An Implantable Magnetic Vascular Scaffold for Circulating Tumor Cell Removal In Vivo

Abstract

An integrated trapped device (ITD) capable of removal of circulating tumor cells (CTCs) can assuage or even prevent metastasis. However, adhesion repertoires are ordinarily neglected in the design of ITDs, possibly leading to the omission of highly metastatic CTC and treatment failure. Here a vascular‐like ITD with adhesive sites and wireless magnetothermal response to remove highly metastatic CTC in vivo is presented. Such a vascular‐like ITD comprises circumferential well‐aligned fibers and artificial adhesion repertoires and is optimized for magnetothermal integration. Continuous and repeated capture in a dynamic environment increases capture efficiency over time. Meanwhile, the heat generation of the ITD leads to the capture of CTC death owing to cell heat sensitivity. Furthermore, the constructed bioinspired ultrastructure of the ITD prevents vascular blockage and induces potential vascular regeneration. Overall, this work defines an extendable strategy for constructing adhesion repertoires against intravascular shear forces, provides a vascular‐like ITD for reducing CTC counts, and is expected to alleviate the risk of cancer recurrence.

Recent progress of nanostructure-based enrichment of circulating tumor cells and downstream analysis

“…10C, Yin et al proposed for the first time a vascular integrated trapped device (ITD), which is an implantable HA modified magnetic vascular stent (HA-MVS) for the permanent capture and magnetothermal ablation of CD44 positive (CD44+) CTCs under an alternating magnetic field (AMF). 152 The HA-MVS can capture CTCs repeatedly in a dynamic environment (flow rate = 5.0 mL min −1 ). In the setting of extracorporeal closed-loop circulation, the capture efficiency reached 21.6 ± 1.5% after 120 cycles, and 13.26 ± 4.22% in rats after 3 hours of in vivo circulation.…”

Magnetic Graphitic Nanocapsules: Fabrication, Classification, and Theranostic Applications

“…Copyright 2022 American Chemical Society. Reprinted in part with permission from ref . Copyright 2022 John Wiley and Sons.…”

Cancer Traps: Implantable and On‐Chip Solutions for Early Cancer Detection and Treatment

“…Specifically, a vascular‐like system containing adhesive sites and the wireless magnetothermal response was recently reported for the continuous capture and removal of CD44‐positive CTCs in vivo (Figure 3D). [ 52 ] The device was made of poly( l ‐lactic acid) fibers encapsulated with FeCo nanocrystals and modified with hyaluronic acid and gelatin to form artificial adhesion sites for capturing the cells. Cell death was accomplished through magnetothermal ablation under an alternating magnetic field.…”

“…D) Scheme describing the step-by-step capture and removal of CD44+ CTCs by the vascular-like integrated trapped device. Reproduced with permission [52]. Copyright 2022, Wiley-VCH GmbH.…”