An imprinted signature helps isolate ESC-equivalent iPSCs

Lujan, Ernesto; Wernig, Marius

doi:10.1038/cr.2010.117

Cited by 3 publications

(2 citation statements)

References 10 publications

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“…178 These genes have important roles in embryogenesis and post-natal behaviour. In particular, they have been implicated in regulation of stem-cell properties of embryonic stem cells as well as cancer stem cells, 179,180 especially the reciprocally imprinted gene pair consisting of the paternally expressed DLK1 gene and the maternally expressed non-coding RNA gene MEG3. 181,182 The epigenetic regulation of the 14q32.2 cluster is similar to that of the IGF2/H19 cluster on chromosome 11p15.5, where the promoter of an ncRNA (H19) contains a DMR whose methylation status influences the activity of a protein-coding gene (IGF2).…”

Section: Meg3/gtl2 Dlk1 and The 14q322 Imprinted Gene Clustermentioning

confidence: 99%

Specific changes in the expression of imprinted genes in prostate cancer—implications for cancer progression and epigenetic regulation

Ribarska¹,

Bastian²,

Koch³

et al. 2012

Asian J Androl

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Epigenetic dysregulation comprising DNA hypermethylation and hypomethylation, enhancer of zeste homologue 2 (EZH2) overexpression and altered patterns of histone modifications is associated with the progression of prostate cancer. DNA methylation, EZH2 and histone modifications also ensure the parental-specific monoallelic expression of at least 62 imprinted genes. Although it is therefore tempting to speculate that epigenetic dysregulation may extend to imprinted genes, expression changes in cancerous prostates are only well documented for insulin-like growth factor 2 (IGF2). A literature and database survey on imprinted genes in prostate cancer suggests that the expression of most imprinted genes remains unchanged despite global disturbances in epigenetic mechanisms. Instead, selective genetic and epigenetic changes appear to lead to the inactivation of a sub-network of imprinted genes, which might function in the prostate to limit cell growth induced via the PI3K/Akt pathway, modulate androgen responses and regulate differentiation. Whereas dysregulation of IGF2 may constitute an early change in prostate carcinogenesis, inactivation of this imprinted gene network is rather associated with cancer progression.

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Section: Meg3/gtl2 Dlk1 and The 14q322 Imprinted Gene Clustermentioning

confidence: 99%

Specific changes in the expression of imprinted genes in prostate cancer—implications for cancer progression and epigenetic regulation

Ribarska¹,

Bastian²,

Koch³

et al. 2012

Asian J Androl

View full text Add to dashboard Cite

show abstract

“…By combining a number of these observations several laboratories have developed schemes for the selection of those lines that have been reprogrammed accurately (Bock et al., 2011; Chan et al., 2009). Others have placed great emphasis on correct regulation of imprinted genes (Lujan and Wernig, 2010). Most recently, a systematic survey of cell surface glycoproteins has been initiated with the hope that this may define cell surface patterns that are cell type specific (Gundry et al., 2012).…”

Section: Basic Principles Of Human Somatic Cell Reprogrammingmentioning

confidence: 99%

Using human induced pluripotent stem cells to treat retinal disease

Borooah

Phillips

Bilican

et al. 2013

Progress in Retinal and Eye Research

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The eye is an ideal target for exploiting the potential of human induced pluripotent stem cell (hiPSC) technology in order to understand disease pathways and explore novel therapeutic strategies for inherited retinal disease. The aim of this article is to map the pathway from state-of-the art laboratory-based discoveries to realising the translational potential of this emerging technique. We describe the relevance and routes to establishing hiPSCs in selected models of human retinal disease. Additionally, we define pathways for applying hiPSC technology in treating currently incurable, progressive and blinding retinal disease.

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DLK1-DIO3 imprinted cluster in induced pluripotency: landscape in the mist

Benetatos¹,

Vartholomatos

Hatzimichael

2014

Cell. Mol. Life Sci.

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DLK1-DIO3 represents an imprinted cluster which genes are involved in physiological cell biology as early as the stem cell level and in the pathogenesis of several diseases. Transcription factor-mediated induced pluripotent cells (iPSCs) are considered an unlimited source of patient-specific hematopoietic stem cells for clinical application in patient-tailored regenerative medicine. However, to date there is no marker established able to distinguish embryonic stem cell-equivalent iPSCs or safe human iPSCs. Recent findings suggest that the DLK1-DIO3 locus possesses the potential to represent such a marker but there are also contradictory data. This review aims to report the current data on the topic describing both sides of the coin.

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An imprinted signature helps isolate ESC-equivalent iPSCs

Cited by 3 publications

References 10 publications

Specific changes in the expression of imprinted genes in prostate cancer—implications for cancer progression and epigenetic regulation

Specific changes in the expression of imprinted genes in prostate cancer—implications for cancer progression and epigenetic regulation

Using human induced pluripotent stem cells to treat retinal disease

DLK1-DIO3 imprinted cluster in induced pluripotency: landscape in the mist

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