An improved method for the determination of fluticasone propionate in human plasma

Minimizing matrix effects in the development of a method for the determination of salmeterol in human plasma by LC/MS/MS at low pg/mL concentration levels

“…Maximum peak plasma concentrations of fluticasone after inhalation of therapeutic doses were reported to be approximately 100 pg/mL [20][21][22][23] but concentrations of up to 245 pg/mL were also reported [24]. In addition, Michael et al reported possible formation of inter-molecular adducts of salmeterol and fluticasone in solution and in the ionization source of MS detector [25,26], which may complicate the determination of salmeterol in the presence of fluticasone.…”

Micronization of Fluticasone Propionate using Supercritical Antisolvent (SAS) Process

“…In this study, a SAS process was employed for recrystallization of an asthma drug, fluticasone propionate. Fluticasone propionate is a synthetic corticosteroid with high anti-inflammatory activity, which is used to treat asthma and allergic rhinitis [23]. The feasibility study on micronization of steroids including fluticasone propionate, using the SAS process, has been demonstrated by Steckel et al [24].…”

HPTLC-densitometric method for simultaneous determination of salmeterol xinafoate and fluticasone propionate in dry powder inhalers

“…1b) is a neutral, highly potent trifluorinated corticosteroid based on the androstane nucleus. It is effective in treatments of asthma and allergic rhinitis because of its anti-inflammatory activity (Laugher et al, 1999;Krishnaswami et al, 2000). These two drugs are formulated as dry powder inhalers or pressurized metered dose inhalers individually or in combined formulation (Ringdal et al, 2007).…”