An immunohistochemical comparison of cytokeratin 7, cytokeratin 15, cytokeratin 19, CAM 5.2, carcinoembryonic antigen, and nestin in differentiating porocarcinoma from squamous cell carcinoma

Mahalingam, Meera; Richards, Joanna E.; Selim, M. Angélica; Muzikansky, Alona; Hoang, Mai P.

doi:10.1016/j.humpath.2011.10.005

Cited by 45 publications

(62 citation statements)

References 38 publications

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“…In terms of clinical course, although the gross size of the tumor has no significant relationship to prognosis, other characteristics such as multinodularity, ulceration, and rapid growth may be associated with local recurrence or metastasis. 41 When the above histological high-risk factors are present, sentinel lymph node biopsy may be considered, although its benefits are still unclear. Infiltrative subtype or pattern has been shown to correlate with local recurrence.…”

Section: Clinical Presentationmentioning

confidence: 99%

Mohs Micrographic Surgery for Eccrine Porocarcinoma

Song

Lee

Hamman

et al. 2015

Dermatologic Surgery

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Section: Clinical Presentationmentioning

confidence: 99%

Mohs Micrographic Surgery for Eccrine Porocarcinoma

Song

Lee

Hamman

et al. 2015

Dermatologic Surgery

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“…Current immune histological markers reported to be helpful include CEA and EMA as the most sensitive ones and cytokeratin 19 as the most specific one (6). Differentiation of squamous variants of eccrine porocarcinoma from SCC is particularly challenging (7), but essential because porocarcinomas have a greater propensity for developing lymph node metastases and a poorer survival (4,6). Lymphatic metastasis occurs in 10-20% of cases regardless of the tumour thickness (3,6).…”

Section: Department Of Dermatology University Of Heidelberg De-6912mentioning

confidence: 99%

“…Differentiation of squamous variants of eccrine porocarcinoma from SCC is particularly challenging (7), but essential because porocarcinomas have a greater propensity for developing lymph node metastases and a poorer survival (4,6). Lymphatic metastasis occurs in 10-20% of cases regardless of the tumour thickness (3,6). While visceral metastases are rare, the case facility rate in patients with lymph node metastases is approximately 67% (8).…”

Section: Department Of Dermatology University Of Heidelberg De-6912mentioning

confidence: 99%

Zosteriform Metastases of Eccrine Porocarcinoma Mimicking Eruptive Seborrhoeic Keratoses

Müller¹,

Zschoche²,

Hartschuh³

et al. 2015

Acta Derm Venerol

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“…[83][84][85][86] The main histologic mimic is squamous cell carcinoma, and a panel of cytokeratin 19 and cytokeratin 7 is considered helpful. 87 Regarding molecular studies, TP53 and PIK3CA mutations and EGFR gene polysomy have been documented in rare cases of porocarcinomas. 78,79,81 Eccrine Carcinoma.-The overlapping features of eccrine carcinoma and adenocarcinoma of mammary-like glands make this distinction challenging.…”

mentioning

confidence: 99%

Vulvar Adnexal Lesions: A 32-Year, Single-Institution Review From Massachusetts General Hospital

Baker

Selim

Hoang

2013

Archives of Pathology &Amp; Laboratory Medicine

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Context.-Because the skin and modified mucosal surfaces of the vulvar region contain dense apocrine glands and anogenital mammary-like glands, in addition to eccrine glands and folliculosebaceous units, benign as well as malignant lesions derived from these adnexal structures are, not surprisingly, found in the vulva. However, their incidence occurring in the vulva has not been reported, to our knowledge.Objective.-To determine the incidence of various vulvar adnexal lesions.Design.-We performed a retrospective review of the cases at our institution.Results.-A total of 189 vulvar adnexal lesions were identified. Most of these lesions were benign (133 of 189; 70%), with hidradenoma papilliferum being the most common, followed by syringoma and various types of cysts. Rare cases of tubular adenoma, poroma, spiradenoma, hidradenoma, cylindroma, sebaceoma, and trichoepithelioma were identified. Malignant adnexal neoplasms comprised the remaining 30% (56 of 189) of the cases. Extramammary Paget disease was the most common (49 of 56), and 29% (14 of 49) demonstrated an invasive component. Rare cases of basal cell carcinoma, sebaceous carcinoma, apocrine carcinoma, adenoid cystic carcinoma, and spiradenocarcinoma were identified.Conclusions.-In this retrospective review, we identified several benign entities that have not been previously reported on the vulva, namely pilomatricoma, poroma, spiradenoma, and sebaceoma. Hidradenoma papilliferum and extramammary Paget disease were the most common benign and malignant adnexal neoplasms, respectively. The spectrum of various vulvar adnexal lesions appears to reflect the frequency of the underlying glandular elements.

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An immunohistochemical comparison of cytokeratin 7, cytokeratin 15, cytokeratin 19, CAM 5.2, carcinoembryonic antigen, and nestin in differentiating porocarcinoma from squamous cell carcinoma

Cited by 45 publications

References 38 publications

Mohs Micrographic Surgery for Eccrine Porocarcinoma

Mohs Micrographic Surgery for Eccrine Porocarcinoma

Zosteriform Metastases of Eccrine Porocarcinoma Mimicking Eruptive Seborrhoeic Keratoses

Vulvar Adnexal Lesions: A 32-Year, Single-Institution Review From Massachusetts General Hospital

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