An implantable 455-active-electrode 52-channel CMOS neural probe

López, Carolina Mora; Alexandru, Andrei; Mitra, Srinjoy; Welkenhuysen, Marleen; Eberle, Wolfgang; Bartic, Carmen; Puers, Robert; Yazıcıoğlu, Refet Fırat; Gielen, Georges

doi:10.1109/isscc.2013.6487738

Cited by 67 publications

(73 citation statements)

References 7 publications

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“…Local filtering and amplification are necessary at each electrode to limit the thermal noise from the electrode interface (typically the dominant noise source for MEAs) and prevent aliasing under rapid multiplexing of signals. High gain and low output impedance at the pixel-level are desired to relax noise requirements of subsequent signal conditioning stages and to reduce crosstalk and EMI pickup [8]. Traditional neural amplifiers use capacitive coupling to block low frequency electrochemical offsets and capacitive feedback to accurately set the gain across channels [3].…”

Section: B Unit-sensor Designmentioning

confidence: 99%

A 50µm pitch, 1120-channel, 20kHz frame rate microelectrode array for slice recording

Johnson

Peace

Cleland

et al. 2013

2013 IEEE Biomedical Circuits and Systems Conference (BioCAS)

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We present a 1,120 channel active microelectrode array with 50µm pitch recording sites for direct recording of neural slices. Every sensor site has a frontend low noise amplifier and photopixel for correlating optical stimulus with electrical activity. The frontend is AC-coupled and achieves area-efficiency by integrating the large input capacitor and recording electrode directly over the circuitry in conjunction with a single T-capacitor feedback network. Degraded PSRR (63dB) and CMRR (21dB) from the single feedback network are overcome by utilizing a virtual shared reference, improving rejection to 84dB and 66dB, respectively. Despite a small area, the frontend amplifier has an input-referred noise of 4.3µVrms with tunable high-and low-pass corners with very little variation from site-to-site. Experiments from a transgenic mouse olfactory bulb slice are shown. The array was implemented in a standard 180nm CMOS process.

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Section: B Unit-sensor Designmentioning

confidence: 99%

A 50µm pitch, 1120-channel, 20kHz frame rate microelectrode array for slice recording

Johnson

Peace

Cleland

et al. 2013

2013 IEEE Biomedical Circuits and Systems Conference (BioCAS)

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“…A trade-off between the IC die size and functionality is generally required. However, modern circuit designs [77, 92] and IC fabrication technologies [18, 86] have resulted in innovative designs, enabling designers to relax such compromises.…”

Section: Background On Neural Recording Amplifiersmentioning

confidence: 99%

Implantable neurotechnologies: a review of integrated circuit neural amplifiers

Greenwald

et al. 2016

Med Biol Eng Comput

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Neural signal recording is critical in modern day neuroscience research and emerging neural prosthesis programs. Neural recording requires the use of precise, low-noise amplifier systems to acquire and condition the weak neural signals that are transduced through electrode interfaces. Neural amplifiers and amplifier-based systems are available commercially or can be designed in-house and fabricated using integrated circuit (IC) technologies, resulting in very large-scale integration or application-specific integrated circuit solutions. IC-based neural amplifiers are now used to acquire untethered/portable neural recordings, as they meet the requirements of a miniaturized form factor, light weight and low power consumption. Furthermore, such miniaturized and low-power IC neural amplifiers are now being used in emerging implantable neural prosthesis technologies. This review focuses on neural amplifier-based devices and is presented in two interrelated parts. First, neural signal recording is reviewed, and practical challenges are highlighted. Current amplifier designs with increased functionality and performance and without penalties in chip size and power are featured. Second, applications of IC-based neural amplifiers in basic science experiments (e.g., cortical studies using animal models), neural prostheses (e.g., brain/nerve machine interfaces) and treatment of neuronal diseases (e.g., DBS for treatment of epilepsy) are highlighted. The review concludes with future outlooks of this technology and important challenges with regard to neural signal amplification.

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“…If these resistances are sized appropriately, the remaining transfer function is a simple capacitive voltage divider: (2) where is the coupling capacitance between the two plates ( Fig. 4), is the parasitic switch capacitance and is the wiring parasitic capacitance.…”

Section: Plate and Array Designmentioning

confidence: 99%

Capacitive Proximity Communication With Distributed Alignment Sensing for Origami Biomedical Implants

Loh

Emami

2015

IEEE J. Solid-State Circuits

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Origami implant design is a 3D integration technique which addresses size and cost constraints in biomedical implants. This paper presents a capacitive proximity interconnect scheme that enables chip-to-chip communication across folds in the Origami implant, allowing increased flexibility of chip placement and orientation. The capacitive plate array senses link quality and chip-to-chip alignment, and adapts the data rate at each plate accordingly, shutting down poorly-coupled links to save power. Instead of using separate plate arrays for alignment sensing and communication, this interconnect embeds the alignment sensor and transceiver arrays within the same set of plates, so that link quality can be measured at the communications plates directly, thus simplifying their adaptation to alignment. In order to save power and area, the sensor circuitry is distributed across the array and shares functional blocks with the transceiver. Data rates from 10-60 Mbps are achieved over 4-12 µm of parylene-C, with efficiencies up to 0.180 pJ/bit.

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An implantable 455-active-electrode 52-channel CMOS neural probe

Cited by 67 publications

References 7 publications

A 50µm pitch, 1120-channel, 20kHz frame rate microelectrode array for slice recording

A 50µm pitch, 1120-channel, 20kHz frame rate microelectrode array for slice recording

Implantable neurotechnologies: a review of integrated circuit neural amplifiers

Capacitive Proximity Communication With Distributed Alignment Sensing for Origami Biomedical Implants

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An implantable 455-active-electrode 52-channel CMOS neural probe

Cited by 67 publications

References 7 publications

A 50&#x00B5;m pitch, 1120-channel, 20kHz frame rate microelectrode array for slice recording

A 50&#x00B5;m pitch, 1120-channel, 20kHz frame rate microelectrode array for slice recording

Implantable neurotechnologies: a review of integrated circuit neural amplifiers

Capacitive Proximity Communication With Distributed Alignment Sensing for Origami Biomedical Implants

Contact Info

Product

Resources

About

A 50µm pitch, 1120-channel, 20kHz frame rate microelectrode array for slice recording

A 50µm pitch, 1120-channel, 20kHz frame rate microelectrode array for slice recording