An Immunohistochemical Study of Type I Insulin-like Growth Factor Receptors in the Placentae of Pregnancies with Appropriately Grown or Growth Restricted Fetuses

Holmes, Robert; Porter, Helen; Newcomb, Paul V.; Holly, J.M.P.; Soothill, P. W.

doi:10.1053/plac.1998.0387

Cited by 39 publications

(29 citation statements)

References 29 publications

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“…Increased IGF-1R protein expression in our study contradicts data published for human IUGR [53]. Our data do agree with findings of Abu-Amero et al [43] who reported that with IUGR the term placentae displayed higher levels of IGF2 and IGF1R expression compared with the normal term placentae.…”

Section: Igf Receptorssupporting

confidence: 80%

The IGF Axis in Baboon Pregnancy: Placental and Systemic Responses to Feeding 70% Global Ad Libitum Diet

Li¹,

Levitz²,

Hubbard³

et al. 2007

Placenta

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Information on the influence of poor maternal nutrition on the regulation of responses to pregnancy, placental and fetal growth and development is critical to a better understanding of pregnancy physiology and pathophysiology. We determined normal changes and effects of controlled and monitored moderate nutrient restriction (NR) (global nutrient intake reduced to 70% of food consumed by mothers feeding ad libitum from 0.16 to 0.5 of gestation) in the baboon, on important hematological, biochemical, and hormonal indices of fetal growth and placental function. Serum IGF-I:IGFBP-3 ratio was lower in pregnant than control non-pregnant baboons feeding ad libitum. Serum concentrations of total and free IGF-I were decreased in NR mothers compared with controls (p < 0.05). The decrease in fetal IGF-I did not reach significance (p = 0.057). Serum IGF-I: IGFBP-3 ratio was decreased by NR in both mothers and fetuses. Maternal serum IGF-II was unchanged by NR. Placental IGF-I mRNA and protein abundance were similarly reduced whereas IGF-II mRNA increased in placental tissue of NR compared to control mothers. Systemic (maternal) and local (placental) IGFBP-1 and IGFBP-3 mRNA and protein abundance were unchanged by NR. Type 1 IGF receptor protein in the syncytiotrophoblast increased in NR. Type 2 IGF receptor protein was present in the stem villi core, and decreased after NR. We conclude that moderate NR in this important non-human primate model significantly disrupts the maternal and placental IGF-IGFBP axis and influences placental expression of this key system at the gene and protein level. Changes observed appear to be directed toward preserving placental growth.

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Section: Igf Receptorssupporting

confidence: 80%

The IGF Axis in Baboon Pregnancy: Placental and Systemic Responses to Feeding 70% Global Ad Libitum Diet

Li¹,

Levitz²,

Hubbard³

et al. 2007

Placenta

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“…In agreement, Nissen et al (2005) increased feed allocation from days 25 to 50 or days 25 to 70 of gestation with resultant increases in maternal IGF-1 concentrations. IGF-1 does not cross the placental barrier (Davenport et al, 1990;Holmes et al, 1999). The lower maternal IGF-1 observed in restricted gilts in the current study did not result in subsequently lower IGF-1 concentrations in offspring.…”

Section: Discussioncontrasting

confidence: 44%

Maternal backfat depth in gestating sows has a greater influence on offspring growth and carcass lean yield than maternal feed allocation during gestation

Amdi

Giblin

Ryan

et al. 2014

Animal

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A commercial pig spends nearly half of its life in utero and its nutrition during this time can influence birth weight and postnatal growth. We hypothesised that postnatal growth is increased in pigs raised by sows with a high backfat depth and high level of energy intake during gestation compared with sows with a low backfat depth and low level of energy intake during gestation. This was tested in a 2 × 3 factorial design experiment with 2 factors for gilt backfat depth (Thin and Fat) and 3 factors for gestation feed allowance (Restricted, Control and High). Between d 25 and d 90 of gestation, Thin gilts (n = 68; 12 ± 0.6 mm P2 backfat) and Fat gilts ( n = 72; 19 ± 0.6 mm P2 backfat) were randomly allocated, as individuals, to a gestation diet (6.19 g/kg lysine, 13.0 MJ DE/kg) at the following feed allowances: 1.8 kg/day (Restricted); 2.5 kg/day (Control) and 3.5 kg/day (High). For the remainder of gestation and during lactation all gilts were treated similarly. At weaning (day 28), 155 piglets were sacrificed and 272 were individually housed and followed through to slaughter (day 158). At day 80 of gestation, fasted Thin Restricted gilts had lower serum IGF-1 concentrations than Thin High or Thin Control fed gilts ( P < 0.001). Pigs born from Fat gilts had greater backfat depths ( P < 0.05), a lower lean meat yield ( P < 0.05) and were heavier ( P < 0.05) at slaughter than pigs born from Thin gilts. Gilt gestation feed allowance had only transitory effects on average daily gain and feed conversion efficiency and had no effect on pig weight at slaughter ( P > 0.05) or lean meat yield ( P > 0.05). In conclusion, gilts with a backfat depth of~19 mm at insemination produced pigs that were heavier and fatter at~158 days of age than those born from gilts with~12 mm backfat depth at insemination. Maternal body condition during gestation had a more predominant influence on growth parameters of the offspring, such as weight at slaughter and backfat depth, than did feed level during gestation.

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“…The documentation of higher cord blood levels of IGF-1 among Caucasian compared with Asian newborns is concordant with the higher incidence of breast cancer in western compared with eastern Asian populations (Ferlay et al, 2004) and compatible with the role IGF appears to play in breast cancer, at least among premenopausal women (Renehan et al, 2004;Schernhammer et al, 2005). Of note, IGF-1 does not cross the placenta (Holmes et al, 1999) and this was also supported by our data, in which the correlation coefficients Table 2 Percent differences a of cord blood levels of IGF-1, IGF-2, and IGFBP-3 between newborns in Boston, USA (reference) and Shanghai, China IGF ¼ insulin-like growth factor. a Adjusted for maternal age, height and weight gain, parity, duration of gestation, and gender of offspring.…”

Section: Discussionsupporting

confidence: 54%

“…We hypothesised, therefore, that cord blood levels of IGF-1, which does not cross the placenta (Holmes et al, 1999), are higher among Caucasian than among Asian neonates, and that cord blood IGF-1 levels are positively associated with birth size. We evaluated this hypothesis, and also examined the role of IGF-2, a main component of the IGF system in foetal life, by studying cord blood samples from babies born to women in Boston, USA and Shanghai, China.…”

mentioning

confidence: 99%

Insulin-like growth factor levels in cord blood, birth weight and breast cancer risk

et al. 2009

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Breast cancer incidence and birth weight are higher among Caucasian than Asian women, and birth size has been positively associated with breast cancer risk. Pregnancy hormone levels, however, have been generally lower in Caucasian than Asian women. We studied components of the insulin-like growth factor (IGF) system in cord blood from 92 singleton babies born in Boston, USA, and 110 born in Shanghai, China, in 1994-1995. Cord blood IGF-1 was significantly higher among Caucasian compared with Chinese babies (Po10 À6 ). The opposite was noted for IGF-2 (PB10 À4 ). IGF-1 was significantly positively associated with birth weight and birth length in Boston, but not Shanghai. In contrast, stronger positive, though statistically non-significant, associations of IGF-2 with birth size were only evident in Shanghai. The associations of birth weight and birth length were positive and significant in taller women (for IGF-1 in Boston PB0.003 and 0.03, respectively; for IGF-2 in Shanghai PB0.05 and B0.04, respectively), among whom maternal anthropometry does not exercise strong constraints in foetal growth. The documentation of higher cord blood levels of IGF-1, a principal growth hormone that does not cross the placenta, among Caucasian than in Asian newborns is concordant with breast cancer incidence in these populations.

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An Immunohistochemical Study of Type I Insulin-like Growth Factor Receptors in the Placentae of Pregnancies with Appropriately Grown or Growth Restricted Fetuses

Cited by 39 publications

References 29 publications

The IGF Axis in Baboon Pregnancy: Placental and Systemic Responses to Feeding 70% Global Ad Libitum Diet

The IGF Axis in Baboon Pregnancy: Placental and Systemic Responses to Feeding 70% Global Ad Libitum Diet

Maternal backfat depth in gestating sows has a greater influence on offspring growth and carcass lean yield than maternal feed allocation during gestation

Insulin-like growth factor levels in cord blood, birth weight and breast cancer risk

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