An Improved Lc-MS/MS Method Development and Validation for the Determination of Trandolapril and Verapamil in Human Plasma

Ravi, Yatha; Rajkamal, B.

doi:10.22159/ijpps.2019v11i3.31247

Cited by 5 publications

(5 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Manufacturers are obliged to make their choices from a predefined roster of preservatives outlined in the EU Cosmetics Regulation. These preservatives have undergone rigorous scientific assessments and approval processes, including evaluations by the Scientific Committee on Consumer Safety (SCCS) [15]. In the EU, ingredients in cosmetic products must be indicated/labelled following EU legislation.…”

Section: Europementioning

confidence: 99%

Elemental burdens of cosmetics and associated health and environmental impacts: A global view

Ebenezer Ebo Yahans Amuah,

Kwabena Antwi,

Nelson Awuah Ankamah

2023

World J. Adv. Res. Rev.

View full text Add to dashboard Cite

The use of diverse chemicals in beauty, skin, hair, and nail care products may be traced back to ancient times. Preservatives, stabilizers, mineral pigments, colour, and shine were added to these goods to improve their quality and increase their effects. This review which covers 28 countries, highlights the heavy metal content of some cosmetics, and their associated health and environmental implications, and the use of multivariate statistics to understand the dynamics and interrelationship between the elements. From the study, cosmetic products pose debilitating impacts on human health because some products contain potentially toxic elements including Pb, Zn, Cd, As, Fe, Sb, Cr, Co, Hg, and Ni beyond allowable levels. However, the concentrations of these elements in cosmetics are country, product, and manufacturer variants. Principal Component Analysis (PCA) and correlation matrix revealed possible interrelationships between different elements in cosmetic products, which have harmful implications. This suggests potential harmful interactions and the need for strict safety measures in their formulation and usage. Indiscriminate disposal of these products containing toxic heavy metals may pose detrimental impacts on the environment and various ecological systems. It is recommended that manufacturers of cosmetics invest in non-toxic materials that pose no or fewer impacts on the environment and consumer health.

show abstract

Section: Europementioning

confidence: 99%

Elemental burdens of cosmetics and associated health and environmental impacts: A global view

Ebenezer Ebo Yahans Amuah,

Kwabena Antwi,

Nelson Awuah Ankamah

2023

World J. Adv. Res. Rev.

View full text Add to dashboard Cite

show abstract

“…Document that serves as a guide for submitting an application for registration certification. Importing cosmetics requires Form 43 [25]. Manufacturer has a responsibility to determine the shelf life of cosmetic products.…”

Section: Time Duration Of Import Of Cosmeticsmentioning

confidence: 99%

“…It is the responsibility of the cosmetics manufacturer or importer to demonstrate that the product is safe for its intended usage. [25].…”

Section: Time Duration Of Import Of Cosmeticsmentioning

confidence: 99%

The Review on Cosmetic Regulation: Quality Education

Chauhan¹,

Chauhan²,

Nainwani³

2022

ECS Trans.

View full text Add to dashboard Cite

The cosmetics industry is undergoing substantial transformations all over the world. It has grown dramatically over the world, providing a means for a person to alter his or her appearance and make a product instantly noticeable and appealing. To accomplish effective promoting, one must consider a variety of factors. Today's cosmetic industry or market takes use of cutting-edge technology to create new cosmetic agents with enhanced qualities. Trend for cosmetics is getting elevated each passing day, hence enormous growth is encountered in the cosmetic market globally. If we talk about legislation of the cosmetic industries nowadays then they are kind of stringent all over the globe. There are different regulatory bodies globally with their own rules and regulation regarding cosmetics. The major market for cosmetics is in United states and in European Union, and all other developing countries ideally look the regulation of these developed countries as a role model. Despite of all the differences in regulatory bodies their aim is somewhat similar which is to ensure the safety, efficacy, and stability of the product. So, in this article we are going to study about the various differences which are present regarding the regulatory bodies and rules and regulation among India, United States and European Union.

show abstract

“…At each concentration level, percentage recoveries were calculated, and finally, overall mean recovery was calculated. The ME was analyzed by paralleling the un-extracted samples with post-extracted samples [14][15][16].…”

Section: Recovery and Mementioning

confidence: 99%

Method Development and Validation for the Estimation of Amprenavir in Human Plasma by Liquid Chromatography–electrospray Ionization–tandem Mass Spectrometry

Susmitha

Menaka

2019

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective: The main aim of the present study was to develop a sensitive liquid chromatography–electrospray ionization–tandem mass spectrometric technique for the quantitation of amprenavir in human plasma. Methods: Chromatographic separation was achieved on a reversed-phase Symmetry C18 (50 mm×4.6 mm, 3.5 μm) column with isocratic elution by acetonitrile and 0.1% v/v formic acid in the ratio of 90:10 v/v as mobile phase. Chromatographic peaks were resolved with 0.7 ml/min flow rate. Drug was extracted with ethyl acetate solvent by liquid–liquid extraction method. Monitoring of transition of m/z 506.2 and 71.0 for amprenavir and 628 and 421 for methyl-indinavir was made on multiple reaction monitoring. Results: Calibration curve of amprenavir was linear over 1–600 ng/ml concentration range with regression coefficient (r2) value of >0.99. The % relative standard deviation values were <8.5% for interday and intraday precision and accuracy. The method has excellent recovery, and the percentage recovery values of lower quality control (QC), median QC, and higher QC samples were 101.86%, 102.8%, and 99.28%, respectively. Conclusion: The drug was stable for more time at variable stability conditions, and method was successfully applicable to regular analysis of amprenavir in biological matrices.

show abstract

An Improved Lc-MS/MS Method Development and Validation for the Determination of Trandolapril and Verapamil in Human Plasma

Cited by 5 publications

References 16 publications

Elemental burdens of cosmetics and associated health and environmental impacts: A global view

Elemental burdens of cosmetics and associated health and environmental impacts: A global view

The Review on Cosmetic Regulation: Quality Education

Method Development and Validation for the Estimation of Amprenavir in Human Plasma by Liquid Chromatography–electrospray Ionization–tandem Mass Spectrometry

Contact Info

Product

Resources

About