The purpose of this work is to provide support for the design of cushioning packaging materials for products with unbalanced mass distributions. A mathematical model of the cushioning packaging system is established and the fourth-order Runge–Kutta method is used to compare the vibration response of products with balanced and unbalanced mass. Finite element simulations are conducted to demonstrate the feasibility of the proposed method of optimizing the design of cushioning packaging materials for products with unbalanced mass distributions using various damping materials. The simulation results are verified by experiments. The results show that the magnitude of the mass offset has a large effect on the acceleration of damped cushioning packaging systems for products with unbalanced mass. The vibration response can be corrected by appropriately increasing the damping coefficient at the mass offset end, thus providing an effective method of optimizing the design of cushioning packaging for products with unbalanced mass.