidence: 99%

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Deuteron irradiation of W and WO3 for production of high specific activity 186Re: Challenges associated with thick target preparation

Balkin

Gagnon

Strong

et al. 2016

Applied Radiation and Isotopes

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This investigation evaluated target fabrication and beam parameters for scale-up production of high specific activity (186)Re using deuteron irradiation of enriched (186)W via the (186)W(d,2n)(186)Re reaction. Thick W and WO3 targets were prepared, characterized and evaluated in deuteron irradiations. Full-thickness targets, as determined using SRIM, were prepared by uniaxially pressing powdered natural abundance W and WO3, or 96.86% enriched (186)W, into Al target supports. Alternatively, thick targets were prepared by pressing (186)W between two layers of graphite powder or by placing pre-sintered (1105°C, 12h) natural abundance WO3 pellets into an Al target support. Assessments of structural integrity were made on each target prepared. Prior to irradiation, material composition analyses were conducted using SEM, XRD, and Raman spectroscopy. Within a minimum of 24h post irradiation, gamma-ray spectroscopy was performed on all targets to assess production yields and radionuclidic byproducts. Problems were encountered with the structural integrity of some pressed W and WO3 pellets before and during irradiation, and target material characterization results could be correlated with the structural integrity of the pressed target pellets. Under the conditions studied, the findings suggest that all WO3 targets prepared and studied were unacceptable. By contrast, (186)W metal was found to be a viable target material for (186)Re production. Thick targets prepared with powdered (186)W pressed between layers of graphite provided a particularly robust target configuration.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Deuteron irradiation of W and WO3 for production of high specific activity 186Re: Challenges associated with thick target preparation

Balkin

Gagnon

Strong

et al. 2016

Applied Radiation and Isotopes

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show abstract

“…Previous studies have shown that deuteron bombardment of 186 W targets produces 186 Re yields that are at least three times higher than 186 Re produced from proton bombardment, requiring less target material [47,52,66]. In addition, the 186 Re produced by way of the 186 W(d,2n) 186 Re also reportedly achieves higher specific activities compared to proton bombardment [51,67].…”

Section: Introductionmentioning

confidence: 97%

Production of high specific activity rhenium-186 for radiotherapeutic applications and reformulation of a novel liquid brachytherapy agent

Charles¹

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The continued development of methods for the production and separation of high specific activity (HSA) rhenium-186 (t1/2 = 90.64 h, Eb-ave = 359 keV (71 percent), 306 keV (22 percent)) would largely increase its use as a therapeutic analogue to the widely used 99mTc (t1/2 = 6.01 h, Eg = 141 keV (89 percent)). Rhenium-186 has favorable decay properties that make it an attractive candidate for radioimmunotherapy, providing that the radionuclide can be obtained in high specific activity. The similar chemical characteristics of Re and Tc in theory may allow 186Re-based radiopharmaceuticals to be developed as therapeutic analogues to their 99mTc counterparts. In this research, two methods were evaluated for the production and separation of HSA 186Re, and several methods were also evaluated for their efficiency in the selective separation of 186Re post production, as well as high recovery of the costly enriched target material. Yttrium-90 (t1/2 = 64 h, Eb-max = 2.28 MeV (99.99 percent)) also displays excellent decay properties for targeted radiotherapy, which is exploited by the formulation of a novel liquid brachytherapy agent, BetaBrachTM. The HSA 90Y utilized for the current formulation of BetaBrachTM can be replaced by low specific activity (LSA) 90Y produced in a nuclear reactor. Replacing HSA 90Y with LSA 90Y may offer significant economic advantages if the demand for BetaBrachTM requires large scale production of 90Y. Thus, this work also evaluates the chemical and physical characterization of LSA 90Y formulated BetaBrachTM as well as its therapeutic efficacy.

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Comments on the cross sections of186Re in the186W(p,n) and186W(d, 2n) reactions in connection to the paper given by Z. H. Zhu et al. and correction of the calculated yields of186Re in the186W(p, n) reaction

Ishioka¹,

Sekine²,

Lambrecht

1999

J Radioanal Nucl Chem

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An improved Re/W separation protocol for preparation of carrier-free186Re

Cited by 9 publications

References 7 publications

Deuteron irradiation of W and WO3 for production of high specific activity 186Re: Challenges associated with thick target preparation

Deuteron irradiation of W and WO3 for production of high specific activity 186Re: Challenges associated with thick target preparation

Production of high specific activity rhenium-186 for radiotherapeutic applications and reformulation of a novel liquid brachytherapy agent

Comments on the cross sections of186Re in the186W(p,n) and186W(d, 2n) reactions in connection to the paper given by Z. H. Zhu et al. and correction of the calculated yields of186Re in the186W(p, n) reaction

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