An implantable, designed-for-human-use peripheral nerve stimulation and recording system for advanced prosthetics

Abstract

Complex suture prostheses that deliver sensory and position feedback require a more sophisticated integration with the human user. Here a micro-size active implantable system that provides many-degree-of-freedom neural feedback in both sensory stimulation and motor control is shown, as one potential human-use solution in DARPA's HAPTIX program. Various electrical and mechanical challenge and solutions in meeting both sensory /motor performance as well as ISO 14708 FDA-acceptable human use in an aspirin-size active implementation are discussed.

Homecare Robotic Systems for Healthcare 4.0: Visions and Enabling Technologies

“…For one thing, they could be localized to the Central Nervous System (CNS), such as the brain or spinal cord, serving as Brain-Computer Interface (BCI) [102]. For another, electrodes could also be located to a nervous system outside the CNS, a peripheral nervous system for instance, to transmit command signals to the prosthetics [103]. As to BCIs, the three major signal acquisition methods are electroencephalography (EEG) [104], electrocorticography (ECoG) [105], and intracortical electrodes [106], invasiveness and signal resolution increasing simultaneously in turn.…”

Flexible microelectrode array for interfacing with the surface of neural ganglia

“…Rodger et al used a parylene array to record somatosensory evoked potentials from mouse spinal cord, but the electrodes were not suitable for single-unit or multi-unit recording [34]. Polymer substrates serve as better mechanical matches to neural tissue and have been used for insertion into peripheral nerves as intrafascicular recording arrays [35][36][37]. Additionally, the biocompatibility benefits of thin flexible devices will continue to increase their prominence in the field of neurointerfaces, though issues of water intrusion, delamination, and securement will need to be solved for chronic use [38].…”

A Porcine Model of Peripheral Nerve Injury Enabling Ultra-Long Regenerative Distances: Surgical Approach, Recovery Kinetics, and Clinical Relevance

“…It is also possible to avoid complications from multiple invasive procedures by utilizing implantable devices capable of wireless electrical stimulation and recording. 91,92 We found that these methods were sensitive and reliable in permitting the tracking of axonal regeneration and reinnervation over time without the use of multiple invasive procedures. However, as a final measure, compound muscle and nerve action potentials resulting from intraoperative (direct) nerve stimulation were evaluated at the terminal time point.…”