An implantable active microport based on a self-priming high-performance two-stage micropump

Geipel, Andreas; Goldschmidtböing, Frank; Doll, A.; Jantscheff, Peter; Esser, N.; Massing, Ulrich; Woias, Peter

doi:10.1016/j.sna.2007.11.024

Cited by 21 publications

(18 citation statements)

References 11 publications

(12 reference statements)

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“…Over the last two decades, microelectromechanical systems (MEMS) micropumps have been developed for broad biomedical and biological applications (Laser and Santiago 2004). A subset of these pumps address requirements for implantable drug delivery systems including biocompatibility, reliable operation (precise and accurate flow control), low power consumption, low heat generation, large driving force, and compatibility with a large variety of new and conventional drugs (Geipel, Goldschmidtb et al 2008; Tang, Smith et al 2008; Amirouche, Yu et al 2009). However, the emphasis has been on continuous pumping.…”

Section: Introductionmentioning

confidence: 99%

A MEMS electrochemical bellows actuator for fluid metering applications

Sheybani

Gensler

Meng

2012

Biomed Microdevices

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We present a high efficiency wireless MEMS electrochemical bellows actuator capable of rapid and repeatable delivery of boluses for fluid metering and drug delivery applications. Nafion®-coated Pt electrodes were combined with Parylene bellows filled with DI water to form the electrolysis-based actuator. The performance of actuators with several bellows configurations was compared for a range of applied currents (1-10 mA). Up to 75 boluses were delivered with an average pumping flow rate of 114.40 ± 1.63 μL/min. Recombination of gases into water, an important factor in repeatable and reliable actuation, was studied for uncoated and Nafion®-coated actuators. Real-time pressure measurements were conducted and the effects of temperature, physiological back pressure, and drug viscosity on delivery performance were investigated. Lastly, we present wireless powering of the actuator using a class D inductive powering system that allowed for repeatable delivery with less than 2% variation in flow rate values.

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Section: Introductionmentioning

confidence: 99%

A MEMS electrochemical bellows actuator for fluid metering applications

Sheybani

Gensler

Meng

2012

Biomed Microdevices

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“… Relationship between pressure of the delivery head and flow rate for the micropump driven by the conducting polymer soft actuator (‘proposed pump’; circles). This is compared with results of Ling et al 34 (squares), Wu et al 31 (diamonds), Ramirez and Diamond30 (triangles), Santra et al 33 (crosses) and Geipel et al 35 (inverted triangles). …”

Section: Resultsmentioning

confidence: 76%

A micropump driven by a polypyrrole‐based conducting polymer soft actuator

Naka

Fuchiwaki

Tanaka

2010

Polymer International

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Micropumps are essential components of microfluidic systems and biosensing systems. In particular, micropumps used for micro total analysis systems transport fluids at a microflow rate with high precision. Moreover, they are also needed to transport high-viscosity fluids in cases where there are various types of drugs to be transported. Therefore, in order to realize a micropump that can transport solutions at a microflow rate, it is necessary to develop a high-precision microdeformable actuator with a simple mechanism. The conducting polymer soft actuator reported here opens widely and closes completely as a result of electrochemical oxidation and reduction, respectively. The opening and closing movement of the soft actuator, inside which the cation-driven layer is arranged, becomes large because the anion-driven layer that is arranged outside is the predominant driver. We developed a micropump driven by a conducting polymer soft actuator that opens and closes. Although the developed micropump contains no valve, the micropump can transport fluids in one direction without backflow. The newly developed micropump driven by the conducting polymer soft actuator can transport fluids in one direction without backflow by the opening and closing of two soft actuators. Furthermore, a wider range of flow rates and greater maximum delivery heads are obtained using the newly developed micropump. The energy consumption rate of the micropump is markedly lower than those of conventional micropumps.

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“…From the overview of latest articles, there can be seen comparatively many MEMS based silicon type (Dau, et al, 2009, Lemke, et al, 2011, Spieth, et al, 2012, Yoon, et al, 2007 , polymer membrane type (Fang and Tan, 2010, Doll, et al, 2007, Kim, et al, 2008, Liu, et al, 2011, Ni, et al, 2010 , piezo-element type (Geipel, et al, 2008, Herz, et al, 2010, Izzo, et al, 2007, Kang and Auner, 2011, De Lima, et al, 2009, Ogawa, et al, 2009, Tseng, et al, 2013, Wei, et al, 2014 and peristaltic type (Koch, et al, 2009, Cole, et al, 2011, Chia, et al, 2011, Lee, et al, 2012, Nakahara, et al, 2013 micropumps. Nowadays, it must be obvious that MEMS technology is a most powerful tool for realizing micro devices, and the process is often employed to fabricate devices in many researches.…”

Section: Displacement-type Micropumpsmentioning

confidence: 99%

A review on micropumps from the viewpoint of volumetric power density

Yokota

2014

Mechanical Engineering Reviews

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Micropump is one of critical devices in composing high-performance micro-fluid systems like micro hydraulics, fluid-driven micro machines, micro liquid forced cooling of electrical components, µTAS(Micro total analysis systems), LOC(Lab-on a-chip), micro dosing system and so on. A lot of principles are proposed to develop micropumps in these 30 years. At the same time, many review papers on many kinds of micropumps were published in these 20 years, however, in these 8 years there are little review papers on micropumps, particularly from the point of power density view. Here, first, we survey some recent review articles on the progress of micropumps over the past 25 years. Secondly, we attempt to provide the review on latest trend on micropump researches in these 8 years. Finally, we introduce some powerful micropumps as a power source of micro hydraulics. From the point of view that the micropump can be power source as a micro hydraulics, the state of the art micropumps and their power densities are discussed. Much progress has been made, however, with micropumps suitable for primary applications still not available, it seems that this remains a developing and productive area for future research.

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An implantable active microport based on a self-priming high-performance two-stage micropump

Cited by 21 publications

References 11 publications

A MEMS electrochemical bellows actuator for fluid metering applications

A MEMS electrochemical bellows actuator for fluid metering applications

A micropump driven by a polypyrrole‐based conducting polymer soft actuator

A review on micropumps from the viewpoint of volumetric power density

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