2004
DOI: 10.1111/j.1365-2249.2004.02446.x
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An imbalance of naive and memory/effector subsets and altered expression of CD38 on T lymphocytes in two girls with hyper-IgM syndrome

Abstract: SUMMARYIn this report we evaluated CD4 + T, CD8 + T and natural killer (NK) cell counts, the levels of naive/ memory subsets within the CD4 + T lymphocyte population, expression of CD38 on T lymphocytes, and CD4 + and CD8 + T cell cytokine production in two girls with hyper-IgM (HIM) syndrome. Both girls developed recurrent infections early in infancy, presenting a wide spectrum of clinical manifestations, with a strikingly different disease severity between them. CD4 + T cell counts were low in both children … Show more

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“…However, a specific defect T-cell cytokine production cannot be excluded by these studies. The low naïve CD4 cells identified in patient M1 mirrors those of the two female HIM patients reported by Costa-Carvalho et al [24] Whether the low naïve CD4 cells are a characteristic feature of other non X-linked HIM disorders requires further investigation.…”
Section: Discussionsupporting
confidence: 65%
“…However, a specific defect T-cell cytokine production cannot be excluded by these studies. The low naïve CD4 cells identified in patient M1 mirrors those of the two female HIM patients reported by Costa-Carvalho et al [24] Whether the low naïve CD4 cells are a characteristic feature of other non X-linked HIM disorders requires further investigation.…”
Section: Discussionsupporting
confidence: 65%