An Immunofluorescence Study on Intracellular Immunoglobulins in Human Bone Marrow Cells

Hijmans, W.; Schuit, H. R. E.; Hulsing-Hesselink, E.

doi:10.1111/j.1749-6632.1971.tb35059.x

Cited by 94 publications

(26 citation statements)

References 8 publications

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“…The cytoplasmic heavy figure 1 [19]. The percentage distribution of BM cells with intracellular heavy and light chains shown in table I is similar to values reported earlier for BM [4,15] and comparable to values ob served in spleen and tonsils [2,3,10,15]. It is known that molecules of the various Ig classes differ in their rate of catabolism and in the distribu tion within body compartments [18].…”

Section: Patients With Increased Numbers Of Ig-producing Bm Cells Of supporting

confidence: 73%

“…It is known that molecules of the various Ig classes differ in their rate of catabolism and in the distribu tion within body compartments [18]. When these differences are consid ered, the percentage distribution of Ig-containing BM cells corresponds to the relative Ig serum concentrations [4].…”

Section: Patients With Increased Numbers Of Ig-producing Bm Cells Of mentioning

confidence: 99%

“…Moreover, BM plasmocytosis may be modest [7]. In these situations, the determination of cytoplasmic Ig in plasma cells and large lymphoid cells in the BM [4,6] opens potentialities which have not yet been fully ex plored. It is the purpose of the present paper to fill this gap by a systemat ic analysis.…”

mentioning

confidence: 99%

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Cytoplasmic Immunoglobulins in Bone Marrow Cells of Polyclonal and of Monoclonal Origin

Morell¹,

Skvaril²,

Huser³

et al. 1978

Acta Haematol

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Cytoplasmic immunoglobulins in human bone marrow plasma cells and lymphoid cells were characterized by direct immunofluorescence with fluorochrome-labelled reagents specific for immunoglobulin heavy and light chains. The percentage distribution of cells containing IgA, IgG or IgM and χ- or λ-immunoglobulins was determined in bone marrow samples from 168 immunologically normal individuals, in 11 patients with polyclonal increase of bone marrow plasma cells and in 80 patients with benign or malignant monoclonal gammopathies. A clear differentiation between monoclonal and polyclonal cell populations could be obtained in all cases.

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Section: Patients With Increased Numbers Of Ig-producing Bm Cells Of supporting

confidence: 73%

Section: Patients With Increased Numbers Of Ig-producing Bm Cells Of mentioning

confidence: 99%

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Cytoplasmic Immunoglobulins in Bone Marrow Cells of Polyclonal and of Monoclonal Origin

Morell¹,

Skvaril²,

Huser³

et al. 1978

Acta Haematol

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“…Our normal values obtained by the examination of B and T cell mar kers from PB are about the same as or somewhat lower than those gener ally mentioned in the literature [3,4,9,15,16,20,22,27], Relatively fewer data are available about B and T cell markers from BM [1,5,14,17,19,20,23,25]. It has been firmly established that mature T lympho cytes do exist within the BM, too.…”

Section: Discussionmentioning

confidence: 63%

“…Investigations of B and T lymphocyte markers from the peripheral blood of patients with para proteinaemia revealed an increase in the number of lymphocytes bearing heavy or light chains of paraproteins [1,2,13,15,19,30]. Most proba bly, owing to the small quantity of aspirates the study of bone marrow B and T cell markers is less common.…”

Section: Abstract Studies Have Been Carried Out On B and T Cells In mentioning

confidence: 99%

B and T Cell Markers of Bone Marrow and Peripheral Blood Lymphoid Cells in Patients with Paraproteinaemia

et al. 1977

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Studies have been carried out on B and T cells in bone marrow and peripheral blood from patients with paraproteinaemia. The peripheral blood of patients with multiple myeloma showed a significant increase of B cells, mainly lymphoid cells bearing immunoglobulins corresponding to the paraproteins, while in patients with benign monoclonal gammopathy only a slight increase of B cells and a moderate decrease of T cells have been found. As to the bone marrow, the B cell population was significantly raised in patients with multiple myeloma, but it remained unchanged in patients with benign monoclonal gammopathy. Our findings may offer a new possibility to distinguish between these two diseases and provide further data to their pathogenesis.

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Coagulation Factor VIII

Pandolfi¹

1976

Arch Ophthalmol

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An Immunofluorescence Study on Intracellular Immunoglobulins in Human Bone Marrow Cells

Cited by 94 publications

References 8 publications

Cytoplasmic Immunoglobulins in Bone Marrow Cells of Polyclonal and of Monoclonal Origin

Cytoplasmic Immunoglobulins in Bone Marrow Cells of Polyclonal and of Monoclonal Origin

B and T Cell Markers of Bone Marrow and Peripheral Blood Lymphoid Cells in Patients with Paraproteinaemia

Coagulation Factor VIII

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