An Improved Method for Preparation of Cefpodoxime Proxetil.

Abstract

method is presented for the synthesis of cefpodoxime proxetil (XII), a third-generation cephalosporin for oral administration. Compared to previously reported methods the new procedure affords better yields and no purification step by column chromatography is necessary. -(RODRIGUEZ, J. C.; HERNANDEZ, R.; GONZALEZ, M.; RODRIGUEZ, Z.; TOLON, B.; VELEZ, H.; VALDES, B.; LOPEZ, M. A.; FINI*, A.; Farmaco 58 (2003) 5, 363-369; Ist. Sci. Chim., Univ. Bologna, I-40127 Bologna, Italy; Eng.) -M. Bohle 36-177

Interaction of CFP with Metal ions: Complex Formation of CFP with Metal ion by Absorption and Fluorescence Spectrophotometery

“…In biological system cefpodoxime undergoes ester hydrolysis and converted into cefpodoxime acid to exhibit its antibiotic activity. 1,2 It has an asymmetric carbon at position 4 and is supplied as racemic mixture of R and S-enantiomers. Only a few methods are reported to quantify 7 were major breakthroughs in the history of β-lactam antibiotics.…”