An improved automatic time-of-flight picker for medical ultrasound tomography

Li, Cuiping; Huang, Lianjie; Duric, Nebojsa; Zhang, Haijiang; Rowe, C. A.

doi:10.1016/j.ultras.2008.05.005

Cited by 127 publications

(94 citation statements)

References 21 publications

(38 reference statements)

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“…The images are produced from algorithms that utilize "bent-ray" tomographic techniques for greater computational efficiency while accounting for refractive effects. 30,31 The exam is operator independent and, since the method is based on acquiring acoustic signals, there is no ionizing radiation.…”

Section: Iic Ust Measurementsmentioning

confidence: 99%

“…Our previous studies have shown results consistent with this relationship. [29][30][31][32] This paper presents results from a study comparing the volume averaged sound speed (VASS) of the breast with mammographic percent density (MPD). The purpose of the study was to determine whether VASS is a viable measure of BD and a possible alternative to MPD.…”

Section: Introductionmentioning

confidence: 99%

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Breast density measurements with ultrasound tomography: A comparison with film and digital mammography

et al. 2013

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Purpose:To investigate the use of the whole-breast sound speed measurement as a marker of breast density (BD), a known risk factor for breast cancer. Methods: As part of an ongoing study of breast cancer detection, 249 patients were scanned with a clinical prototype that operates on the principles of ultrasound tomography. Typically, 40-100 sound speed tomograms were reconstructed from the scan data, corresponding to the entire volume of the breast of each patient. The data were used to estimate the volume averaged sound speed (VASS) of the breast for each patient. The corresponding mammograms were used to calculate mammographic percent density (MPD) using CUMULUS software. Film mammograms were available for 164 patients while 85 digital mammograms were available for the remaining patients. Standard statistical techniques were used to determine associations of breast sound speed with a variety of mammographic measures such as percent density, area of dense tissue, and area of nondense tissue. Furthermore, associations of breast sound speed with continuous variables such as age and weight and dichotomous variables such as parity and menopausal status were also assessed. Results: VASS was found to be significantly associated with MPD. The Spearman correlation coefficient (r s ) between VASS and MPD was found to be 0.77 and 0.71 for film and digital mammography, respectively. VASS was positively correlated with dense areas by mammography, both digital (r s = 0.46) and film (r s = 0.56). VASS was negatively associated with nondense area by mammography, both digital (r s = −0.58) and film (r s = −0.63). BD by all methods was less in postmenopausal than in premenopausal women. The MPD was lower in the postmenopausal group (by 6.6%, p < 0.08, for the digital group and 7.73%, p < 0.007, for the film group). The VASS was also lower in the postmenopausal group (by 15 m/s, p < 0.001 for the digital group and 8 m/s, p < 0.08, for the film group). The association of MPD with age was characterized with r s = −0.06 (p < 0.6) for digital mammography and r s = −0.53 (p < 0.002) for film mammography. For weight, the MPD associations were characterized by r s = −0.53 (p < 0.0001) for digital mammography and −0.38 (p < 0.0001) for film mammography. The association of VASS with age was r s = −0.33 (p < 0.002) for the digital group and −0.17 (p < 0.03) for the film group. For weight, the relationship was characterized with r s = −0.45 (p < 0.001) for the digital group and −0.37 (p < 0.0001) for the film group. Conclusions: The association between VASS and MPD is strong for both film and digital mammography, suggesting that VASS is a viable measure of breast density. This result sets the stage for future work that will focus on directly testing the association of VASS with breast cancer risk.

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Section: Iic Ust Measurementsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Breast density measurements with ultrasound tomography: A comparison with film and digital mammography

et al. 2013

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“…Another important factor influencing the performance of our algorithm is signal-to-noise ratio of the acquired patient data. Although our in-house time-of-flight picker was tolerant to white noise, coherent noise in the ultrasound data might still affect the performance of the picker (Li et aL, 2009). Thus, low signal-to-noise of the data might affect the accuracy of our time-of-flight picks.…”

Section: Comparison Inmentioning

confidence: 99%

Ultrasonographic Evaluation of Hyoid–Larynx Approximation in Dysphagic Stroke Patients

Huang

Hsieh

Chang

et al. 2009

Ultrasound in Medicine & Biology

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We discuss a bent-ray ultrasound tomography algorithm with total-variation (TV) regularization.We have applied this algorithm to 61 in vivo breast datasets collected with our in-house clinical prototype for imaging sound-speed distributions in the breast. Our analysis showed that TV regularization could preserve sharper lesion edges than the classic Tikhonov regularization.Furthermore, the image quality of our TV bent-ray sound-speed tomograms was superior to that of the straight-ray counterparts for all types of breasts within BI-RADS density categories 1-4.For all four breast types from fatty to dense, the improvements for average sharpness (in the unit of (m· s) -1) of lesion edges in our TV bent-ray tomograms are between 2.1 to 3.4 fold compared to the straight ray tomograms. Reconstructed sound-speed tomograms illustrated that our algorithm could successfully image fatty and glandular tissues within the breast. We calculated the mean sound-speed values for fatty tissue and breast parenchyma as 1422 ± 9 ml s (mean± SD) and1487 ± 21 ml s, respectively. Based on 32 lesions in a cohort of 61 patients, we also found that the mean sound-speed for malignant breast lesions (1548±17 mls) was higher, on average, than that of benign ones (1513±27 mls) (one-sided p

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“…The time-of-flight was determined using an automated picker [18], and the speed of sound was computed from…”

Section: Signal Processingmentioning

confidence: 99%

Acoustical characterisation of carbon nanotube-loaded polydimethylsiloxane used for optical ultrasound generation

Alles

Heo

Noimark

et al. 2017

2017 IEEE International Ultrasonics Symposium (IUS)

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Abstract-An optical ultrasound generator was used to perform broadband (2 − 35 MHz) acoustical characterisation measurements of a nanocomposite comprising carbon nanotubes (CNT) and polydimethylsiloxane (PDMS), a composite that is commonly used as optical ultrasound generator. Samples consisting of either pure PDMS or CNT-loaded PDMS were characterised to determine the influence of CNTs on the speed of sound and power-law acoustic attenuation parameters. A small weight fraction (< 1.8%) of added CNTs was found to yield a prominent increase in the exponent of the power law, resulting in a significant increase in acoustic attenuation at higher frequencies. The speed of sound was found to be nearly identical, however. These results could prove useful in the numerical modelling and design of future optical ultrasound sources based on CNT-loaded PDMS.

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An improved automatic time-of-flight picker for medical ultrasound tomography

Cited by 127 publications

References 21 publications

Breast density measurements with ultrasound tomography: A comparison with film and digital mammography

Breast density measurements with ultrasound tomography: A comparison with film and digital mammography

Ultrasonographic Evaluation of Hyoid–Larynx Approximation in Dysphagic Stroke Patients

Acoustical characterisation of carbon nanotube-loaded polydimethylsiloxane used for optical ultrasound generation

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