An improved pH-responsive carrier based on EDTA-Ca-alginate for oral delivery of Lactobacillus rhamnosus ATCC 53103

Zheng, Huizhen; Gao, Meng; Ren, Ying; Lou, Ruyun; Xie, Hehu; Yu, Wenwu; Liu, Xiudong; Ma, Xiaojun

doi:10.1016/j.carbpol.2016.08.096

Cited by 70 publications

(39 citation statements)

References 20 publications

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“…The development of a microencapsulation matrix can provide a physical barrier during food processing, storage and in the conditions simulating of the gastrointestinal tract (D'Orazio et al 2015). In this regard, microencapsulation of probiotics into hydrocolloid beads prepared by extrusion (Shaharuddin and Muhamad 2015) and emulsion (Zhao et al 2017, Zheng et al 2017) techniques or into spray-dried microparticles (Santos et al 2014), has been investigated (Doleyres and Lacroix 2005). Alginate is often used as an encapsulating material because it has the benefits of being non-toxic and being readily available (Ding and Shah 2008, Chávarri et al 2010, Pitigraisorn et al 2017, besides this, it is a naturally occurring biocompatible and biodegradable linear anionic polysaccharide (Lotfipour et al 2012).…”

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confidence: 99%

Preparation and characterization of alginate and gelatin microcapsules containing Lactobacillus rhamnosus

Lopes

Bueno

Aguiar

et al. 2017

An. Acad. Bras. Ciênc.

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This paper describes the preparation and characterization of alginate beads coated with gelatin and containing Lactobacillus rhamnosus. Capsules were obtained by extrusion method using CaCl 2 as cross linker. An experimental design was performed using alginate and gelatin concentrations as the variables investigated, while the response variable was the concentration of viable cells. Beads were characterized in terms of size, morphology, scanning electron microscopy (SEM), moisture content, Fourier Transform Infrared Spectrometry (FTIR), thermal behavior and cell viability during storage. The results showed that the highest concentration of viable cells (4.2 x 10 9 CFU/g) was obtained for 1 % w/v of alginate and 0.1 % w/v of gelatin. Capsules were predominantly spherical with a rough surface, a narrow size distribution ranging from 1.53 to 1.90 mm and a moisture content of 97.70 ± 0.03 %. Furthermore, FTIR and thermogravimetric analysis indicated an interaction between alginate-gelatin. Cell concentration of alginate/gelatin microcapsules was 10 5 CFU/g after 4 months of storage at 8 o C.

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mentioning

confidence: 99%

Preparation and characterization of alginate and gelatin microcapsules containing Lactobacillus rhamnosus

Lopes

Bueno

Aguiar

et al. 2017

An. Acad. Bras. Ciênc.

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“…Simple microgels typically consist of small spherical particles that contain a network of cross‐linked biopolymers inside, with the pores being filled by an aqueous solution. Various kinds of microgels have been explored for their potential as oral delivery systems for probiotics (Cook, Tzortzis, Charalampopoulos, & Khutoryanskiy, ; Huq et al., ; Khosravi Zanjani, Ghiassi Tarzi, Sharifan, & Mohammadi, ; Pankasemsuk et al., ; Saravanan and Panduranga, ; Trabelsi et al., ; Yeung, Ucok et al., ; Zheng et al., ). The materials used to fabricate microgels are typically biopolymers, such as starch, alginate, carrageenan, gelatin, xanthan gum, and proteins, which usually have good thermal stability, high biocompatibility, low toxicity, and low cost (Huq, Khan, Khan, Riedl, & Lacroix, ; Islam, Yun, Choi, & Cho, ).…”

Section: Microencapsulation Of Probioticsmentioning

confidence: 99%

“…Studies have also demonstrated that doping microgels with cellulose nanoparticles (CNCs) significantly enhances the resistance of probiotics under simulated gastric conditions by filling the pores and thereby reducing the entry of gastric acids (Huq et al., ). More recently, pH‐responsive carrier particles composed of a mixture of calcium, alginate, and EDTA have been developed (Zheng et al., ). This system is gel‐like under acidic conditions, but breaks down under neutral conditions, and may therefore also be used to retain probiotics in the stomach but release them in the small intestine.…”

Section: Microencapsulation Of Probioticsmentioning

confidence: 99%

Progress in microencapsulation of probiotics: A review

Yao

Xie

et al. 2020

Comp Rev Food Sci Food Safe

264

160

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The potential health benefits of probiotics may not be realized because of the substantial reduction in their viability during food storage and gastrointestinal transit. Microencapsulation can be used to enhance the resistance of probiotics to unfavorable conditions. A range of oral delivery systems has been developed to increase the level of probiotics reaching the colon including embedding and coating systems. This review introduces emerging strategies for the microencapsulation of probiotics and highlights the key mechanisms of their stress–tolerance properties. Recent in vitro and in vivo models for evaluation of the efficiency of probiotic delivery systems are also reviewed. Encapsulation technologies are required to maintain the viability of probiotics during storage and within the human gut so as to increase their ability to colonize the colon. These technologies work by protecting the probiotics from harsh environmental conditions, as well as increasing their mucoadhesive properties. Typically, the probiotics are either embedded inside or coated with food‐grade materials such as biopolymers or lipids. In some cases, additional components may be coencapsulated to enhance their viability such as nutrients or protective agents. The importance of having suitable in vitro and in vivo models to evaluate the efficiency of probiotic delivery systems is also emphasized.

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“…A very widespread model known as egg box is used to explain this type of gelation [26]. The alginate/Ca 2+ matrix may be broken down under acidic conditions and/or by the addition of EDTA [27].…”

Section: Basic Concepts and Useful Properties Of Hydrogelsmentioning

confidence: 99%

Hydrogels Based on Chitosan and Chitosan Derivatives for Biomedical Applications

Rufato¹,

Galdino²,

Ody³

et al. 2019

Hydrogels - Smart Materials for Biomedical Applications

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Chitosan (CS) is a polymer obtained from chitin, being this, after the cellulose, the most abundant polysaccharide. The fact of (i) CS being obtained from renewable sources; (ii) CS to possess capability for doing interactions with different moieties being such capability dependent of pH; (iii) plenty of possibilities for chemical modification of CS; and (iv) tuning the final properties of CS derivatives makes this polymer very interesting in academic and technological points of view. In this way, hydrogels based on CS and on CS derivatives have been widely used for biomedical applications. Other important technological applications can be also cited, such as adsorbent of metals and dyes in wastewater from industrial effluents. In pharmaceutical field, hydrogels based on CS are often used as drugs' and proteins' carrier formulations due to the inherent characteristics such as the biocompatibility, nontoxicity, hydrophilicity, etc. This chapter is an attempt for updating and joining the plenty of available information regarding the preparation, characterization, and biomedical application of hydrogels based on chitosan and chitosan derivatives. More than 260 references are provided, being the majority of them published in the last 10 years.

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An improved pH-responsive carrier based on EDTA-Ca-alginate for oral delivery of Lactobacillus rhamnosus ATCC 53103

Cited by 70 publications

References 20 publications

Preparation and characterization of alginate and gelatin microcapsules containing Lactobacillus rhamnosus

Preparation and characterization of alginate and gelatin microcapsules containing Lactobacillus rhamnosus

Progress in microencapsulation of probiotics: A review

Hydrogels Based on Chitosan and Chitosan Derivatives for Biomedical Applications

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