An immunohistochemical study of canine spontaneous gastric polyps

Amorim, Irina; Taulescu, Marian; Ferreira, Andreia; Rêma, Alexandra; Reis, Celso A.; Faustino, Augusto; Cătoi, C.; Gärtner, Fátima

doi:10.1186/s13000-014-0166-z

Cited by 13 publications

(14 citation statements)

References 20 publications

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“…That is, the results of Tn and STn immunoexpression recorded in canine GPs were very similar to those obtained in the normal canine gastric mucosa. These evidences reinforce previous results achieved by our group, which concluded that canine GPs do not present relevant molecular alterations, thus should be considered merely proliferative and hyperplastic lesions, with lack of features suggestive of neoplastic transformation 23 …”

Section: Discussionsupporting

confidence: 91%

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Tn and Sialyl‐Tn antigens in canine gastric tissues

Flores

Lemos

Rêma

et al. 2020

Vet Comparative Oncology

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Malignant transformation is often associated with abnormal protein glycosylation expressed, amongst others, by the accumulation of simple mucin-type carbohydrates namely Tn and Sialyl-Tn (STn) antigens. These are usually limited in normal tissues and their increased expression has been associated with cancer progression and poor prognosis. This study aims to evaluate the role of Tn and STn antigens in the neoplastic transformation of the canine gastric mucosa and to correlate their putative immunoexpression alterations with some pathological features. Tn and STn antigens expression were immunohistochemically evaluated in canine normal gastric mucosa (n = 3), gastric polyps (n = 9) and gastric carcinomas (n = 25), neoplastic emboli (n = 12) and metastases (n = 8). In normal gastric mucosa, Tn antigen was detected in the gastric epithelial cells, while STn antigen was absent. Similarly, all gastric polyps expressed Tn antigen, but none displayed STn antigen immunostaining. In carcinomas, Tn antigen was expressed in 96% of the cases and STn antigen in 68% of the neoplasms. STn antigen was significantly higher in carcinomas compared with normal mucosa (P < .05). No correlation was found between each antigen and the different subtypes of tumours according to WHO classification, tumour differentiation, lymph vascular invasion or metastasis. All neoplastic emboli expressed both antigens, and the expression score was similar or higher than that displayed by the neoplastic cells of the primary tumour. The high prevalence of STn antigen in gastric carcinomas compared with normal mucosa highlights the cancer-associated nature of this antigen. Our results link STn antigen expression to neoplastic transformation and suggest that it may be a useful marker of gastric cancer progression in dogs.

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Section: Discussionsupporting

confidence: 91%

“…Gastric polyps (GPs) are incidental findings in both human and dogs 19,20 . A previous study conducted by our group demonstrated that unlike in humans, 21,22 canine GPs do not display some molecular features suggestive of malignant transformation 23 …”

Section: Introductionmentioning

confidence: 78%

Tn and Sialyl‐Tn antigens in canine gastric tissues

Flores

Lemos

Rêma

et al. 2020

Vet Comparative Oncology

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“…In these dogs, hypergastrinaemia secondary to atrophy may be important in carcinogenesis . Unlike in humans, precursor lesions are not frequently described in dogs that develop GC and no convincing relationship could be demonstrated between gastric polyps that are sporadically identified, Helicobacter , and GC . H .…”

Section: Introductionmentioning

confidence: 88%

Gastric carcinoma in canines and humans, a review

Hugen

Thomas

German

et al. 2016

Vet Comparative Oncology

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Gastric carcinoma (GC) is the most common neoplasm in the stomach of dogs. Although incidence in the general population is reported to be low, breed-specific GC has a high incidence. Median age at presentation ranges from 8 to approximately 10 years. The disease is mostly located in the lesser curvature and antropyloric region of the stomach. Unfortunately, diagnosis is usually made when the disease is at an advanced stage and, therefore, prognosis is poor. Due to similarities in clinical presentation, diagnosis, histology and prognosis, canine GC may serve as a valuable model for human GC. Extensive pedigrees of canine gastric carcinoma cases could reveal insights for human gastric carcinoma. Putative species differences include the role of Helicobacter in pathogenesis, the wide array of genetic data and screening available for humans, and treatment protocols that are available for human GC.

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“…3,4 Reported tumors include adenocarcinomas, leiomyosarcomas, lymphomas, leiomyomas, polyps, adenomas, gastrointestinal stromal tumor, plasmocytoma, mast cell, and fibrosarcoma. 2,[5][6][7][8][9] In veterinary medicine, standard imaging modalities used to characterize and stage gastric masses include radiography, ultrasonography, and endoscopy. 9,10 On radiography, gastric masses may be recognizable if the stomach is filled with air.…”

Section: Introductionmentioning

confidence: 99%

Contrast‐enhanced computed tomography may be helpful for characterizing and staging canine gastric tumors

Tanaka

Akiyoshi

Mie

et al. 2018

Vet Radiology Ultrasound

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In humans, computed tomography (CT) is a widely performed technique for the diagnosis and staging of gastric tumors. The purpose of this retrospective case series study was to describe CT findings in a group of dogs with confirmed gastric tumors. For each included dog, the following CT parameters were recorded: gastric tumor location, tumor shape, gastric involvement pattern, tumor enhancement pattern in early and late phases, presence and location of lymphadenopathy, gastric tumor attenuation values, attenuation values of enlarged lymph nodes, maximum short-axis diameter (mm) of enlarged lymph node, maximum long-axis diameter (mm) of enlarged lymph node, and short-axis diameter to long-axis diameter ratio (short axis/long axis). A total of 16 dogs met inclusion criteria and had the following final diagnoses: five lymphoma, six adenocarcinoma, three inflammatory polyps, and two leiomyoma. In the early- and delayed-phase postcontrast images, the mean CT attenuation value for lymphoma was lower than that of other gastric tumors. Lymphadenopathy was widespread in lymphomas and regional in adenocarcinomas. Lymphadenopathy was not detected in leiomyomas. Lymph node measurements in lymphoma were larger than lymph node measurements in adenocarcinoma. Although there were overlapping findings for the different types of gastric tumors, contrast-enhanced CT provided helpful information for characterizing gastric tumors based on the following criteria: early and late enhancement patterns, the site of origin of the mass lesion, and extent of local invasion and distant metastases. Lymphoma should be considered for canine gastric tumors with low mean attenuation values during early- and delayed-phase postcontrast images, and widespread, bulky, and rounded lymphadenopathy.

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An immunohistochemical study of canine spontaneous gastric polyps

Cited by 13 publications

References 20 publications

Tn and Sialyl‐Tn antigens in canine gastric tissues

Tn and Sialyl‐Tn antigens in canine gastric tissues

Gastric carcinoma in canines and humans, a review

Contrast‐enhanced computed tomography may be helpful for characterizing and staging canine gastric tumors

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