An implantable left ventricular-aortic assist device

Rm, Filler; Wf, Bernhard; Bankole, Michael A.; Cg, LaFarge; Robinson, Timothy

doi:10.1016/s0022-5223(19)43019-5

Cited by 28 publications

(3 citation statements)

References 6 publications

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“…An important limiting factor in reducing the size of the pump was its drive mechanism (11)(12)(13)(14)(15)(16)(17)(18)(19). We adopted the cross slider form with motor to make a small size driving mechanism.…”

Section: Discussionmentioning

confidence: 99%

Recent Progress on the Vibrating Flow Pump as a Totally Implantable Ventricular Assist Device

et al. 2001

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This study describes the present state of progress in the development of the vibrating flow pump (VFP) ventricular assist system. We have proceeded with development aiming at a totally implantable ventricular assist system with smaller size and lighter weight appropriate for Asians like the Japanese by increasing the drive frequency. An actuator is important for the development of the miniature sized and lightweight artificial heart. We applied a linear motor for the mechanical part at first. The step motor was applied after that. This form may be best if we want the lightweight small sized motor for an actuator. The cross slider form is applied at present. It succeeded in the miniaturization compared with the linear motor. In the VFP-type ventricular assist system, the blood contact parts are a central vibration tube with inflow and outflow chambers. We designed round diaphragms to prevent thrombus formation. In addition, we developed an energy transmission system for total implantation. The VFP creates a high frequency oscillated blood flow. It has a unique flow pattern. Brain blood flow increased although the total flow of the circulation did not change in the frequency of 25 to 30 Hz. The quantitative evaluation of the autonomic nerve function during the left heart assistance with an oscillated blood flow was carried out by spectral analysis. Some influences on an autonomic nerve were observed by the VFP left heart assistance. We will continue development research with the aim of clinical application.

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Section: Discussionmentioning

confidence: 99%

Recent Progress on the Vibrating Flow Pump as a Totally Implantable Ventricular Assist Device

et al. 2001

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“…The purpose of the NHLBI program was to evaluate periods of assisted circulation (less than 2 weeks) in postcardiotomy patients who might have a reversible form of left ventricular dysfunction [1][2][3]. It was hypothesized that improved tissue perfusion with a device could result in resolution of perioperative "pump failure," allowing later withdrawal of ventricular support.…”

Section: Temporary Clinical Vad Support In Postcardiotomy Patientsmentioning

confidence: 99%

Temporary and permanent left ventricular bypass: Laboratory and clinical observations

et al. 1985

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Temporary circulatory support with a pneumatic, axisymmetric, paracorporeal ventricular assist device (VAD) has been undertaken in 22 postcardiotomy patients. During VAD function, 9 patients demonstrated hemodynamic improvement (group I), and eventually, 8 of these stabilized sufficiently to permit device removal. Three remain alive and well up to 5 years postoperatively. The clinical course of 13 others (group II) was complicated by severe postoperative bleeding and abnormalities in renal function, leading to lack of hemodynamic improvement and death. In group I, the duration of cardiopulmonary bypass (CPB) ranged from 4.3 to 9.0 hr (mean 6.0 hr), and in group II, from 3.7 to 10.0 hr (mean 5.9 hr). The duration of VAD function was 125 hr (mean) in group I, and 25 hr (mean) in group II. Major hematologic abnormalities (secondary to prolonged CPB) included thrombocytopenia, abnormal platelet function studies, severe hypofibrinogenemia, and low levels of fibrinogen/fibrin degradation products. Efforts to develop a permanent, electrically powered ventricular assist system (VAS) for patients with irreversible cardiomyopathy and end‐stage coronary artery disease are also progressing. In a recent series of animal experiments, 2 components of the VAS, an electromechanical energy converter and pusher‐plate blood pump (stroke volume 85 ml) were evaluated (9 calves, 30–149 days). The bloodcontacting surfaces of the device consisted of textured fibrils to attract a fibrin coagulum. Conversion of this layer to a collagenous membrane was achieved by preliminary seeding of the pump with cultured, bovine fetal fibroblasts (5 calves). These were compared with 4 non‐cell‐seeded devices (controls), and functioned for longer periods without thromboembolic complications.

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“…Wie die meisten Assistsysteme befindet sich auch dieses noch in tierexperimenteller Prüfung. Aber es ist gelungen, den Bypass 120 Tage lang pumpend im Tier zu belassen (6,24). Literatur…”

Section: Permanente Unterstützung Des Herzensunclassified

Assistierte Zirkulation^*

Bleifeld¹

1970

Dtsch med Wochenschr

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Die Entwicklung von Assistsystemen zur mechanischen Unterstützung der Herz-und Kreislauftätigkeit hat in der letzten Zeit an Aktualität gewonnen, denn bei einem Teil von akuten und chronischen Herzinsuffizienzen ist mit den bekannteh medikamentösen Maßnahmen keine ausreichende Besserung zu erzielen. Im Mittelpunkt der Überlegungen steht dabei das Ziel, die Funktion des Herzens als Pumpe teilweise oder ganz auf mechanische Pumpsysteme zu übertragen. Isoliertes und kombiniertes Auftreten von Rechts-und Linksinsuffizienzen des Herzens kennzeichnen die Variabilität der Bedingungen, unter denen eine mechanische Kreislaufunterstützung zur Anwendung gelangen kann. Ein einzelnes Assistsystem wird daher nicht jene Flexibilität besitzen, um den verschiedenen klinischen Situationen eines teilweisen oder vollständigen, zeitweisen oder dauernden Herzversagens gerecht zu werden. Besteht die Hoffnung auf Reversibilität einer Herzschwäche, so bedarf es nur einer kurzzeitigen me-

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An implantable left ventricular-aortic assist device

Cited by 28 publications

References 6 publications

Recent Progress on the Vibrating Flow Pump as a Totally Implantable Ventricular Assist Device

Recent Progress on the Vibrating Flow Pump as a Totally Implantable Ventricular Assist Device

Temporary and permanent left ventricular bypass: Laboratory and clinical observations

Assistierte Zirkulation^*

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An implantable left ventricular-aortic assist device

Cited by 28 publications

References 6 publications

Recent Progress on the Vibrating Flow Pump as a Totally Implantable Ventricular Assist Device

Recent Progress on the Vibrating Flow Pump as a Totally Implantable Ventricular Assist Device

Temporary and permanent left ventricular bypass: Laboratory and clinical observations

Assistierte Zirkulation*

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Product

Resources

About

Assistierte Zirkulation^*