An immunohistochemical study of a lympithelial cyst occurring on the ventral surface of the tongue.

Yamamoto, Hirotsugu; Fukumoto, Masahiko; Matsumoto, Takashi; Gunge, Masahiko; Otake, Shigeo

doi:10.2334/josnusd1959.29.206

Cited by 3 publications

(1 citation statement)

References 7 publications

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“…In most cases LECs are clinically misdiagnosed as mucus cyst ( 9 , 18 - 20 , 36 , 37 , 46 , 48 , 51 - 53 ), with the list of clinical diagnoses also including normal anatomic structures, such as foliate papilla, sebaceous gland, sublingual gland or lymphoid tissue ( 18 , 20 , 36 , 50 , 53 ), as well as pathological entities, including lipoma, fibroma, inflammatory fibrous hyperplasia, squamous papi-lloma, granular cell tumor, dermoid cyst, inclusion cyst, abscess, sialolithiasis, sialadenitis, nevus and leukoplakia ( 8 , 18 , 20 , 35 , 36 , 38 , 48 - 50 , 53 ). The high accuracy of clinical diagnosis in the present study may be associated with the location of all cases in typical anatomical sites, e.g.…”

Section: Discussionmentioning

confidence: 99%

Oral lymphoepithelial cyst: A clinicopathological study of 26 cases and review of the literature

et al. 2017

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IntroductionΤo describe the clinicopathological features of 26 oral lymphoepithelial cysts (LECs) and review the literature.Material and MethodsTwenty-six cases of oral LECs diagnosed during a 37-year period were retrospectively collected. The patients’ gender and age, as well as the main clinical features of the cysts were retrieved from the requisition forms. The main microscopic features were recorded after reevaluation of all cases. Pubmed and Google Scholar electronic databases were searched with the key word “oral LEC”. Inclusion criteria were the microscopic confirmation of LEC diagnosis and the report at least two of three main clinical features (gender, age and cyst’s location).ResultsThe 26 oral LECs represented 0.08% of 31,564 biopsies accessioned during the study period. They affected 25 patients, 14 females and 11 males with a mean age of 33.04±9.81 years. They appeared as smooth (92%) nodules, with soft (24%) or firm (76%) consistency and normal (28%), yellow to normal (20%), yellow (32%) or white (20%) hue, in the tongue (69.23%) or the floor of mouth (30.77%). They were covered by parakeratinized squamous (92.31%) or non-keratinized (7.69%) epithelium and contained desquamated epithelial cells, amorphous eosinophilic material and/or inflammatory cells (100%). The lymphoid tissue surrounded the cystic cavity partially (34.62%) or completely (65.38%), often in a follicular pattern with prominent germinal centers (53.85%). Literature review yielded 316 cases of oral LECs derived from 25 case reports, 3 case studies/retrospective studies with detailed information for each case and 7 studies with summarized data.ConclusionsOral LEC is a pathologic entity with discrete clinical presentation that is, however, commonly misdiagnosed in clinical practice as other, mostly benign, entities. Its pathogenesis remains obscure, as its clinicopathologic features are consistent with both theories suggested up to date. Key words:Oral lymphoepithelial cyst; developmental cyst; non odontogenic cyst; lymphoid tissue; oral tonsil.

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Section: Discussionmentioning

confidence: 99%

Oral lymphoepithelial cyst: A clinicopathological study of 26 cases and review of the literature

et al. 2017

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A Retrospective Clinico-Pathological Analysis with Review of Literature of Oral and Cervical Lympho-Epithelial Cysts from a Pathological Perspective

et al. 2022

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Oral and cervical lympho-epthelial cysts (LECs) are uncommon lesions with histopathological similarities. The aim of the study is to present clinico-pathological characteristics of oral and cervical LECs with a review of literature in order to create awareness on this uncommon entity. Eighteen new cases of oral and cervical LECs obtained from the archives of the University of Peradeniya and University of Geneva were used for the clinico-pathological analysis. The average age at diagnosis of 7 oral and 11 cervical LECs were 40 and 36 years, respectively. Both showed a female predilection (male:female ratio at 3:4 and 4:7, respectively). The only difference was found in the size of the lesions with oral LECs being significantly smaller than cervical LECs (0.9 cm vs. 4.6 cm). LECs may clinically resemble neoplasms (4/18), including malignancies (1/11 in the present series). None of the 18 LECs recurred following surgical removal. The literature-review-based analysis of 514 oral LECs confirms that the lesions are observed predominantly in adults in 4th–5th decades of life and are relatively small lesions of less than 2 cm in diameter. Oral LECs were found to occur predominantly in the tongue and floor of the mouth, similar to 88% of lesions in literature. In conclusion, oral and cervical LECs are two histologically similar cysts that occur in two distinct sites. The literature review supports the information observed in our study with respect to age of occurrence, site predilections, and size. Cervical LECs, particularly the ones that occur in the parotid region, may require further investigations to exclude BLEL of parotid gland, which occur in HIV infected patients.

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The two cases of lymphoepithelial cysts in the ventral surface of the tongue. Immunohistochemical studies.

Kasai

Kurenuma

Sato

et al. 1991

Jpn. J. Oral Maxillofac. Surg.

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An immunohistochemical study of a lympithelial cyst occurring on the ventral surface of the tongue.

Cited by 3 publications

References 7 publications

Oral lymphoepithelial cyst: A clinicopathological study of 26 cases and review of the literature

Oral lymphoepithelial cyst: A clinicopathological study of 26 cases and review of the literature

A Retrospective Clinico-Pathological Analysis with Review of Literature of Oral and Cervical Lympho-Epithelial Cysts from a Pathological Perspective

The two cases of lymphoepithelial cysts in the ventral surface of the tongue. Immunohistochemical studies.

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