An Important Potential Anti-Epileptic/Anticonvulsant Active Group: A Review of 1,2,4-Triazole Groups and Their Action

Abstract

Epilepsy is one of the most common encountered neurological disorders. Many individuals continue to have seizures despite medical and surgical treatments, suggesting new antiepileptic/anticonvulsant drugs are required. Triazole compounds are widely used in pharmaceuticals and have gained significant importance in medicinal chemistry. This article is an attempt to systematically review the research of triazole derivatives in the design and development of anticonvulsant agents during the past two decades through extensive literature research. The results show that triazole occupy a distinct niche in heterocyclic chemistry and represent a key motif in medicinal chemistry because of their capability to exhibit an array of properties and bioactivities, Therefore, 1,2,4-triazole seems to be an important pharmacophore, especially in the field of antiepileptic, which is of great explored potentiality and utilized value. Through in-depth research on this type of structure, it is believed that more 1,2,4-triazole compounds will be developed as anti-epileptic drugs for clinical use.

Effect of Linker Elongation on the VGSC Affinity and Anticonvulsant Activity among 4-Alkyl-5-aryl-1,2,4-triazole-3-thione Derivatives

“…According to the literature, compounds possessing 1,2,4-triazole ring in their structures are characterized by high antiepileptic potential [ 10 , 11 , 12 , 13 , 14 ]. Among them, 4-alkyl-5-aryl-1,2,4-triazole-3-thione derivatives express anticonvulsant activity both against tonic–clonic seizures and in an animal model of drug-resistant epilepsy [ 15 , 16 , 17 ].…”

Synthetic and Medicinal Perspective of 1,2,4‐Triazole as Anticancer Agents

“…Literature data concluded that, fused heteroaromatic system exhibited excellent biological activity like N-alkyl-6-nitro-3,5-dihydro [1,2,4]triazolo [1,5-a]pyrimidin-7-amine, [1,2,4]triazolo [1,5-c]pyrimidines exhibited anticonvulsant and antiparasitic activity, respectively, as shown in Figure 1. [1] Among the heterocyclic systems, 1,2,4-triazole and its derivatives attracted synthetic and medicinal chemist due to various pharmacological potential like anxiolytic, [2][3][4][5] antibacterial, [6][7][8][9] anti-parasitic, [10] antiviral, [11] anti-oxidant, [12] fungicide, [13][14][15] antituberculosis, [16] antiepileptic, [17] antitumor. [18 -20] 1,2,4triazoles are derived from pyrazole via substituting doi.org/10.1002/cbdv.202200679 carbon by nitrogen atom at position 4, it acts as isosteres of ester, amide and carboxylic acid.…”

“…Among the heterocyclic systems, 1,2,4‐triazole and its derivatives attracted synthetic and medicinal chemist due to various pharmacological potential like anxiolytic, [2–5] antibacterial, [6–9] anti‐parasitic, [10] antiviral, [11] anti‐oxidant, [12] fungicide, [13–15] anti‐tuberculosis, [16] antiepileptic, [17] antitumor [18–20] . 1,2,4‐triazoles are derived from pyrazole via substituting carbon by nitrogen atom at position 4, it acts as isosteres of ester, amide and carboxylic acid.…”