An immunotherapeutic approach to decipher the role of long non-coding RNAs in cancer progression, resistance and epigenetic regulation of immune cells

Varier, Krishnapriya M.; Dhandapani, Hemavathi; Liu, Wuling; Song, Jialei; Wang, Chunlin; Hu, Anling; Ben‐David, Yaacov; Shen, Xiangchun; Li, Yanmei; Gajendran, Babu

doi:10.1186/s13046-021-01997-5

Cited by 9 publications

(5 citation statements)

References 166 publications

(123 reference statements)

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“…Upregulation of its expression can increase anti-tumor response. It is indicated that GAS5 has a role in increased NK cell cytotoxicity and that it is also involved in initiation and phagophore nucleation [ 40 ]. All of this shows that GAS5 could potentially be an important therapeutic target in AML as well.…”

Section: Discussionmentioning

confidence: 99%

Expression Profiles of Long Non-Coding RNA GAS5 and MicroRNA-222 in Younger AML Patients

et al. 2021

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Acute myeloid leukemia (AML) is a heterogeneous malignant disease both on clinical and genetic levels. AML has poor prognosis and, therefore, there is a constant need to find new prognostic markers, as well as markers that can be used as targets for innovative therapeutics. Recently, the search for new biomarkers has turned researchers’ attention towards non-coding RNAs, especially long non-coding RNAs (lncRNAs) and micro RNAs (miRNAs). We investigated the expression level of growth arrest-specific transcript 5 (GAS5) lncRNA in 94 younger AML patients, and also the expression level of miR-222 in a cohort of 39 AML patients with normal karyotype (AML-NK), in order to examine their prognostic potential. Our results showed that GAS5 expression level in AML patients was lower compared to healthy controls. Lower GAS5 expression on diagnosis was related to an adverse prognosis. In the AML-NK group patients had higher expression of miR-222 compared to healthy controls. A synergistic effect of GAS5low/miR-222high status on disease prognosis was not established. This is the first study focused on examining the GAS5 and miR-222 expression pattern in AML patients. Its initial findings indicate the need for further investigation of these two non-coding RNAs, their potential roles in leukemogenesis, and the prognosis of AML patients.

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Section: Discussionmentioning

confidence: 99%

Expression Profiles of Long Non-Coding RNA GAS5 and MicroRNA-222 in Younger AML Patients

et al. 2021

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“…Of these 13, 6 genes (RNF10, IFFO2, SLC17A5, UBXN2B, ZNF117, and ZNF488) have previous links to neurodegenerative diseases, while IFFO2 participates in muscle control [43][44][45][46][47][48] and 5 other genes (CECR7, STMP1, TRAF31P2-AS1, and LOC401127) [49][50][51][52] have roles in in ammation, bone, and autoimmune diseases. The remaining two genes -CEP78 and NUDT18 -encode for a centrosomal protein and a hydrolase of the Nudix superfamily, respectively.…”

Section: Meta-analysis Of Dge In Neurologic Tissuementioning

confidence: 99%

A deep transcriptome meta-analysis reveals sex differences in multiple sclerosis

Català-Senent¹,

Andreu²,

Hidalgo³

et al. 2023

Neurobiology of Disease

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“…In nervous tissue, our meta-analysis detected 13 significant genes in the SDID comparison (Table 6). Of these 13, 6 genes (RNF10, IFFO2, SLC17A5, UBXN2B, ZNF117, and ZNF488) have previous links to neurodegenerative diseases, while IFFO2 participates in muscle control [43][44][45][46][47][48] and 5 other genes (CECR7, STMP1, TRAF31P2-AS1, and LOC401127) [49][50][51][52] possess links to inflammation, bone, and autoimmune diseases. The remaining two genes -CEP78 and NUDT18 -encode for a centrosomal protein and a hydrolase of the Nudix superfamily, respectively.…”

Section: Meta-analysis Of Dge In Nervous Tissuementioning

confidence: 99%

A Deep Transcriptome Meta-Analysis Reveals Sex-based Molecular Differences in Multiple Sclerosis

Català-Senent

Andreu

Roig

et al. 2021

Preprint

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Background: Multiple Sclerosis (MS) is a chronic autoimmune, inflammatory, and degenerative disease of the central nervous system that affects both women and men but the risk of developing MS is higher in women (2-3:1 ratio compared to men). Current knowledge does not allow a precise definition of the sex-related factors intervening in MS. Here, we explore the role of sex in this neurodenegerative disease to identify molecular mechanisms underlying sex-based diferences that can guide novel therapeutics approaches aimed for men and women. Methods: We performed a rigorous and systematic review of MS whole transcriptome studies that included sex patient information in Gene Expression Omnibus and ArrayExpress databases, following PRISMA statment guidelines. A differential gene expression (DGE) was performed for each selected study. Then, three meta-analyses based on genes and different contrasts were addressed to evaluate common features and sex bias in all scenarios: one meta-analysis in nervous tissue studies (4), another in blood studies (5), and a third that integrated the studies from both tissues, blood and nervous system (9). Finally, a gene set analysis (GSA) was performed on the meta-analyzed differential transcriptomic profile between women and men, to study their involvement in biological pathways and phenotypes (physiological and pathological states) sex related. Results: After screening 122 publications, the systematic review provided a selection of nine studies (5 in blood and 4 in nervous tissue) with a total of 653 samples (269 MS women, 152 control women, 116 MS men, 116 control men). The blood sex-differences gene meta-analysis identified 1 gene overexpressed in women (KIR2DL3) while gene meta-analysis in the nervous tissue resulted in 5 genes differentially expressed (4 overexpressed in women: C7orf73, CECR7, TRAF3IP2-AS1, ZNF117; and 1 overexpressed in men: HIST1H2AE). In the global meta-analysis (blood and nervous tissue), 1 gene involved in sex differences were detected (more expressed in women: LOC102723701). 9 MS biomarkers were also identified in both sexes (4 overexpressed genes in MS patients: HIST1H2BC, SMEK2, STBD1, TMEM140) and 5 down-regulated in MS patients: C16orf59, C20orf177, C9orf23, FAM65B, PKI55). Additionally, the GSA related to gene meta-analysis revealed a set of functions differentially enriched in men and women, in the different analysed tissues. Conclusion: These findings provide valuable opportunities for better understanding of MS related sex differences and develop effective and sex-specific interventions down further studies.

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An immunotherapeutic approach to decipher the role of long non-coding RNAs in cancer progression, resistance and epigenetic regulation of immune cells

Cited by 9 publications

References 166 publications

Expression Profiles of Long Non-Coding RNA GAS5 and MicroRNA-222 in Younger AML Patients

Expression Profiles of Long Non-Coding RNA GAS5 and MicroRNA-222 in Younger AML Patients

A deep transcriptome meta-analysis reveals sex differences in multiple sclerosis

A Deep Transcriptome Meta-Analysis Reveals Sex-based Molecular Differences in Multiple Sclerosis

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