An Immune Thrombocytopenic Purpura-Like Picture Preceding Chronic Myelomonocytic Leukemia: A Case Series and Review of the Literature

Albayrak, Murat

doi:10.4999/uhod.14397

Cited by 2 publications

(2 citation statements)

References 11 publications

(23 reference statements)

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“…(1) as we had just published a series of six cases in the same topic (2). Additionally, a large study on autoimmunity in CMML, which was presented in American Society of Hematology 2012 congress (3), has been published as full paper very recently (4).…”

Section: To the Editormentioning

confidence: 99%

On the association between chronic myelomonocytic leukemia and immune thrombocytopenia: comments on the article by Hadjadj et al.

Büyükaşık

2015

European J of Haematology

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Section: To the Editormentioning

confidence: 99%

On the association between chronic myelomonocytic leukemia and immune thrombocytopenia: comments on the article by Hadjadj et al.

Büyükaşık

2015

European J of Haematology

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“…Notably, CMML was the main disease associated with peripheral destruction of platelets in our study population, as suggested previously [ 2 , 9 ]. Furthermore, we showed that a bone marrow smear is probably not useful for diagnosis of the mechanism of thrombocytopenia under these conditions [ 10 ]. This study had several limitations due to its retrospective nature and the small number of patients.…”

mentioning

confidence: 99%

Utility of indium-111 platelet scintigraphy for understanding the mechanism of thrombocytopenia associated with myelodysplastic syndromes and chronic myelomonocytic leukemia

Durand

Pottier²,

Mesguich

et al. 2023

Exp Hematol Oncol

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Background Thrombocytopenia occurs in 60% of patients with myelodysplastic syndromes (MDS), increasing the risk of life-threatening haemorrhage in this population of mainly old patients with comorbidities. However, data are scare regarding immune thrombocytopenia (ITP) secondary to MDS. Aim We analyzed the utility of indium-111 platelet scintigraphy (IPS) to better characterize the mechanisms of thrombocytopenia in 21 adult patients with MDS. Methods Adult patients with a definite diagnosis of MDS according to the international criteria who underwent IPS between 2009 and 2018 because of an increased bleeding risk were retrospectively selected. Autologous 111Indium platelet labelling was performed with a technique similar to that described previously using a standardized method. Results Platelet lifespan ≤ 6 days identified patients with peripheral platelet destruction. Taking into account the response to ITP-directed therapies after IPS, the sensitivity, specificity, and positive and negative predictive values of IPS were 100%, 84.6%, 80%, and 100%, respectively. Conclusion We show that IPS can be a useful tool to identify the mechanism and guide treatment of a chronic thrombocytopenia increasing the bleeding risk in patients with MDS.

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An Immune Thrombocytopenic Purpura-Like Picture Preceding Chronic Myelomonocytic Leukemia: A Case Series and Review of the Literature

Cited by 2 publications

References 11 publications

On the association between chronic myelomonocytic leukemia and immune thrombocytopenia: comments on the article by Hadjadj et al.

On the association between chronic myelomonocytic leukemia and immune thrombocytopenia: comments on the article by Hadjadj et al.

Utility of indium-111 platelet scintigraphy for understanding the mechanism of thrombocytopenia associated with myelodysplastic syndromes and chronic myelomonocytic leukemia

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