An immunohistochemical study of the origin of the solid strand in syringoma, using carcinoembryonic antigen, epithelial membrane antigen, and cytokeratin 5

Kim, Byung Chul; Park, Eun Joo; Kwon, In Ho; Cho, Hee Jin; Park, Hye Rim; Kim, Kwang Ho

doi:10.1111/j.1365-4632.2011.05069.x

Cited by 3 publications

(1 citation statement)

References 24 publications

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“…Immunohistological investigations suggest an eccrine duct origin [6] . The solid strands seem to originate from the outer cells of the lower epidermal duct or the transitional portion between the intraepidermal duct and dermal duct in the normal eccrine gland [7] .…”

Section: Introductionmentioning

confidence: 99%

Periocular syringomas – Successful treatment with fractional CO2 laser

Goldman

Wollina²

2017

J Surg Dermatol

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Syringoma is a benign tumor of eccrine origin which arises from eccrine ducts. Syringomas are most commonly found on the eyelids in middle-aged women. Traditional treatments include surgical excision, curettage, peelings, dermabrasion and laser. We report on the successful use of fractional laser on periocular syringomas. A 53-year-old female patient with multiple periorbital syringomas underwent three sessions of fractional carbon dioxide (CO 2 ) laser. Settings of 20 watts of power, 600 μm of spacing, 800 μs of dwell, time stack 2 (Smartxide DOT, DEKA, Florence, Italy) were used. The sessions were performed monthly. Significant improvement of the esthetic appearance was observed after three sessions. There was a decrease of visible syringomas associated with an evident improvement of the skin texture, skin quality and flaccidity. No side effects were observed. We suggested continuing the treatment but the patient was satisfied with the current aspect and result. In conclusion, fractional CO 2 laser represents an effective treatment option for the treatment of periorbital syringomas.

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Section: Introductionmentioning

confidence: 99%

Periocular syringomas – Successful treatment with fractional CO2 laser

Goldman

Wollina²

2017

J Surg Dermatol

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Lesions of Anogenital Mammary-Like Glands, Adnexal Neoplasms, and Metastases

Hoang

Kazakov

2014

Vulvar Pathology

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Engrailed Homeobox 1 and Cytokeratin 19 Are Independent Diagnostic Markers of Eccrine Porocarcinoma and Distinguish It From Squamous Cell Carcinoma

Miura¹,

Akashi

Namiki

et al. 2020

American Journal of Clinical Pathology

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Objectives The diagnostic utility of En1 in the histopathologic differentiation of eccrine porocarcinoma (EPC) from invasive squamous cell carcinoma (SCC) was investigated. Methods Expression of En1 and CK19 in 16 cases of EPC was immunohistochemically examined and compared with that in 32 cases of SCC. Results In all 16 EPCs, En1 was expressed in 3% to 100% of tumor cells. In 20 of the 32 SCCs, En1 was expressed in 3% to 90% of tumor cells. A total of 13 of the 16 EPCs and five of the 32 SCCs were judged as En1 positive, with a cutoff value of 25%. In addition, 11 of the 16 EPCs and four of the 32 SCCs were CK19 positive. The frequencies of En1- and CK19-positive cases were significantly higher in EPCs than in SCCs. In a logistic regression analysis for predicting EPC, En1 and CK19 were independent markers. When expression patterns of En1 and CK19 were combined, none of the 32 SCCs was both positive. In contrast, 15 of the 16 EPCs were positive for either En1 or CK19. Conclusions A combination of En1 and CK19 expression can improve the accuracy of histologic diagnosis of EPC.

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An immunohistochemical study of the origin of the solid strand in syringoma, using carcinoembryonic antigen, epithelial membrane antigen, and cytokeratin 5

Cited by 3 publications

References 24 publications

Periocular syringomas – Successful treatment with fractional CO2 laser

Periocular syringomas – Successful treatment with fractional CO2 laser

Lesions of Anogenital Mammary-Like Glands, Adnexal Neoplasms, and Metastases

Engrailed Homeobox 1 and Cytokeratin 19 Are Independent Diagnostic Markers of Eccrine Porocarcinoma and Distinguish It From Squamous Cell Carcinoma

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